Acidosis, Lactic clinical trials
The registry lists 48 studies for Acidosis, Lactic across more than 10 countries. 5 are recruiting or about to start. 19 of them are mainly about Acidosis, Lactic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Sangart (3) · University of Florida (3) · Tisento Therapeutics (2) · The Cleveland Clinic (1) · Columbia University (1) · Humanitas Hospital, Italy (1) · New York Institute of Technology (1) · University of British Columbia (1)
What is being tested here
Drugs under test in Acidosis, Lactic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tributyrin | 1 | 0 | 1 |
| Dichloroacetic Acid | 0 | 1 | 4 |
| Metformin | 0 | 0 | 3 |
| Zagociguat | 0 | 0 | 2 |
| Thiamine | 0 | 0 | 2 |
| OMT-28 | 0 | 0 | 1 |
| Nitroglycerin | 0 | 0 | 1 |
| Magnesium Sulfate | 0 | 1 | 1 |
| Albuterol | 0 | 0 | 1 |
| Fenoldopam | 0 | 0 | 1 |
Drug classes tested here Reverse transcriptase inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Dec 2026North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) · Columbia University
Who these studies take
Of the 3 Acidosis, Lactic studies recruiting now, 3 (100%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (33%) | 1 (33%) |
| 18 | 3 (100%) | 3 (100%) |
| 30 | 3 (100%) | 3 (100%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 3 (100%) | 3 (100%) |
| 75 | 3 (100%) | 3 (100%) |
| 85 | 3 (100%) | 3 (100%) |
Across all 48 studies, recruiting or not: 33% stop at 75 or younger and 29% at 65; 33% take children; 2% are for women only and 2% for men only; 17% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)TerminatedOct 30, 2026NCT06961344
Studies
Recruiting first, then most recently updated. Showing 48 of 48. search them.
- A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)Not yet recruitingNCT06792500Phase 1/21 country
- North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)RecruitingNCT016949402 countries
- Lactic Acidosis and Prior Metformin TreatmentRecruitingNCT073002931 country
- Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin PoisoningRecruitingNCT071930691 country
- EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIVEnrolling by invitationNCT0269973636 countries
- An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)TerminatedNCT06961344Phase 25 countries
- A Phase 2b Study of Zagociguat in Patients With MELASCompletedNCT06402123Phase 26 countries
- OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)CompletedNCT05972954Phase 23 countries
- Comparison of Peripheral Perfusion Indicators and Lactate LevelsCompletedNCT067273181 country
- Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac ArrestTerminatedNCT02974257Phase 21 country
- A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial DiseaseTerminatedNCT02473445Phase 21 country
- Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate DeclineCompletedNCT05984186Not applicable1 country
- The Threshold of Serum Anion Gap as a Screening Tool for Organic AcidosisCompletedNCT049759061 country
- Metformin in Diabetic Patients Undergoing Coronary AngiographyStatus unknownNCT04766008Phase 41 country
- Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse ReactionsStatus unknownNCT031268901 country
- Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart SurgeryCompletedNCT01524315Phase 41 country
- Study of Metformin OverdoseStatus unknownNCT047629661 country
- Remote Ischemic Preconditioning During Cardiopulmonary BypassWithdrawnNCT03723993Not applicable1 country
- Nitroglycerin Infusion During Cardiac SurgeryCompletedNCT01901419Not applicable1 country
- Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up StudyWithdrawnNCT02848508Phase 21 country
- Alcohol: Thiamine and or Magnesium 1CompletedNCT03466528Phase 2/31 country
- Thiamine Supplementation in Patients With Septic ShockWithdrawnNCT03122678Phase 11 country
- Metformin Treatment, Renal Function and Lactic AcidosisCompletedNCT013589941 country
- Lactic Acidosis During Entecavir(ETV)TreatmentTerminatedNCT01354652Phase 4
- Whole Body Periodic Acceleration on Blood Lactate and RecoveryCompletedNCT02482597Not applicable1 country
- Presep and Vascath Interaction StudyWithdrawnNCT007390891 country
- The Various Effects of Gaseous Albuterol on Serum LactateCompletedNCT02073747Not applicable1 country
- Metformin Use in Chronic Kidney Disease: The CKD-Met StudyStatus unknownNCT028441531 country
- Lactate Metabolism Study in HIV Infected PersonsCompletedNCT00202228Phase 41 country
- Pharmacotoxicology of Trichloroethylene MetabolitesCompletedNCT00874276Not applicable1 country
- Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic AcidemiaCompletedNCT00004493Phase 21 country
- Prevention of Dichloroacetate ToxicityCompletedNCT00031161Not applicable1 country
- Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic AcidosisCompletedNCT00004490Phase 3
- Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and FibrosisWithdrawnNCT00023218Not applicable1 country
- The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor ProgressionWithdrawnNCT006380401 country
- Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast MediaCompletedNCT01873859Not applicable1 country
- Phase 2c Dose Comparison Study of MP4OX in TraumaWithdrawnNCT01973504Phase 211 countries
- Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic AcidosisCompletedNCT009421231 country
- Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock PatientsCompletedNCT01262196Phase 214 countries
- Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock PatientsCompletedNCT01004198Phase 24 countries
- Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago HospitalCompletedNCT01580111Not applicable1 country
- Study of Blood Lactate Levels in Patients Treated With AntipsychoticsCompletedNCT011394631 country
- The Cytoadherence in Pediatric Malaria (CPM) StudyCompletedNCT007072001 country
- Fenoldopam and Splanchnic Perfusion During Cardiopulmonary BypassCompletedNCT00747331Phase 41 country
- D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)CompletedNCT00143702Phase 2/31 country
- Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic AcidemiaCompletedNCT000043531 country
- Dichloroacetate Kinetics, Metabolism and ToxicologyCompletedNCT000150151 country
- Evaluating the Effectiveness of a Dichloroacetate in MELAS SyndromeStatus unknownNCT00068913Phase 21 country