Acidosis clinical trials
The registry lists 111 studies for Acidosis across more than 10 countries. 19 are recruiting or about to start. 64 of them are mainly about Acidosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 4 narrower conditions too, such as Ketosis: 462 studies, 94 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
University of Colorado, Denver (5) · Albert Einstein College of Medicine (5) · Tricida, Inc. (4) · University Hospital, Montpellier (3) · Taipei Medical University Hospital (2) · ModernaTX, Inc. (2) · University of Edinburgh (2) · Mayo Clinic (2)
What is being tested here
Drugs under test in Acidosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- Jun 2027A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis · Phase 3 · Renibus Therapeutics, Inc.
- Nov 2026Bicarbonate HD Study · East and North Hertfordshire NHS Trust
- Dec 2026Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD · University of California, Davis
- Jan 2027Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis · Aydin Adnan Menderes University
- Aug 2027Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia · ModernaTX, Inc.
- Oct 2027Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit · Assiut University
Who these studies take
Of the 17 Acidosis studies recruiting now, 13 (76%) set no upper age limit and 2 (12%) stop at 75 or younger. 5 (29%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (12%) | 2 (12%) |
| 18 | 13 (76%) | 13 (76%) |
| 30 | 15 (88%) | 15 (88%) |
| 40 | 15 (88%) | 15 (88%) |
| 50 | 15 (88%) | 15 (88%) |
| 65 | 15 (88%) | 15 (88%) |
| 75 | 15 (88%) | 15 (88%) |
| 85 | 14 (82%) | 14 (82%) |
Across all 111 studies, recruiting or not: 33% stop at 75 or younger and 28% at 65; 23% take children; 8% are for women only and 3% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Acidosis studies take
Of 20 interventional studies with no phase under Acidosis, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo13–50 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 111. Browse all 111 → or search them.
- Fluid Administration in Ketoacidosis (DRINK)RecruitingNCT06541535Phase 41 country
- Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO ApplicationRecruitingNCT070999631 country
- A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic AcidosisRecruitingNCT07355062Phase 31 country
- Bicarbonate HD StudyRecruitingNCT077792001 country
- A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical PatientsRecruitingNCT07424625Phase 41 country
- Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney InjuryRecruitingNCT07464431Phase 41 country
- Frequency of Metabolic Acidosis in the Pediatric Intensive Care UnitNot yet recruitingNCT07803263
- Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic AcidosisNot yet recruitingNCT07688434Not applicable1 country
- Balanced Crystalloid vs Normal Saline in Pediatric Acute GastroenteritisRecruitingNCT076103821 country
- Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKDRecruitingNCT04984226Phase 21 country
- A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol PoisoningRecruitingNCT068816412 countries
- A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 StudyRecruitingNCT05130437Phase 1/28 countries
- Adding Urea to the Final Dialysis FluidRecruitingNCT06366230Phase 1/21 country
- Open-Label Study of mRNA-3927 in Participants With Propionic AcidemiaRecruitingNCT04159103Phase 1/28 countries
- Lactic Acidosis and Prior Metformin TreatmentRecruitingNCT073002931 country
- Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant RecipientsRecruitingNCT05005793Phase 41 country
- PLADO for Conservative Management of CKDRecruitingNCT06932042Not applicable1 country
- Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral NutritionRecruitingNCT06545565Phase 31 country
- ADVOS® Versus CVVHD in Metabolic or Mixed AcidosisRecruitingNCT05842369Not applicable1 country
- Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)CompletedNCT05113641Not applicable1 country
- Efficacy of Plant-protein Diets in Patients With Chronic Kidney DiseaseCompletedNCT05350098Not applicable1 country
- Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal AnesthesiaCompletedNCT06921473Phase 41 country
- the Effect of Interdialytic Serum Bicarbonate Correction on Vascular Calcification in Hemodialysis PatientsCompletedNCT07765459Phase 11 country
- Bone in CKD Alkali Response (BICARb Pilot Trial)TerminatedNCT05918029Phase 2/31 country
- Thiamine as Adjunctive Therapy for Diabetic KetoacidosisCompletedNCT03717896Phase 21 country
- Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICUCompletedNCT04010630Not applicable1 country
- Sodium Bicarbonate to Treat Severe Acidosis in the Critically IllCompletedNCT02476253Phase 31 country
- Treating Metabolic Acidosis in Chronic Kidney Disease to Prevent Adverse Kidney and Cardiovascular OutcomesCompletedNCT06545461Not applicable
- Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity HypoventilationTerminatedNCT04131660Not applicable1 country
- SODium BICarbonate for Metabolic Acidosis in the ICUActive, not recruitingNCT05697770Phase 37 countries
- A Phase 1 Study, to Evaluate the Effect of ADV7103 on Gastric pH Under Fed and Fasting Conditions in Adult Healthy Participants.CompletedNCT07446881Phase 11 country
- Clinical Prediction Models for Pediatric In-Hospital Death Risk in Congolese Severe Malaria Children Using Machine Learning Based-AlgorithmsCompletedNCT073554261 country
- Optimal Dosage of Acetazolamide for OSA TreatmentCompletedNCT04726982Phase 41 country
- Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.Active, not recruitingNCT06237712Not applicable1 country
- Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Following DaysCompletedNCT069084081 country
- Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKDCompletedNCT04600323Early Phase 11 country
- Effect of Flow Rate and PH on Muscle AcidosisTerminatedNCT05165277Not applicable1 country
- Osteoporosis, Trabecular Bone Score and Fracture Risk Assessment in Male Patients After Radical CystectomyCompletedNCT041532271 country
- Hyperlactatemia in Critically Ill Patients With Acute Kidney InjuryCompletedNCT065654031 country
- Intraoperative Cell Salvage and Postoperative AcidosisCompletedNCT028003431 country
- Diabetic Ketoacidosis Diagnosis and ManagementCompletedNCT063277371 country
- Open-glottis Pushing Technique Versus the Valsalva Pushing Technique in the Second Stage of LaborCompletedNCT06210087Not applicable1 country
- Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5CompletedNCT05970094Not applicable1 country
- The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy OperationsCompletedNCT059409351 country
- Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney DiseaseTerminatedNCT04727528Phase 32 countries
- Bicarbonate Administration in CKDCompletedNCT02915601Not applicable1 country
- The Threshold of Serum Anion Gap as a Screening Tool for Organic AcidosisCompletedNCT049759061 country
- The Effect of Bicarbonate Profiling in Dialysis Fluid on Phosphate Removal During Hemodialysis and Blood pHCompletedNCT05861700Not applicable1 country
- Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5Status unknownNCT05784389Not applicable1 country
- The Effects of Hypothermia and Acidosis on Coagulation During Treatment With Rivaroxaban Measured With ROTEMCompletedNCT056693131 country