Riluzole clinical trials
Also written Rilutek and BHV-0223.
How each study uses Riluzole is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 12 Dec 1995 · RILUTEK · NDA 020599 (FDA, Drugs@FDA)
- European Union
- 10 Jun 1996 · Rilutek · EMEA/H/C/000109 (EMA)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
50 studies that test it; most in 2009 (6)
| Year | Studies |
|---|---|
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 1 |
| 2003 | 1 |
| 2004 | 1 |
| 2005 | 2 |
| 2006 | 3 |
| 2007 | 2 |
| 2008 | 1 |
| 2009 | 6 |
| 2010 | 1 |
| 2011 | 2 |
| 2012 | 1 |
| 2013 | 6 |
| 2014 | 2 |
| 2016 | 1 |
| 2017 | 2 |
| 2018 | 2 |
| 2019 | 1 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 2 |
| 2024 | 1 |
| 2025 | 3 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 6 · Other 44
Yale University (5) · National Institute of Mental Health (NIMH) (4) · S. Andrea Hospital (3) · Rutgers, The State University of New Jersey (2) · Assistance Publique - Hôpitaux de Paris (2) · Mclean Hospital (2) · AOSpine North America Research Network (2) · Johns Hopkins University (2)
Often tested with
Tested in the same studies.
Pregabalin (2) · Sorafenib (1) · Bevacizumab (1) · Amiloride (1) · Fluoxetine (1) · D-serine zwitterion (1) · Isradipine (1) · Memantine (1)
Related medicines
As reviewed, each with the page that says it.
- One of Neuroprotective Agents source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 1
Studies that test Riluzole.
- Jul 2027Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot TrialPhase 2 · University of California, Irvine
Studies
Open first, then newest update. How each study uses Riluzole is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 50
- Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot TrialRecruitingPhase 2University of California, IrvineNCT06580002Written as Riluzole
- Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in U.S. Healthy ParticipantsNot yet recruitingPhase 1Neurodawn Pharmaceutical Co., Ltd.NCT07618715Written as Riluzole tablet
- Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot TrialRecruitingPhase 2University of California, IrvineNCT07447050Written as Riluzole
- Safety of Intrathecal Riluzole in Patients With Amyotrophic Lateral SclerosisNot yet recruitingPhase 1Brain Trust BioNCT07093268Written as Intrathecal Riluzole
- Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in Chinese Healthy SubjectRecruitingPhase 1Beijing Tiantan HospitalNCT06935721Written as Riluzole tablet
- Riluzole in Patients With Spinocerebellar Ataxia Type 7RecruitingPhase 2/3S. Andrea HospitalNCT03660917Written as Riluzole
- The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant SchizophreniaRecruitingEarly Phase 1King's College LondonNCT06270108Written as Riluzole
- RiLuzole to Reduce Atrial FIb Study Using Holter MonitoringRecruitingPhase 2University of UtahNCT05292209Written as Riluzole 50 MG
- Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or MelanomaActive, not recruitingPhase 1National Cancer Institute (NCI)NCT01303341Written as Riluzole
- Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.SuspendedPhase 2UNICANCERNCT03722680Written as Riluzole
- A Pilot Study of Riluzole Versus Placebo in the Treatment of Children and Adolescents With ASDCompletedPhase 2Holland Bloorview Kids Rehabilitation HospitalNCT01661855Written as Riluzole
- Riluzole Orodispersible Film Replicate BioavailabilityCompletedPhase 1Cross Research S.A.NCT04819438Written as Riluzole 50 mg orodispersible film
- Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal CancerCompletedPhase 1Ning JinNCT04761614Written as Riluzole
- Effect of Riluzole as a Symptomatic Approach in Patients With Chronic Cerebellar AtaxiaCompletedPhase 2S. Andrea HospitalNCT00202397Written as Riluzole
- Riluzole in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by SurgeryCompletedPhase 2Rutgers, The State University of New JerseyNCT00866840Written as riluzole
- Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury ConditionStatus unknownPhase 2Assistance Publique Hopitaux De MarseilleNCT02859792Written as Riluzole
- Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALSCompletedPhase 1Biohaven Pharmaceuticals, Inc.NCT03520517Written as BHV-0223
- Riluzole in Mild Alzheimer's DiseaseCompletedPhase 2Icahn School of Medicine at Mount SinaiNCT01703117Written as Riluzole
