Drug
Leflunomide clinical trials
Also written Arava and SU101.
- studies test it
- 68
- open now
- 18
- in phase 3
- 9
- first study started
- 1997
Keep track of what changes. Save the Leflunomide studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
68 studies that test it; most in 2020 (7)
| Year | Studies |
|---|---|
| 1997 | 1 |
| 1998 | 1 |
| 1999 | 2 |
| 2001 | 1 |
| 2002 | 4 |
| 2003 | 4 |
| 2004 | 1 |
| 2005 | 1 |
| 2007 | 5 |
| 2009 | 1 |
| 2010 | 1 |
| 2012 | 5 |
| 2013 | 1 |
| 2015 | 4 |
| 2016 | 3 |
| 2018 | 1 |
| 2019 | 4 |
| 2020 | 7 |
| 2021 | 4 |
| 2022 | 4 |
| 2023 | 7 |
| 2024 | 4 |
| 2025 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 19
- Phase 2
- 22
- Phase 3
- 9
- Phase 4
- 13
- No phase
- 10
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 14 · Other 54
City of Hope Medical Center (10) · Sanofi (5) · Peking Union Medical College Hospital (3) · Teva Pharmaceuticals USA (2) · University of Nebraska (2) · Jawaharlal Institute of Postgraduate Medical Education & Research (2) · Par Pharmaceutical, Inc. (2) · Pfizer (2)
Often tested with
Tested in the same studies.
Sulfasalazine (9) · Methotrexate (8) · Hydroxychloroquine (8) · Prednisone (5) · Adalimumab (5) · Certolizumab Pegol (4) · Etanercept (4) · Azathioprine (3)
Studies
Open first, then newest update. How each study uses Leflunomide is read from its arms, and is right about nine times in ten.
Testing it · 68
- Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic CancerRecruitingPhase 1City of Hope Medical CenterNCT06454383Written as Leflunomide
- Leflunomide to Prevent Cytomegalovirus Reactivation in Stem Cell Transplant PatientsRecruitingPhase 2Tata Memorial CentreNCT07709013Written as Leflunomide 20 mg
- Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder ArthroplastyRecruitingPhase 2NYU Langone HealthNCT07138898Written as Leflunomide
- Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic MalignanciesRecruitingPhase 1City of Hope Medical CenterNCT05443425Written as Leflunomide
- Treatment of Rheumatoid Arthritis With DMARDs: Predictors of ResponseRecruitingPhase 3University of NebraskaNCT03414502Written as Leflunomide
- Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast CancerRecruitingPhase 1Deborah DoroshowNCT04997993Written as Leflunomide
- Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple MyelomaRecruitingPhase 2City of Hope Medical CenterNCT04508790Written as Leflunomide
- Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic SyndromesRecruitingPhase 1/2West Virginia UniversityNCT06923488Written as Leflunomide 10mg
- Treatment Strategies for IgG4-RD Patients With Superficial Organ InvolvementRecruitingNot applicablePeking Union Medical College HospitalNCT05789030Written as glucocorticoid plus leflunomide
- New Clinical End-points in Patients With Primary Sjögren's SyndromeRecruitingPhase 2Assistance Publique - Hôpitaux de ParisNCT05113004Written as Leflunomide 20mg/d
- Phase II Clinical Study of Leflunomide in the Treatment of MEN-1 Neuroendocrine TumorRecruitingPhase 2Cancer Institute and Hospital, Chinese Academy of Medical SciencesNCT06540937Written as Leflunomide Pill
- Treatment Strategies for IgG4-RD Patients With Internal Organ InvolvementRecruitingNot applicablePeking Union Medical College HospitalNCT05789017Written as Leflunomide
- Bioequivalence Study of Generic Leflunomide 20 mg Film-coated Tablets and Reference Product Under Fasting ConditionsNot yet recruitingPhase 1International Bio serviceNCT06228443Written as Leflunomide 20 mg Film-coated Tablet
- Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS MutationsRecruitingPhase 2N.N. Petrov National Medical Research Center of OncologyNCT06229340Written as Leflunomide
- Leflunomide for Henoch-Schonlein PurpuraRecruitingNot applicableSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT05937880Written as Leflunomide
- Leflunomide for Idiopathic Pulmonary Hemosiderosis in ChildrenRecruitingPhase 1/2Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT05937191Written as Leflunomide
