Drug
Entinostat clinical trials
Also written SNDX-275 and MS-275.
- studies test it
- 69
- open now
- 6
- in phase 3
- 2
- first study started
- 2001
Keep track of what changes. Save the entinostat studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Combined with it in one product
Studies by the year they started
69 studies that test it; most in 2017 (12)
| Year | Studies |
|---|---|
| 2001 | 2 |
| 2004 | 2 |
| 2006 | 1 |
| 2008 | 5 |
| 2009 | 2 |
| 2010 | 6 |
| 2011 | 2 |
| 2012 | 2 |
| 2013 | 3 |
| 2014 | 2 |
| 2015 | 1 |
| 2016 | 9 |
| 2017 | 12 |
| 2018 | 5 |
| 2019 | 3 |
| 2020 | 3 |
| 2021 | 3 |
| 2022 | 1 |
| 2024 | 1 |
| 2025 | 2 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 41
- Phase 2
- 37
- Phase 3
- 2
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 23 · Other 46
National Cancer Institute (NCI) (22) · Syndax Pharmaceuticals (18) · Roberto Pili (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · UNC Lineberger Comprehensive Cancer Center (2) · Abramson Cancer Center at Penn Medicine (2) · Taizhou EOC Pharma Co., Ltd. (2) · Tianjin Medical University Cancer Institute and Hospital (2)
Often tested with
Tested in the same studies.
Azacitidine (7) · