Drug class
Histone Deacetylase Inhibitors clinical trials
A class of medicines: the studies that test any of its 46 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Keep track of what changes. Save the histone deacetylase inhibitors studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesMedicines in this class
Studies that test each. A study of two counts under both, and once above.
- Trichostatin A
- 2
- Bocodepsin besylate
- 2
- CKD-506
- 2
- KA-2507
- 2
- Imofinostat
- 2
- CKD-581
- 2
- CHR 2845
- 2
- HDAC Class I/IIb Inhibitor HG146
- 2
- CoREST Inhibitor TNG260
- 1
- Ivaltinostat phosphate
- 1
And 6 more, each tested in fewer studies.
Studies by the year they started
1,234 studies that test it; most in 2009 (82); 2 more planned to start later
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1994 | 1 |
| 1996 | 1 |
| 1997 | 8 |
| 1999 | 2 |
| 2000 | 12 |
| 2001 | 7 |
| 2002 | 7 |
| 2003 | 32 |
| 2004 | 44 |
| 2005 | 61 |
| 2006 | 78 |
| 2007 | 60 |
| 2008 | 74 |
| 2009 | 82 |
| 2010 | 76 |
| 2011 | 53 |
| 2012 | 42 |
| 2013 | 50 |
| 2014 | 38 |
| 2015 | 38 |
| 2016 | 70 |
| 2017 | 56 |
| 2018 | 43 |
| 2019 | 35 |
| 2020 | 34 |
| 2021 | 36 |
| 2022 | 52 |
| 2023 | 35 |
| 2024 | 37 |
| 2025 | 35 |
| 2026 | 34 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 319 · Other 923
National Cancer Institute (NCI) (133) · M.D. Anderson Cancer Center (40) · Novartis Pharmaceuticals (39) · Merck Sharp & Dohme LLC (26) · Italfarmaco (24) · Sun Yat-sen University (20) · H. Lee Moffitt Cancer Center and Research Institute (18) · Syndax Pharmaceuticals (18)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten.
Testing one of them · 1,242
- A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and ToxicityRecruitingPhase 2National Cancer Institute (NCI)NCT06406465Written as Belinostat
- A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GlioblastomaRecruitingPhase 2/3Global Coalition for Adaptive ResearchNCT03970447Written as Tinostamustine
- Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical PatientsRecruitingNot applicableChinese University of Hong KongNCT07144033Written as Butyrate and Taurine
- Study of Sodium Phenylbutyrate (ACER-001) for the Treatment of Pediatric and Adults Patients With Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD)RecruitingPhase 2Jerry Vockley, MD, PhDNCT06773026Written as Sodium phenylbutyrate
- Tucidinostat in Combination With CHOP in Newly Diagnosed Peripheral T-Cell Lymphoma With Follicular Helper of T Cell PhenotypeRecruitingPhase 3Chipscreen Biosciences, Ltd.NCT06947967Written as Tucidinostat
- Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) PopulationRecruitingPhase 2Sung Won ChoiNCT06995521Written as Vorinostat
- Venetoclax Combined With Azacitidine, Chidamide, Vindesine, and Dexamethasone in Newly Diagnosed ETP-ALL Like PatientsRecruitingPhase 2The First Affiliated Hospital of Soochow UniversityNCT07159620Written as Chidamide
- An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With UstekinumabRecruitingPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT03167437Written as Vorinostat
- BEBT-908 in MEF2D-Rearranged Relapsed/Refractory or MRD-Positive B-Cell Precursor Acute Lymphoblastic LeukemiaRecruitingPhase 1The First Affiliated Hospital of Soochow UniversityNCT07854652Written as Ifupinostat Hydrochloride
- Clinical Trial of HG146 Administered to Participants With Adenoid Cystic CarcinomaRecruitingPhase 2HitGen Inc.NCT06781567Written as HG146
- VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent GliomaRecruitingPhase 2Inova Health Care ServicesNCT07831369Written as Valproic Acid (VPA)
- Rett REVOLUTION Trial: An Exploratory Evaluation of the Safety and Efficacy of Vorinostat in Rett SyndromeRecruitingPhase 1Unravel Biosciences, Inc.NCT07150013Written as Vorinostat (SAHA)
- An Exploratory Evaluation of the Safety and Efficacy of Vorinostat in Pitt Hopkins SyndromeRecruitingPhase 1Unravel Biosciences, Inc.NCT07150026Written as Vorinostat (SAHA)
- A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent GliomaRecruitingPhase 1University of NebraskaNCT05698524Written as PCI 24781
- Effects of Butyrate Enemas on Postoperative Intestinal Motility Disorders in Hirschsprung's DiseaseNot yet recruitingPhase 3Assistance Publique Hopitaux De MarseilleNCT03660176Written as Sodium Butyrate
- Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and OsteosarcomaRecruitingPhase 1/2H. Lee Moffitt Cancer Center and Research InstituteNCT07725380Written as Domatinostat
- Seizure Treatment in GliomaRecruitingPhase 4Leiden University Medical CenterNCT03048084Written as Valproic Acid
- A Study of Chidamide Combined With Ivonescimab in the Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) With Acquired Resistance to Immunotherapy and High Yes-associated Protein (YAP) ExpressionRecruitingPhase 2Guangdong Association of Clinical TrialsNCT07412262Written as Chidamide in combination with Ivonescimab
- NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + DinutuximabNot yet recruitingPhase 2New Approaches to Neuroblastoma Therapy ConsortiumNCT07261241Written as Vorinostat
- Venetoclax-Azacitidine in Combination With Chidamide and CAG in Fit Older Patients With Acute Myeloid LeukaemiaRecruitingPhase 3Chinese PLA General HospitalNCT07514936Written as Azacytidine; Cytarabine; Aclacinomycin; Chidamide; Venetoclax; Granulocyte
See all 1,242 studies that test one of the histone deacetylase inhibitors →