- The Clinical Efficacy of Immunomodulators in RA PatientsRecruitingPhase 4Qilu Hospital of Shandong UniversityNCT05626348Written as Leflunomide
- Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic ArthritisRecruitingPhase 3University of Erlangen-Nürnberg Medical SchoolNCT04610476Written as Leflunomide
- Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host DiseaseActive, not recruitingPhase 1City of Hope Medical CenterNCT04212416Written as Leflunomide
- Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American PatientsActive, not recruitingPhase 2City of Hope Medical CenterNCT05014646Written as Leflunomide
See all 68 studies that test Leflunomide →
Given in every arm · 11 — Leflunomide is usual care beside what is tested
- Severe Psoriatic Arthritis - Early intervEntion to Control Disease: the SPEED TrialCompletedPhase 4University of OxfordNCT03739853Written as Leflunomide
- Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and BloodCompletedNot applicableChinese Academy of SciencesNCT01619176Written as leflunomide
- Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid ArthritisCompletedPhase 4SanofiNCT03449758Written as Leflunomide
- A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-α Therapy (SCRIPT)TerminatedPhase 3Genentech, Inc.NCT00476996Written as Leflunomide
- A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid ArthritisCompletedPhase 3Hoffmann-La RocheNCT01941095Written as Leflunomide
- A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis (SARIL-RA-HARUKA)CompletedPhase 3SanofiNCT02373202Written as Leflunomide
- To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET)CompletedPhase 3SanofiNCT01709578Written as leflunomide
- To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)CompletedPhase 3SanofiNCT01768572Written as leflunomide
- To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid ArthritisCompletedPhase 3SanofiNCT02057250Written as Leflunomide
- A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid ArthritisCompletedPhase 2Genentech, Inc.NCT01225393Written as leflunomide
- Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From "Real World"Status unknownPhase 4Fen LiNCT02878161Written as leflunomide (permitted, not necessary)
As the comparator · 5 — what is tested is compared with Leflunomide
- Psoriatic Oligoarthritis Intervention With Symptomatic thErapyCompletedPhase 4University of OxfordNCT03797872Written as Leflunomide
- A Clinical Study of Xin'an Medicine in the Treatment of Bi SyndromeCompletedNot applicableThe First Affiliated Hospital of Anhui University of Traditional Chinese MedicineNCT01774877Written as leflunomide
- Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid ArthritisStatus unknownPhase 4Jiangsu Simcere Pharmaceutical Co., Ltd.NCT02275299Written as Leflunomide
- A Study to Compare the Efficacy and Safety of Tacrolimus Capsules With Leflunomide Tablets in Lupus Nephritis PatientsTerminatedPhase 3Astellas Pharma IncNCT01342016Written as leflunomide tablet
- Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)WithdrawnPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00230035Written as Leflunomide
Codes
What other systems call Leflunomide · ClinicalTrials.gg INT006706
- MeSH (NLM) D000077339LeflunomideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) G162GK9U4WLEFLUNOMIDEConfirmed FDA, NLM, Wikidata
- RxNorm 27169Confirmed FDA, Wikidata
- Wikidata Q248550leflunomideConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1128LeflunomideOne source FDA
- DrugBank DB01097One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077339 | Leflunomide | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | G162GK9U4W | LEFLUNOMIDE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 27169 | — | Confirmed FDA, Wikidata |
| Wikidata | Q248550 | leflunomide | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1128 | Leflunomide | One source FDA |
| DrugBank | DB01097 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.