Dysfunction of Respiratory Enzymes in Adults With Mental Illness (DREAM)

Inclusion Criteria:

• Aged 18 to 65 years.
• Able to provide informed consent and have an adequate command of English.
• For participants in the schizophrenia group: diagnosis of schizophrenia according to DSM-5 criteria.
• For control participants: no current or past mental disorder.
• For control participants: no family history of schizophrenia or psychosis.
• No history of head trauma resulting in loss of consciousness.
• For female participants: negative pregnancy test.
• No history of neurological disorder or past or present neurological illness.
• No drug, alcohol, or substance dependence, except nicotine.
• No significant medical or physical disorder or illness.
• No contraindications to MRI.
• Not currently breastfeeding.
• No participation in a clinical trial or receipt of an investigational product within 90 days, five half-lives, or twice the duration of the biological effect of the investigational product, whichever is longer.
• Negative blood test for glucose-6-phosphate dehydrogenase deficiency.
• Not taking an SSRI, MAOI, or other serotonergic drug in the 6 weeks before the study.
• No cardiac arrhythmia on screening ECG.
• No history of renal failure.
• No significant history of heart disease or ECG abnormality.