Triple Negative Breast Neoplasms clinical trials
The registry lists 1,219 studies for Triple Negative Breast Neoplasms across more than 10 countries. 445 are recruiting or about to start. 857 of them are mainly about Triple Negative Breast Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 1,517 studies for Triple Negative Breast Neoplasms. How that becomes 1,219 here
This page counts the studies the registry files under Triple Negative Breast Neoplasms, and those it files under no condition that list Triple Negative Breast Neoplasmsthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,517Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −8List Triple Negative Breast Neoplasms as a condition, but the registry did not file them under itMost often written as “Advanced Triple Negative Breast Cancer” (2), “Triple Negative Breast Cancer Patients” (1), and “Advanced, Androgen Receptor Positive Triple Negative Breast Cancer” (1). The registry filed them under other conditions only, most often Breast Neoplasms (4) and Carcinoma, Non-Small-Cell Lung (1).
- −290Match it another way201 name it in the title and 89 by a synonym or other text the search reads.
- 1,219The count on this page17 of them list Triple Negative Breast Neoplasms in their own words; the registry filed them under no condition.
Get an email when these change. Save the Triple Negative Breast Neoplasms studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Fudan University (65) · National Cancer Institute (NCI) (45) · M.D. Anderson Cancer Center (29) · Novartis Pharmaceuticals (22) · AstraZeneca (14) · Merck Sharp & Dohme LLC (14) · City of Hope Medical Center (11) · Pfizer (11)
What is being tested here
Drugs under test in Triple Negative Breast Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Immune checkpoint inhibitors 78 open · Antimitotic agents 27 open · Antibody-drug conjugates (ADCs) 26 open · Tyrosine kinase inhibitors (TKIs) 16 open · PARP inhibitors 14 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Randomized Controlled Trial of Neoadjuvant Weekly Paclitaxel Versus Weekly Paclitaxel Plus Weekly Carboplatin In Women With Large Operable or Locally Advanced, Triple Negative Breast Cancer · Phase 3 · Tata Memorial Hospital
- Dec 2026AK112 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/ Metastatic Triple-negative Breast Cancer · Phase 3 · Akeso
- Dec 2026PARPi or Capecitabine Combined With PD-1 Inhibitors as Adjuvant Therapy in High-risk TNBC · Phase 3 · Guangdong Provincial People's Hospital
- Feb 2027Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer · Phase 3 · Gilead Sciences
- Mar 2027Sacituzumab Govitecan in Primary HER2-negative Breast Cancer · Phase 3 · GBG Forschungs GmbH
- Apr 2027A Study of SKB264 Versus Investigator's Choice Chemotherapy in Patients With Unresectable Recurrent or Metastatic Triple-Negative Breast Cancer · Phase 3 · Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
- Jun 2027Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63) · Phase 3 · Gilead Sciences
- Jun 2027A Phase III Study of ESG401 for Unresectable Recurrent or Metastatic Triple-Negative Breast Cancer · Phase 3 · Qilu Pharmaceutical Co., Ltd.
- Jun 2027Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer(UPGRADE-TNBC) · Phase 3 · Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Jul 2027PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/Metastatic TNBC · Phase 3 · Biotheus Inc.
