Liver Cirrhosis, Biliary clinical trials
The registry lists 214 studies for Liver Cirrhosis, Biliary across more than 10 countries. 48 are recruiting or about to start. 180 of them are mainly about Liver Cirrhosis, Biliary (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Status
Who runs them
Xijing Hospital of Digestive Diseases (12) · Intercept Pharmaceuticals (11) · Gilead Sciences (10) · GlaxoSmithKline (8) · Ipsen (8) · University of Alberta (7) · Mayo Clinic (7) · University of Aarhus (6)
What is being tested here
Drugs under test in Liver Cirrhosis, Biliary studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fenofibrate | 7 | 9 | 13 |
| Saroglitazar | 3 | 4 | 6 |
| Ursodeoxycholic Acid | 3 | 3 | 6 |
| Seladelpar | 2 | 5 | 9 |
| Linerixibat | 1 | 3 | 7 |
| Elifibranor | 1 | 4 | 5 |
| Linafexor | 1 | 1 | 5 |
| Nemolizumab | 1 | 0 | 1 |
| Upadacitinib | 1 | 0 | 1 |
| Nalmefene | 1 | 0 | 1 |
Drug classes tested here Corticosteroids 5 · Reverse transcriptase inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Study of Elafibranor in Adult Japanese Participants With Primary Biliary Cholangitis (PBC) · Phase 3 · Ipsen
- Apr 2027Fenofibrate in Patients With Primary Biliary Cholangitis (PBC) · Phase 3 · Xijing Hospital of Digestive Diseases
- Apr 2027Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis · Phase 3 · Zydus Therapeutics Inc.
- Dec 2026Patients With Primary Biliary Cholangitis · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Dec 2026Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver Disease · Zydus Therapeutics Inc.
- Jan 2027A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis · Mirum Pharmaceuticals, Inc.
- Mar 2027TH104 for the Treatment of Pruritus in Primary Biliary Cholangitis · Tharimmune Inc
- May 2027Patients With Primary Biliary Cholangitis(PBC) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Jul 2027Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease Progression · Beijing Municipal Administration of Hospitals
- Jul 2027Biochemical Response and Clinical Outcomes in Patients With PBC · RenJi Hospital
Who these studies take
Of the 34 Liver Cirrhosis, Biliary studies recruiting now, 16 (47%) set no upper age limit and 11 (32%) stop at 75 or younger. 3 (9%) take children under 18. 1 (3%) are for women only and 0 (0%) for men only; 4 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (9%) | 2 (6%) |
| 18 | 33 (97%) | 32 (94%) |
| 30 | 34 (100%) | 33 (97%) |
| 40 | 34 (100%) | 33 (97%) |
| 50 | 34 (100%) | 33 (97%) |
| 65 | 34 (100%) | 33 (97%) |
| 75 | 31 (91%) | 30 (88%) |
| 85 | 19 (56%) | 18 (53%) |
Across all 214 studies, recruiting or not: 45% stop at 75 or younger and 9% at 65; 6% take children; 2% are for women only and 1% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Liver Cirrhosis, Biliary studies take
Of 21 phase 2 interventional studies under Liver Cirrhosis, Biliary, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 6 mo2–24 · 15 studies | — | — |
| Phase 2 | 23 mo18–34 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting2
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 214. Browse all 214 → or search them.
