Immunoglobulin G4-Related Disease clinical trials
The registry lists 72 studies for Immunoglobulin G4-Related Disease across more than 10 countries. 40 are recruiting or about to start. 53 of them are mainly about Immunoglobulin G4-Related Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Peking Union Medical College Hospital (14) · Meir Medical Center (4) · Chinese PLA General Hospital (3) · Wen Zhang (3) · Tongji Hospital (3) · Assistance Publique Hopitaux De Marseille (2) · Peking University People's Hospital (2) · Amgen (2)
What is being tested here
Drugs under test in Immunoglobulin G4-Related Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Mycophenolic Acid | 2 | 0 | 4 |
| Lenalidomide | 2 | 2 | 3 |
| Leflunomide | 2 | 0 | 3 |
| Inebilizumab | 1 | 1 | 2 |
| Rilzabrutinib | 1 | 1 | 2 |
| Tripterygium wilfordii | 1 | 0 | 1 |
| Amulirafusp alfa | 1 | 1 | 1 |
| Sirolimus | 1 | 0 | 1 |
| Imiquimod | 1 | 0 | 1 |
| YTS109 | 1 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open · JAK inhibitors 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases · UMC Utrecht
- Dec 2026National Registry of IgG4-RD in China · Peking Union Medical College Hospital
- Dec 2026Study of Sirolimus in IgG4-related Disease · Peking University International Hospital
- Dec 2026The BCMA/CD19 Dual Targeted CAR-T Cell in Participants With Autoimmune Kidney Diseases · Nanjing University School of Medicine
- May 2027UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune Diseases · Changzhou No.2 People's Hospital
- May 2027A Clinical Study of YTS109 Cell in R/R Autoimmune Diseases · China Immunotech (Beijing) Biotechnology Co., Ltd.
- Jun 2027Dermal Priming in Enhancing Vaccine Immunogenicity · Cambridge University Hospitals NHS Foundation Trust
- Jul 2027Safety and Efficacy of PRG-1801 for Refractory Lupus Nephritis and IgG4-Related Disease · Tongji Hospital
- Jul 2027Safety and Efficacy of PRG-2311 for Refractory Lupus Nephritis and IgG4-Related Disease · Tongji Hospital
- Sep 2027Exploratory Study of Anti-BCMA-CD19 CAR-T Cell Therapy in Relapsed or Refractory IgG4-Related Disease · Chinese PLA General Hospital
Who these studies take
Of the 28 Immunoglobulin G4-Related Disease studies recruiting now, 12 (43%) set no upper age limit and 13 (46%) stop at 75 or younger. 3 (11%) take children under 18. 0 (0%) are for women only and 1 (4%) for men only; 3 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (11%) | 3 (11%) |
| 18 | 27 (96%) | 27 (96%) |
| 30 | 26 (93%) | 26 (93%) |
| 40 | 26 (93%) | 26 (93%) |
| 50 | 26 (93%) | 27 (96%) |
| 65 | 26 (93%) | 27 (96%) |
| 75 | 21 (75%) | 22 (79%) |
| 85 | 12 (43%) | 13 (46%) |
Across all 72 studies, recruiting or not: 40% stop at 75 or younger and 10% at 65; 6% take children; 0% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
Newly registered3
- Dermal Priming in Enhancing Vaccine ImmunogenicityNov 9, 2026NCT07925996
- Whole-Body ⁶⁸Ga-FAPI PET/CT in Cavernous Sinus Syndrome: A Prospective Comparison With ¹⁸F-FDG PET/CTNov 5, 2026NCT07917858
- Tripterygium Wilfordii Plus Prednisone for Active IgG4-Related DiseaseOct 16, 2026NCT07878585
Studies
Recruiting first, then most recently updated. Showing 50 of 72. Browse all 72 → or search them.
- Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Inebilizumab in Pediatric Participants With IgG4-RDRecruitingNCT07222553Phase 28 countries
- Dermal Priming in Enhancing Vaccine ImmunogenicityRecruitingNCT07925996Not applicable1 country
- A Clinical Study of YTS109 Cell in R/R Autoimmune DiseasesRecruitingNCT06978647Phase 11 country
- A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related DiseaseRecruitingNCT07190196Phase 319 countries
- Tripterygium Wilfordii Plus Prednisone for Active IgG4-Related DiseaseNot yet recruitingNCT07878585Phase 21 country
- Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related DiseaseRecruitingNCT07061938Phase 1/23 countries
- Comparative Autoantibody and Immunologic Cell Marker StudyEnrolling by invitationNCT024228751 country
- Nebulized UC-EVs for Recurrent or Refractory IMIDs With Lung InvolvementNot yet recruitingNCT07806045Early Phase 11 country
- BCT301 in Treating Refractory/Recurrent IgG4-related DiseaseNot yet recruitingNCT07793903Not applicable
- Efficacy and Safety of Lenalidomide in Patients With IgG4-Related DiseaseNot yet recruitingNCT07719543Phase 31 country
- The BCMA/CD19 Dual Targeted CAR-T Cell in Participants With Autoimmune Kidney DiseasesRecruitingNCT06285279Phase 11 country
- A Study of IMM0306 in IgG4-Related DiseaseNot yet recruitingNCT07621939Phase 2/3
- Validation of the Odesa Criteria 2026 for Autoimmune PancreatitisRecruitingNCT075368411 country
- A Study to Evaluate MTM-H-001 Injection in Adult Patients With B-Cell-Related Autoimmune DiseasesNot yet recruitingNCT07593911Not applicable1 country
- Drug Rediscovery for Rare Immune Mediated Inflammatory DiseasesRecruitingNCT06285539Phase 21 country
- The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.RecruitingNCT07535554Phase 2/31 country
- Treatment Strategies for IgG4-RD Patients With Superficial Organ InvolvementRecruitingNCT05789030Not applicable1 country
- Institutional Registry of Rare DiseasesRecruitingNCT065737231 country
- A Randomized Controlled Study of the Efficacy and Safety of Lenalidomide in the Treatment of Active IgG4-related DiseaseRecruitingNCT07068165Phase 2/31 country
- An Exploratory Clinical Study on the Safety and Efficacy of CD19/BCMA CAR-NK in the Treatment of Relapsed and Refractory IgG4-related DiseaseNot yet recruitingNCT07298590Early Phase 11 country
- Exploratory Study of Anti-BCMA-CD19 CAR-T Cell Therapy in Relapsed or Refractory IgG4-Related DiseaseRecruitingNCT07148791Phase 21 country
- A Study on the Effect of MRD Detected by FAPI PET / CT on the Recurrence of IgG4-RDRecruitingNCT07104058Not applicable1 country
- UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune DiseasesNot yet recruitingNCT06978738Phase 11 country
- AYLo - AutoimmunitY and Loss of yRecruitingNCT066960271 country
- BCMA-CD19 CAR-T Therapy for Refractory Autoimmune DiseasesRecruitingNCT06794008Phase 21 country
- Short-term Glucocorticoid Combined with MMF for IgG4-RDRecruitingNCT06663618Not applicable1 country
- Key Mechanisms of Abnormal T Cell Activation and Differentiation in IgG4-Related Ophthalmic DiseaseNot yet recruitingNCT06655831
- Safety and Efficacy of PRG-1801 for Refractory Lupus Nephritis and IgG4-Related DiseaseRecruitingNCT06497387Early Phase 11 country
- Safety and Efficacy of PRG-2311 for Refractory Lupus Nephritis and IgG4-Related DiseaseRecruitingNCT06497361Early Phase 11 country
- Study of the C5a/C5aR1 Axis in IgG4-associated Disease: a Potential Therapeutic TargetNot yet recruitingNCT06270524Not applicable
- Treatment Strategies for IgG4-RD Patients With Internal Organ InvolvementRecruitingNCT05789017Not applicable1 country
- Diagnostic and Prognostic Biomarkers for IgG4-related Disease.RecruitingNCT059012071 country
- Early Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune DiseasesRecruitingNCT06361745Not applicable1 country
- Baricitinib Plus Glucocorticoid for Eosinophilia in IgG4-RDRecruitingNCT05781516Not applicable1 country
- Study of Sirolimus in IgG4-related DiseaseNot yet recruitingNCT05746689Not applicable
- Immunoglobulin G4 and Immunoglobulin E Antibodies in a Population With Adverse Reactions to Foodstuffs-related SymptomsRecruitingNCT056819751 country
- Tofatib Treatment for IgG4-related DiseaseRecruitingNCT056255811 country
- Meir Medical Center Rheumatologic BiobankRecruitingNCT034739121 country
- A Prospective Cohort Study of IgG4RD in ChinaRecruitingNCT016706951 country
- National Registry of IgG4-RD in ChinaRecruitingNCT030233711 country
- Whole-Body ⁶⁸Ga-FAPI PET/CT in Cavernous Sinus Syndrome: A Prospective Comparison With ¹⁸F-FDG PET/CTActive, not recruitingNCT079178581 country
- A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Autoimmune DiseasesWithdrawnNCT07583030Early Phase 11 country
- Tofacitinib in the Treatment of IgG4 Related DiseasesCompletedNCT07827469Not applicable1 country
- the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory Autoimmune DiseasesActive, not recruitingNCT07339540Early Phase 11 country
- A Study of Efgartigimod in Patients With IgG4-Related DiseaseActive, not recruitingNCT07025330Phase 21 country
- Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related DiseaseCompletedNCT02899039Not applicable1 country
- Zanubrutinib in Patients With IgG4-Related DiseaseCompletedNCT04602598Phase 21 country
- Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)TerminatedNCT04918147Phase 21 country
- A Phase 3 Study of Obexelimab in Patients With IgG4-Related DiseaseActive, not recruitingNCT05662241Phase 315 countries
- A Study of Inebilizumab Efficacy and Safety in IgG4- Related DiseaseActive, not recruitingNCT04540497Phase 321 countries