Raynaud Disease clinical trials
The registry lists 81 studies for Raynaud Disease across more than 10 countries. 8 are recruiting or about to start. 59 of them are mainly about Raynaud Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-09.
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· Enrollment: 300 → 450 participants
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Who runs them
MediQuest Therapeutics (8) · University Hospital, Grenoble (6) · London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's (3) · Emory University (2) · Johns Hopkins University (2) · Brigham and Women's Hospital (2) · Seoul National University Hospital (2) · Sanjay Gandhi Postgraduate Institute of Medical Sciences (2)
What is being tested here
Drugs under test in Raynaud Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Treprostinil | 2 | 0 | 3 |
| Botulinum toxin type A | 1 | 3 | 6 |
| Oxygen | 1 | 0 | 1 |
| Nitroglycerin | 0 | 1 | 4 |
| Onabotulinum toxin A | 0 | 1 | 3 |
| Tadalafil | 0 | 1 | 3 |
| Nifedipine | 0 | 1 | 2 |
| Sildenafil | 0 | 2 | 2 |
| Cilostazol | 0 | 0 | 2 |
| Botulinum Toxins | 0 | 0 | 1 |
Drug classes tested here PDE5 inhibitors 6
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Feb 2027A Study of LIQ861 (Inhaled Treprostinil) in Adults With Systemic Sclerosis Who Have Symptomatic Raynaud's Phenomenon Attacks · Liquidia Technologies, Inc.
Who these studies take
Of the 5 Raynaud Disease studies recruiting now, 4 (80%) set no upper age limit and 1 (20%) stop at 75 or younger. 1 (20%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 4 (80%) | 4 (80%) |
Across all 81 studies, recruiting or not: 42% stop at 75 or younger and 17% at 65; 10% take children; 2% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 81. Browse all 81 → or search them.
- Emerging Indications for Hyperbaric Oxygen TreatmentNot yet recruitingNCT07240649Phase 4
- A Study of LIQ861 (Inhaled Treprostinil) in Adults With Systemic Sclerosis Who Have Symptomatic Raynaud's Phenomenon AttacksNot yet recruitingNCT07748000Phase 2
- Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's DiseaseNot yet recruitingNCT05698979Phase 31 country
- Open Label Treprostinil Raynaud's StudyRecruitingNCT07112183Phase 41 country
- The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of LifeRecruitingNCT06675344Not applicable1 country
- Multi-modal Quantitative Imaging of the SkinRecruitingNCT069892161 country
- Application for Monitoring and Evaluation of Raynaud's PhenomenonRecruitingNCT039844221 country
- Follow-up of SPTS in Patients With Raynaud's PhenomenonRecruitingNCT040151931 country
- Botulinum Toxin in Raynaud's PhenomenonCompletedNCT05125029Phase 41 country
- Effects of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic SclerosisCompletedNCT02260557Phase 23 countries
- Metabolomic Analysis of Systemic SclerosisTerminatedNCT022987771 country
- Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.TerminatedNCT03869008Not applicable1 country
- Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 2)CompletedNCT03867097Phase 21 country
- Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)CompletedNCT04040322Phase 31 country
- Early Diagnosis of SSc in the General Rheumatology Clinic - PilotCompletedNCT062911421 country
- Apollo Device for Fatigue in Systemic SclerosisCompletedNCT04854850Not applicable1 country
- Treatment of Frostbite Sequelae With Botulinum Toxin AWithdrawnNCT06460194Phase 21 country
- Exparel as a Nerve Block for Severe Hand PainTerminatedNCT02374320Phase 2/31 country
- A Study to Assess the Effect of Oral Temanogrel on Digital Blood Flow in Adult Participants With Raynaud's Phenomenon Secondary to Systemic SclerosisTerminatedNCT04915950Phase 22 countries
- Safety, Tolerability, and Pharmacodynamic Profile of Oral 2101 in Secondary Raynaud's DiseaseCompletedNCT00528242Phase 21 country
- Cold Challenge With C21 in RPCompletedNCT04388176Phase 21 country
- Phototherapy For Treatment Of Raynaud's PhenomenonWithdrawnNCT04898036Not applicable1 country
- Functional Exercise Tests in Patients With Systemic SclerosisStatus unknownNCT046506591 country
- Rheopheresis for Raynaud's and Digital Ulcers in Systemic SclerosisStatus unknownNCT05204784Not applicable1 country
- Efficacy of Botulinum Toxin A in Adult Subjects With Raynaud Phenomenon Secondary to Systemic SclerosisCompletedNCT03717961Phase 31 country
- Assess Efficacy of of Oral Treprostinil in Patients With Symptomatic Primary or Secondary Raynaud's PhenomenonCompletedNCT02583789Early Phase 11 country
- Cocoa Flavanol Supplementation in Raynaud's PhenomenonCompletedNCT03815162Not applicable1 country
- Dermoscopy in Primary Raynaud's PhenomenonCompletedNCT046445231 country
- The Effect of Abobotulinum Toxin A on the Symptoms of Raynaud's PhenomenonTerminatedNCT03639766Phase 41 country
- Nutritional Strategies to Increase Nitric Oxide Signaling in Raynaud's PhenomenonStatus unknownNCT03749577Not applicable1 country
- Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort StudyTerminatedNCT026421461 country
- Effectiveness of Electric Stimulation Therapy in Raynaud's PhenomenonCompletedNCT03699436Not applicable1 country
- Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's PhenomenonCompletedNCT02202291Not applicable1 country
- Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.CompletedNCT03211325Not applicable1 country
- Beet the Cold: The Effect of Inorganic Nitrate Supplementation in Individuals With Raynaud's PhenomenonCompletedNCT03129178Not applicable1 country
- Localized Effects of PBM and Exogenous NO on CREST Patients Calcinosis Cutis & Raynaud PhenomenonStatus unknownNCT039725661 country
- The Effects of Exercise in Patients With Systemic SclerosisCompletedNCT03058887Not applicable1 country
- Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's PhenomenonCompletedNCT03094910Not applicable1 country
- A Two-Part Study of BOTOX® Therapy for Ischemic DigitsCompletedNCT01309802Phase 21 country
- Tadalafil-Delivra and Raynaud's PhenomenonWithdrawnNCT033933251 country
- A Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)CompletedNCT02506062Not applicable1 country
- Scleroderma Treatment With Celution Processed Adipose Derived Regenerative Cells (STAR)CompletedNCT02396238Not applicable1 country
- PF-00489791 For The Treatment Of Raynaud'sCompletedNCT01090492Phase 211 countries
- Diosmiplex (Vasculera®) in Primary and Secondary Raynaud's PhenomenonCompletedNCT02683408Not applicable1 country
- Efficacy and Tolerability of Ginkgo Biloba Extract in Patients With Raynaud´s PhenomenonCompletedNCT00251238Phase 21 country
- Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary RaynaudCompletedNCT03027674Early Phase 11 country
- Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's SyndromeCompletedNCT02165111Phase 31 country
- Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic SclerosisCompletedNCT01347008Phase 31 country
- Laser Speckle Contrast Imaging for Cutaneous Microvascular Dysfunction Detection in Systemic Sclerosis.CompletedNCT01743612Not applicable1 country
- CSL Behring Sclero XIIIStatus unknownNCT02551042Phase 21 country