Cholangitis, Sclerosing clinical trials
The registry lists 149 studies for Cholangitis, Sclerosing across more than 10 countries. 39 are recruiting or about to start. 110 of them are mainly about Cholangitis, Sclerosing (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29.
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Status
Who runs them
Mayo Clinic (13) · Gilead Sciences (7) · Assistance Publique - Hôpitaux de Paris (6) · Brigham and Women's Hospital (5) · Stanford University (4) · Perspectum (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · University of Birmingham (3)
What is being tested here
Drugs under test in Cholangitis, Sclerosing studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Sep 2027Study with Norucholic Acid Tablets in Patients with Primary Sclerosing Cholangitis (PSC) · Phase 3 · Dr. Falk Pharma GmbH
- Jan 2027A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions · Imperial College London
- Mar 2027Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC · University of Minnesota
- Apr 2027Biodegradable Stents in Primary Sclerosing Cholangitis · King's College Hospital NHS Trust
- May 2027Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis. · Aparna Goel
- May 2027Detoxification of the Liver In PSC (Dolphin) · Brigham and Women's Hospital
- May 2027Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study · Stanford University
- Sep 2027FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis · University of Birmingham
- Nov 2027The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching · RenJi Hospital
Who these studies take
Of the 30 Cholangitis, Sclerosing studies recruiting now, 12 (40%) set no upper age limit and 13 (43%) stop at 75 or younger. 9 (30%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 9 (30%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (20%) | 6 (20%) |
| 18 | 29 (97%) | 29 (97%) |
| 30 | 27 (90%) | 27 (90%) |
| 40 | 27 (90%) | 27 (90%) |
| 50 | 26 (87%) | 26 (87%) |
| 65 | 26 (87%) | 26 (87%) |
| 75 | 22 (73%) | 22 (73%) |
| 85 | 15 (50%) | 15 (50%) |
Across all 149 studies, recruiting or not: 45% stop at 75 or younger and 13% at 65; 20% take children; 0% are for women only and 1% for men only; 17% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cholangitis, Sclerosing studies take
Of 23 phase 2 interventional studies under Cholangitis, Sclerosing, half reached primary completion within 37 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 37 mo21–62 · 23 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- FEAST and HOPE: Redox PSC Pilot StudyOct 27, 2026NCT07898839
Studies
Recruiting first, then most recently updated. Showing 50 of 149. Browse all 149 → or search them.
- Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research ApproachRecruitingNCT046852001 country
- FEAST and HOPE: Redox PSC Pilot StudyNot yet recruitingNCT07898839Phase 2
- A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing CholangitisRecruitingNCT07387549Phase 325 countries
- Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing CholangitisRecruitingNCT07341282Phase 21 country
- Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic PruritusNot yet recruitingNCT07843420Phase 21 country
- FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitisRecruitingNCT06286709Phase 21 country
- Vancomycin Efficacy in Response to Dysbiosis in Atypical ColitisNot yet recruitingNCT07646223Phase 21 country
- MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver DiseaseRecruitingNCT031786301 country
- A-LiNK: Improving Outcomes in Autoimmune Liver DiseaseRecruitingNCT057504981 country
- MRI Based Biomarkers in Pediatric Autoimmune Liver DiseaseRecruitingNCT031754711 country
- LEOPARD Prospective Validation Cohort 1RecruitingNCT067232755 countries
- LEOPARD Training and Validation Data Collection StudyRecruitingNCT066756047 countries
- Detoxification of the Liver In PSC (Dolphin)RecruitingNCT05835505Phase 21 country
- Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver TransplantationRecruitingNCT06905054Phase 21 country
- Primary Sclerosing Cholangitis in ChildrenRecruitingNCT041811382 countries
- The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe ItchingNot yet recruitingNCT07678645Phase 21 country
- Biodegradable Stents in Primary Sclerosing CholangitisRecruitingNCT07607353Not applicable1 country
- Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSCRecruitingNCT06197308Early Phase 11 country
- Liver-gut Axis Study Through Identification of Liver Disease-specific MicrobiomeRecruitingNCT065191621 country
- Fecal Microbiota Transplantation for Primary Sclerosing Cholangitis - Randomized Study Versus Sham TransplantationNot yet recruitingNCT07477782Phase 21 country
- A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)RecruitingNCT07229911Phase 11 country
- Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics StudyRecruitingNCT05912387Early Phase 11 country
- Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC PatientsRecruitingNCT047539961 country
- Biobank for Cholestatic Liver Diseases.RecruitingNCT034455851 country
- A Study of SIPLIZUMAB in AILD and LT PatientsRecruitingNCT06455280Phase 11 country
- A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSCRecruitingNCT06699121Phase 21 country
- Swiss Primary Sclerosing Cholangitis Cohort StudyRecruitingNCT031469361 country
- Vancomycin in Primary Sclerosing Cholangitis in ItalyRecruitingNCT05876182Phase 21 country
- Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis.RecruitingNCT05295680Phase 21 country
- Efficacy and Safety of HK-660S in the Treatment of Primary Sclerosing CholangitisNot yet recruitingNCT06975150Phase 2
- Study with Norucholic Acid Tablets in Patients with Primary Sclerosing Cholangitis (PSC)Not yet recruitingNCT06886360Phase 3
- A Simple Breath Test to Detect Liver Cancer and Monitor Liver ConditionsRecruitingNCT068641951 country
- Spanish Registry of Autoimmune and Cholestatic Liver Diseases (ColHai)RecruitingNCT067676051 country
- Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde CholangiopancreatographyNot yet recruitingNCT06670547
- Registry for Advanced EndoscopyRecruitingNCT051873121 country
- National Database on Primary Sclerosing Cholangitis (PSC)RecruitingNCT056181451 country
- Clinical Application of Annual Liver Multiscan and MRCP+ in Primary Sclerosing CholangitisNot yet recruitingNCT05462093Not applicable
- An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic SteatosisRecruitingNCT053356031 country
- Treating Primary Sclerosing Cholangitis and Biliary Atresia With VancomycinRecruitingNCT02137668Phase 11 country
- The Effects of Bromelain Supplement in Patients With Ulcerative ColitisCompletedNCT06351696Phase 2/31 country
- A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.Active, not recruitingNCT05627362Phase 27 countries
- Vancomycin for Primary Sclerosing CholangitisTerminatedNCT03710122Phase 2/31 country
- A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)Active, not recruitingNCT04663308Phase 214 countries
- Gluten-free Diet in PSC and IBDCompletedNCT06026449Not applicable1 country
- Secondary Sclerosing Cholangitis in Critically Ill PatientsActive, not recruitingNCT025453091 country
- Evaluation of Maralixibat in Pruritus Associated With General Cholestatic Liver Disease (EXPAND)Active, not recruitingNCT06553768Phase 310 countries
- Deciphering the Self-antigen Specific T Cell Signature of Autoimmune Liver DiseasesCompletedNCT077848811 country
- S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC)CompletedNCT06026865Not applicable1 country
- A POC and Dose-Ranging Study of HTD1801 in PSC PatientsCompletedNCT03333928Phase 22 countries
- A Study of HTD1801 in Adolescents With Primary Sclerosing Cholangitis (PSC)WithdrawnNCT03678480Phase 2