Who these studies take
Of the 331 Triple Negative Breast Neoplasms studies recruiting now, 231 (70%) set no upper age limit and 85 (26%) stop at 75 or younger. 12 (4%) take children under 18. 106 (32%) are for women only and 0 (0%) for men only; 6 (2%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (2%) | 5 (2%) |
| 18 | 322 (97%) | 218 (66%) |
| 30 | 328 (99%) | 223 (67%) |
| 40 | 330 (100%) | 224 (68%) |
| 50 | 330 (100%) | 224 (68%) |
| 65 | 329 (99%) | 223 (67%) |
| 75 | 283 (85%) | 213 (64%) |
| 85 | 240 (73%) | 192 (58%) |
Across all 1,219 studies, recruiting or not: 19% stop at 75 or younger and 2% at 65; 2% take children; 37% are for women only and <1% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Triple Negative Breast Neoplasms studies take
Of 255 phase 2 interventional studies under Triple Negative Breast Neoplasms, half reached primary completion within 59 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 54 mo35–80 · 208 studies | 53 mo32–70 · 135 studies | 58 mo37–96 · 73 studies |
| Phase 1/2 | 56 mo43–79 · 118 studies | 54 mo44–77 · 70 studies | — |
| Phase 2 | 59 mo37–94 · 255 studies | — | 60 mo38–99 · 220 studies |
| Phase 3 | 65 mo39–103 · 60 studies | — | — |
| Interventional, no phase | 82 mo36–… · 49 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting4
- A Study of ITC-6146RO in Patients With Advanced or Metastatic Cancer Who Have Failed Standard TherapyNov 10, 2026NCT07423117
- A Clinical Study to Evaluate the Efficacy and Safety of JS212 Monotherapy or Combination Therapy in Recurrent or Metastatic Triple-negative Breast Cancer(TNBC)Nov 5, 2026NCT07876557
- SC-101 in Subjects With Advanced NECTIN4-Amplified CancersOct 29, 2026NCT07080619
- Enhancing ICB Efficacy Through IL-1 Inhibition in TNBCOct 29, 2026NCT07698106
Results posted4
- [18F]-DPA-714 PET/CT (Positron Emission Tomography/Computerized Tomography) in Triple Negative Breast CancersNov 10, 2026NCT04320030
- Abemaciclib in Treating Patients With Surgically Resectable, Chemotherapy Resistant, Triple Negative Breast CancerNov 2, 2026NCT03979508
- PRO1107 in Patients With Advanced Solid TumorsOct 29, 2026NCT06171789
- Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)Oct 22, 2026NCT03036488
Newly registered8
- Dexamethasone De-Escalation in Neoadjuvant Chemoimmunotherapy for Triple-Negative Breast CancerNov 3, 2026NCT07914309
- A Study of MDSY-1240, a STAT3 Degrader, for the Treatment of Hematologic Malignancies and Advanced Solid TumorsOct 27, 2026NCT07899632
- A Study to Evaluate YF550 in Participants With Locally Advanced or Metastatic Solid Tumors.Oct 26, 2026NCT07894874
- Fasten Onco Digital Therapy During Neoadjuvant Treatment for Triple-Negative Breast CancerOct 21, 2026NCT07884721
- Thymalfasin Combined With Chemotherapy and Immunotherapy in TNBC Neoadjuvant TreatmentOct 20, 2026NCT07884201
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- A Study of SYS6043 Versus Investigator's Choice Chemotherapy as First-Line Treatment in Patients With Unresectable Locally Recurrent or Metastatic Triple-Negative Breast CancerOct 19, 2026NCT07879911
- Pre-Treatment Breast DCE-MRI AI Model to Predict Neoadjuvant Chemotherapy Benefit in Locally Advanced Triple-Negative Breast CancerOct 19, 2026NCT07880600
- A Clinical Study to Evaluate the Efficacy and Safety of JS212 Monotherapy or Combination Therapy in Recurrent or Metastatic Triple-negative Breast Cancer(TNBC)Oct 15, 2026NCT07876557
Studies
Recruiting first, then most recently updated. Showing 50 of 1,219. Browse all 1,219 → or search them.
- Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain MetastasesRecruitingNCT076195341 country
- A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid TumorsRecruitingNCT06270706Phase 12 countries
- Phase 3 Trial of SRG-514 Administered Intraoperatively to Patients Undergoing Breast-Conserving SurgeryNot yet recruitingNCT07723469Phase 31 country
- Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast CancerRecruitingNCT05422794Phase 11 country
- Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast CancerRecruitingNCT03606967Phase 21 country
- GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Relapsed/Refractory GPNMB-Expressing Solid TumoursRecruitingNCT07297667Phase 11 country
- Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast CancerRecruitingNCT05111561Phase 11 country
- A Study of ITC-6146RO in Patients With Advanced or Metastatic Cancer Who Have Failed Standard TherapyRecruitingNCT07423117Phase 11 country
- A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors TypesRecruitingNCT07503808Phase 13 countries
- A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)RecruitingNCT06966700Phase 341 countries
- A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)RecruitingNCT06841354Phase 335 countries
- Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast CancerNot yet recruitingNCT07217990Phase 1/21 country
- START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of CancerRecruitingNCT05492682Phase 12 countries
- Phase 1 Study of a Self-amplifying RNA Vaccine (ITI-5000) in Stage 2-3 Triple Negative Breast CancerRecruitingNCT07652242Phase 11 country
- A Study of MR001 in Patients With Locally Recurrent or Metastatic Advanced Triple-Negative Breast Cancer (TNBC)RecruitingNCT07208149Phase 1/21 country
- A Study of Camrelizumab Plus Chemotherapy in Combination With or Without Famitinib as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (BCTOP-T-N01)RecruitingNCT05999149Phase 31 country
- BrAin Metastasis in tripLe Negateive Breast Cancer: IvoneScimab and Trop2 ADCRecruitingNCT06793332Phase 21 country
- A Study With NKT3964 for Adults With Advanced/Metastatic Solid TumorsRecruitingNCT06586957Phase 12 countries
- A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid TumorsRecruitingNCT07318805Phase 13 countries
- A Clinical Study to Evaluate the Efficacy and Safety of JS212 Monotherapy or Combination Therapy in Recurrent or Metastatic Triple-negative Breast Cancer(TNBC)RecruitingNCT07876557Phase 21 country
- Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)RecruitingNCT06393374Phase 331 countries
- Personalized Cancer Vaccine (PCV) Strategy in Triple Negative Breast Cancer PatientsNot yet recruitingNCT07300475Phase 11 country
- A Study With NKT5097 for Adults With Advanced/Metastatic Solid TumorsRecruitingNCT07029399Phase 11 country
- Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)RecruitingNCT05633654Phase 312 countries
- Posaconazole Plus PD-1 Inhibitors and Chemotherapy vs PD-1 Inhibitors and Chemotherapy in Neoadjuvant Therapy for Triple Negative Breast CancerRecruitingNCT06802757Phase 21 country
- A Study of Sofe-M in Participants With Selected Advanced Solid TumorsRecruitingNCT06400472Phase 17 countries
- A Phase 1 of CTX-8371 in Patients With Advanced MalignanciesRecruitingNCT06150664Phase 11 country
- Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)RecruitingNCT05579366Phase 1/24 countries
- A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid TumorsRecruitingNCT06465069Phase 18 countries
- US/PA/E Imaging for Early Identification of Tumor Response in Patients With Stage II-III Triple Negative Breast Cancer Receiving Neoadjuvant Immunotherapy and ChemotherapyNot yet recruitingNCT07862751Phase 21 country
- Deployment and Clinical Evaluation of an AI-powered Digital Oncology Biomarker Tool to guidE Treatment in TNBCNot yet recruitingNCT06396754
- Dexamethasone De-Escalation in Neoadjuvant Chemoimmunotherapy for Triple-Negative Breast CancerNot yet recruitingNCT07914309Phase 21 country
- 177Lu-anti-PD-L1 sdAb in Metastatic Solid TumorsRecruitingNCT06305962Early Phase 11 country
- Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null PhenotypeRecruitingNCT07341867Phase 11 country
- Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ TILSRecruitingNCT05451784Phase 1/21 country
- Study of XB010 in Subjects With Solid TumorsRecruitingNCT06545331Phase 12 countries
- Ivermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer and HR+/HER2- Metastatic Breast CancerRecruitingNCT05318469Phase 1/21 country
- Enhancing ICB Efficacy Through IL-1 Inhibition in TNBCRecruitingNCT07698106Phase 1/21 country
- SC-101 in Subjects With Advanced NECTIN4-Amplified CancersRecruitingNCT07080619Phase 21 country
- A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCsRecruitingNCT06908928Phase 11 country
- A Study of MDSY-1240, a STAT3 Degrader, for the Treatment of Hematologic Malignancies and Advanced Solid TumorsNot yet recruitingNCT07899632Phase 1/2
- A Study to Evaluate YF550 in Participants With Locally Advanced or Metastatic Solid Tumors.Not yet recruitingNCT07894874Phase 1
- Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell ManufacturingRecruitingNCT049811191 country
- Reverse Triple Negative Immune Resistant Breast CancerRecruitingNCT05076682Phase 21 country
- Intratumoral INT230-6 Followed by Neoadjuvant Immuno-chemotherapy in Patients With Early TNBC. INVINCIBLE-4-SAKKRecruitingNCT06358573Phase 22 countries
- A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid TumorsRecruitingNCT07705334Phase 11 country
- Fasten Onco Digital Therapy During Neoadjuvant Treatment for Triple-Negative Breast CancerNot yet recruitingNCT07884721Not applicable1 country
- Intratumoral N17350 in Advanced Solid TumorsRecruitingNCT07339176Phase 1/22 countries
- Thymalfasin Combined With Chemotherapy and Immunotherapy in TNBC Neoadjuvant TreatmentNot yet recruitingNCT07884201Phase 2
- A Study of SYS6043 Versus Investigator's Choice Chemotherapy as First-Line Treatment in Patients With Unresectable Locally Recurrent or Metastatic Triple-Negative Breast CancerNot yet recruitingNCT07879911Phase 3