- Clinical Trial With Riluzole in Spinocerebellar Ataxia Type 2 (ATRIL)CompletedPhase 3Assistance Publique - Hôpitaux de ParisNCT03347344Written as Riluzole
- Safety Study of Riluzole to Treat Post-traumatic Stress Disorder (PTSD)CompletedPhase 1/2Uniformed Services University of the Health SciencesNCT02155829Written as Riluzole
See all 50 studies that test Riluzole →
Given beside what is tested · 20 — Riluzole is usual care or a partner of the new treatment
- Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral SclerosisNot yet recruitingPhase 2Huashan HospitalNCT07834450Written as Riluzole
- PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALSRecruitingPhase 2PhenoNet, Inc.NCT07142291Written as Riluzole (100 mg)
- Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)RecruitingPhase 1/2Biogipuzkoa Health Research InstituteNCT07414212Written as Riluzole
- Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS PatientsNot yet recruitingPhase 3AB ScienceNCT07174492Written as Riluzole (100 mg)
- Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS PatientsRecruitingPhase 3AB ScienceNCT03127267Written as Riluzole
- Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALSCompletedPhase 3Corestemchemon, Inc.NCT04745299Written as Riluzole
- MIROCALS: Modifying Immune Response and OutComes in ALSCompletedPhase 2Centre Hospitalier Universitaire de NīmesNCT03039673Written as Riluzole
- Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol)CompletedPhase 2InFlectis BioScienceNCT05508074Written as Riluzole 100mg/day
- Evaluate the Safety of Neuronata-R® Inj. Suspended With HypoTHermosol® FRS (HTS-FRS) in Patients With ALSCompletedPhase 1Corestemchemon, Inc.NCT06676423Written as Riluzole
- Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)CompletedPhase 2/3AB ScienceNCT02588677Written as Riluzole
- Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS)CompletedPhase 2MediciNovaNCT02238626Written as riluzole
- Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)CompletedPhase 2CytokineticsNCT01709149Written as Riluzole
- Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From ALSCompletedPhase 3Hoffmann-La RocheNCT00868166Written as Riluzole
- Research Study for Major Depressive Disorder: Investigation of Glutamate MedicationsCompletedPhase 4Baylor College of MedicineNCT00419003Written as Riluzole
- A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedPhase 2CytokineticsNCT01378676Written as Riluzole 50 MG (Part B)
- Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedPhase 2CytokineticsNCT01486849Written as Riluzole 50 MG
- Treatment Effect of Edaravone in Patients With Amyotrophic Lateral Sclerosis (ALS)Status unknownPhase 2/3Isfahan University of Medical SciencesNCT03272802Written as Riluzole
- Acetylcholine Receptors From Human Muscles as Pharmacological Target for ALSCompletedNot applicableUniversity of Roma La SapienzaNCT02645461Written as Riluzole
- Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)TerminatedPhase 2/3Massachusetts General HospitalNCT00818389Written as Riluzole
- Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)CompletedPhase 2/3University of LisbonNCT00353665Written as riluzole
As the comparator · 2 — what is tested is compared with Riluzole
- Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclerosis (ALS)TerminatedPhase 1/2Genuv Inc.NCT04326283Written as Riluzole (100 mg)
- Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral SclerosisCompletedEarly Phase 1Peking University Third HospitalNCT04454840Written as Riluzole
Codes
What other systems call Riluzole · ClinicalTrials.gg INT008713
- MeSH (NLM) D019782RiluzoleConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 7LJ087RS6FRILUZOLEConfirmed FDA, NLM, Wikidata
- RxNorm 35623Confirmed FDA, Wikidata
- Wikidata Q415744riluzoleConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C47704RiluzoleOne source FDA
- DrugBank DB00740One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D019782 | Riluzole | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 7LJ087RS6F | RILUZOLE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 35623 | — | Confirmed FDA, Wikidata |
| Wikidata | Q415744 | riluzole | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C47704 | Riluzole | One source FDA |
| DrugBank | DB00740 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.