- A Study of CS0159 in Patients With PBC With Inadequate Response or Intolerance to UDCARecruitingNCT07282353Phase 31 country
- Linerixibat Compassionate Use for Cholestatic Pruritus Adult Patients With Primary Biliary Cholangitis (PBC)AvailableNCT05448170
- Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated CirrhosisRecruitingNCT06051617Phase 329 countries
- FIREFLY Trial: Fenofibrate Intervention---Randomized Evaluation in First-Line PBC TherapyRecruitingNCT07296458Phase 31 country
- A Study of Fatigue, Itching and Daily Activities in People With Primary Biliary Cholangitis Starting ElafibranorNot yet recruitingNCT07906639
- Fenofibrate in Patients With Primary Biliary Cholangitis (PBC)RecruitingNCT06365424Phase 2/31 country
- Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic AcidRecruitingNCT02823366Phase 31 country
- A Multicenter, Randomized, Controlled Trial of Prednisone Combined With Ursodeoxycholic Acid in the Treatment of Primary Biliary Cholangitis With Moderate to Severe Interface Hepatitis CharacteristicsEnrolling by invitationNCT06591468Phase 2/31 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- Study of Seladelpar and Cilofexor in Participants With Primary Biliary CholangitisRecruitingNCT07841977Phase 21 country
- Elafibranor Pregnancy Surveillance Program: A Study to Evaluate the Safety of Elafibranor During PregnancyRecruitingNCT075569131 country
- A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary CholangitisRecruitingNCT06016842Phase 328 countries
- J-LINX: Japan LINerixibat eXtension StudyNot yet recruitingNCT07860710Phase 3
- Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic PruritusNot yet recruitingNCT07843420Phase 21 country
- Study of Saroglitazar Magnesium for PBC Patients With Incomplete Response or Intolerant to UDCA TherapyRecruitingNCT07424677Phase 31 country
- Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver DiseaseRecruitingNCT06825559Phase 11 country
- Phase I/II Trial of Human Umbilical Cord Mesenchymal Stromal Cells for UDCA-Refractory Primary Biliary CholangitisNot yet recruitingNCT07795151Phase 1/21 country
- Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease ProgressionNot yet recruitingNCT077338821 country
- Long-Term Study to Evaluate the Safety and Efficacy in Participants With Primary Biliary Cholangitis of Saroglitazar Magnesium-V on Clinical OutcomesRecruitingNCT07216235Phase 31 country
- LEOPARD Prospective Validation Cohort 1RecruitingNCT067232755 countries
- LEOPARD Training and Validation Data Collection StudyRecruitingNCT066756047 countries
- The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe ItchingNot yet recruitingNCT07678645Phase 21 country
- Using Digital Health Technology to Monitor Patients With Primary Biliary Cholangitis (PBC)Enrolling by invitationNCT076314421 country
- Austrian PBC RegistryRecruitingNCT075986691 country
- The Value of Spleen Stiffness Measurement in Patients With PBCNot yet recruitingNCT07319169Not applicable1 country
- Liver-gut Axis Study Through Identification of Liver Disease-specific MicrobiomeRecruitingNCT065191621 country
- Biochemical Response and Clinical Outcomes in Patients With PBCRecruitingNCT074497931 country
- Biobank for Cholestatic Liver Diseases.RecruitingNCT034455851 country
- Fenofibrate Combined With Ursodeoxycholic Acid in Subjects With Primary Biliary CholangitisRecruitingNCT05751967Phase 31 country
- Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis: a Real World StudyRecruitingNCT06755541Phase 31 country
- Fenofibrate for Compensated Cirrhosis Patients With Primary Biliary CholangitisRecruitingNCT05749822Phase 2/31 country
- Fenofibrate in Primary Biliary Cholangitis: a Real World StudyRecruitingNCT06755151Phase 31 country
- Early Diagnosis of Primary Biliary Cholangitis (PBC) in Patients With Positive Anti-Mitochondrial Antibodies (AMA) and Normal Alkaline Phosphatase (ALP)RecruitingNCT072058741 country
- TH104 for the Treatment of Pruritus in Primary Biliary CholangitisNot yet recruitingNCT06733519Phase 2
- RELIEF: Multimodal Prehabilitation to Treat Fatigue in Patients With Primary Biliary CholangitisRecruitingNCT07161245Not applicable1 country
- PBC Long-term Outcomes StudyRecruitingNCT071496751 country
- Swiss Primary Biliary Cholangitis Cohort StudyRecruitingNCT031469101 country
- Monitoring the Response of Combination Ursodiol and Seladelpar TreatmentNot yet recruitingNCT07122206
- National Database on Primary Biliary CholangitisRecruitingNCT051518091 country
- Clinical Research of Tapering UDCA in PBC Patients With a Complete ResponseRecruitingNCT04650243Phase 41 country
- Spanish Registry of Autoimmune and Cholestatic Liver Diseases (ColHai)RecruitingNCT067676051 country
- Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune DiseasesNot yet recruitingNCT06417398Early Phase 1
- Clinical Study on the Treatment of Elevated Total Bilirubin in Primary Biliary Cholangitis With Baobao Dan CapsuleNot yet recruitingNCT06371196Phase 4
- Detection Program for Patients With Primary Biliary Cholangitis Lost in the SystemRecruitingNCT059194331 country
- Prospective, Multicenter Cohort Study on Primary Biliary CholangitisRecruitingNCT040765271 country
- Bezafibrate in Patients With Primary Biliary Cholangitis (PBC)RecruitingNCT045149651 country
- sCD163 in PBC Patients - Assessment of Treatment ResponseRecruitingNCT029315131 country
- An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic SteatosisRecruitingNCT053356031 country
- Efficacy of Different Doses of Bezafibrate in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary CholangitisCompletedNCT07926087Phase 41 country
- Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)Active, not recruitingNCT04526665Phase 314 countries