Leukemia, Promyelocytic, Acute clinical trials
The registry lists 134 studies for Leukemia, Promyelocytic, Acute across more than 10 countries. 16 are recruiting or about to start. 82 of them are mainly about Leukemia, Promyelocytic, Acute (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
National Cancer Institute (NCI) (19) · Gruppo Italiano Malattie EMatologiche dell'Adulto (8) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (7) · Memorial Sloan Kettering Cancer Center (6) · Children's Oncology Group (6) · M.D. Anderson Cancer Center (5) · Case Comprehensive Cancer Center (4) · Alliance for Clinical Trials in Oncology (3)
What is being tested here
Drugs under test in Leukemia, Promyelocytic, Acute studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · Antimetabolites 20 · Alkylating agents 9 · HDAC inhibitors 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- Mar 2027Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia · Phase 3 · Quetzal Therapeutics
- Jun 2027A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301) · Phase 3 · SDK Therapeutics, Inc.
- Dec 2026Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ... · National Cancer Institute (NCI)
- Jul 2027Venetoclax Combined With ATRA and ATO in Hyperleukocytic Acute Promyelocytic Leukemia · Anhui Medical University
- Sep 2027PET/MRI, 18F-FDG PET/CT and Whole Body MRI in Finding Extramedullary Myeloid Leukemia in Patients With Newly Diagnosed Acute Myeloid Leukemia · M.D. Anderson Cancer Center
Who these studies take
Of the 12 Leukemia, Promyelocytic, Acute studies recruiting now, 7 (58%) set no upper age limit and 5 (42%) stop at 75 or younger. 5 (42%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (42%) | 5 (42%) |
| 18 | 12 (100%) | 12 (100%) |
| 30 | 11 (92%) | 11 (92%) |
| 40 | 10 (83%) | 10 (83%) |
| 50 | 10 (83%) | 10 (83%) |
| 65 | 10 (83%) | 10 (83%) |
| 75 | 9 (75%) | 9 (75%) |
| 85 | 7 (58%) | 7 (58%) |
Across all 134 studies, recruiting or not: 34% stop at 75 or younger and 17% at 65; 47% take children; 1% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 134. Browse all 134 → or search them.
- Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic LeukemiaRecruitingNCT01409161Phase 21 country
- Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...RecruitingNCT02390752Phase 11 country
- Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic LeukemiaRecruitingNCT07504458Phase 35 countries
- PET/MRI, 18F-FDG PET/CT and Whole Body MRI in Finding Extramedullary Myeloid Leukemia in Patients With Newly Diagnosed Acute Myeloid LeukemiaRecruitingNCT02390635Phase 11 country
- Feasibility and Efficiency Study for the Implementation of a New Screening Method for Patients With Acute Myeloid Leukemia, in Laboratory PracticeNot yet recruitingNCT07867704Not applicable
- Lisaftoclax for Prevention of Differentiation Syndrom in Acute Promyelocytic Leukemia PatientsNot yet recruitingNCT07597941Phase 2/3
- A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301)Not yet recruitingNCT07296445Phase 3
- Frontline Oral Arsenic Trioxide for APLRecruitingNCT04687176Phase 22 countries
- Oral Arsenic With ATRA for Newly Diagnosed Patients With Acute Promyelocytic LeukemiaRecruitingNCT06982274Phase 21 country
- Venetoclax for Prevention of Differentiation Syndrom in Acute Promyelocytic Leukemia PatientsEnrolling by invitationNCT06544109Phase 2/31 country
- Optimum Induction Therapy of Low-risk APLRecruitingNCT05832320Not applicable1 country
- Treatment Study for Children and Adolescents With Acute Promyelocytic LeukemiaRecruitingNCT04793919Phase 212 countries
- National Acute Promyelocytic Leukemia (APL) Observational Study NAPOLEON-Registry of the German AML IntergroupRecruitingNCT021926191 country
- RWE of 1st Line Treatment With ATO/ATRA for Adult APLRecruitingNCT048974901 country
- Effectiveness and Safety of Therapy Based on Attenuated ATO Plus Low-Dose ATRA in Patients With APLRecruitingNCT05497310Phase 1/21 country
- The Acute Promyelocytic Leukaemia Asian Consortium (APL-AC) ProjectRecruitingNCT042517541 country
- French Registry of First-line Treatment of Acute Promyelocytic LeukemiaCompletedNCT029388581 country
- Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic LeukemiaActive, not recruitingNCT03253848Not applicable2 countries
- Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic LeukemiaCompletedNCT02688140Phase 35 countries
- Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic LeukemiaActive, not recruitingNCT02339740Phase 36 countries
- Evaluate the Pharmacokinetics of Oral Arsenic Trioxide Solution Under Fasting and Fed Conditions, to Compare Intravenous Arsenic Trioxide, in Acute Promyelocytic LeukemiaCompletedNCT06882031Phase 11 country
- AI-Assisted Acute Myeloid Leukemia Evaluation With the Leukemia End-to-End Analysis Platform (LEAP) Versus Clinician-Only AssessmentCompletedNCT07203885Not applicable1 country
- Venetoclax Combined With ATRA and ATO in Hyperleukocytic Acute Promyelocytic LeukemiaActive, not recruitingNCT07187505Not applicable1 country
- Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell TransplantCompletedNCT01588015Phase 11 country
- A Study for Oral SY-2101 for Participants With Acute Promyelocytic LeukemiaSuspendedNCT04996030Phase 11 country
- Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic LeukemiaActive, not recruitingNCT000038611 country
- Comparison of Three Treatment Regimens in Treating Patients With Relapsed or Refractory Acute Myelogenous LeukemiaCompletedNCT00005962Phase 23 countries
- S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic LeukemiaCompletedNCT00492856Phase 31 country
- S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic LeukemiaCompletedNCT00551460Phase 21 country
- Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic LeukemiaCompletedNCT00866918Phase 33 countries
- Study on Number and Outcome of Pregnancy in Acute Promielocitic Leukaemia (APL) Patients Treated With ChemotherapyCompletedNCT014721071 country
- Phase III Trial in Acute Promyelocytic Leukemia PatientsCompletedNCT00482833Phase 33 countries
- Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic LeukaemiaStatus unknownNCT03624270Phase 21 country
- Quizartinib and High-dose Ara-C Plus Mitoxantrone in Relapsed/Refractory AML With FLT3-ITDTerminatedNCT03989713Phase 21 country
- Sorafenib Tosylate and Chemotherapy in Treating Older Patients With Acute Myeloid LeukemiaCompletedNCT01253070Phase 21 country
- Study of Biomarkers in DNA Samples From Patients With Acute Lymphoblastic Leukemia or Acute Myeloid LeukemiaCompletedNCT010052771 country
- A Study for Improving the Outcome of Childhood Acute Promyeloid LeukemiaCompletedNCT02200978Phase 41 country
- Long-term Safety Study of Arsenic Trioxide in Newly Diagnosed, Low-to-intermediate Risk Acute Promyelocytic LeukemiaStatus unknownNCT037519171 country
- Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission TherapyCompletedNCT01404949Phase 22 countries
- Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)Status unknownNCT02899169Phase 31 country
- Long-term QoL in Acute Promyelocytic Leukemia Treated With ATO or Standard ChemotherapyStatus unknownNCT030964961 country
- "AIDA" Protocol (LAP 0493)Status unknownNCT01064557Not applicable5 countries
- AIDA 2000 GuidelinesStatus unknownNCT01064570Phase 21 country
- Results From a Mexican Acute Promyelocytic Leukemia.CompletedNCT045628181 country
- Erlotinib Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid LeukemiaCompletedNCT01664897Phase 21 country
- Randomized,International Multi-center Clinical Trial of RIF Plus RA for Non-high-risk APLStatus unknownNCT04175587Phase 3
- R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous LeukemiaCompletedNCT00004009Phase 11 country
- Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic CancerCompletedNCT00105001Phase 23 countries
- Bone Marrow Transplantation in Treating Patients With Hematologic CancerCompletedNCT00003398Phase 41 country
- Peripheral Stem Cell Transplantation in Treating Patients With Hematologic CancerCompletedNCT00003396Phase 21 country