A Phase 2 interventional study of Adempas in Chronic Thromboembolic Disease (CTED) and Exercise Intolerance Post PEA Surgery, sponsored by University of Colorado, Denver. Completed at 1 site in United States. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-02-05.
Sponsored by University of Colorado, Denver · Phase 2, Interventional, and Treatment
This is an open label study of Riociguat in patients with continued exercise intolerance at least 6 months following pulmonary endarterectomy (PEA).
Exclusion Criteria:
Riociguat (Adempas) 0.5mg to 2.5 mg three time daily - oral medication
Drug: Adempas
After obtaining baseline data, patients will be placed on oral riociguat at a dose of 0.5 mg TID which will be up titrated over two months to a maximum dose of 2.5 mg TID or maximum tolerated dose. After 3 months from onset of riociguat initiation, the University of California San Diego (UCSD) shortness of breath score, 6 Minute Walk Test (6MWD), and resting/exercise Right Heart Catheterization (RHC) will be repeated.
Also known as: Riociguat
Change in mean pulmonary arterial pressure
Measurements include mPAP (mean pulmonary arterial pressure) measured by right heart catheterization (RHC)
Time frame: Baseline and 3 months
Change in cardiac output
Measurements include CO (cardiac output) mPAP/CO slope measured by right heart catheterization (RHC)
Time frame: Baseline and 3 months
Change in Pulmonary artery compliance
Measurements include Pulmonary artery compliance measured by right heart catheterization (RHC)
Time frame: Baseline and 3 months
Change in 6 minute walk test
Measurements include change in 6 minute walk test (6 MWT) following 3 months of study drug
Time frame: Baseline and 3 months
Change in New York Heart Association (NYHA) functional class
Measurements include Change in New York Heart Association (NYHA) functional class following 3 months of study drug
Time frame: Baseline and 3 months
Change in the University of California San Diego (UCSD) shortness of Breath Score
Measurements include: Change in the University of California San Diego (UCSD) shortness of Breath Score following 3 months of study drug
Time frame: Baseline and 3 months
Plan to share: No
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This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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University of Colorado, Denver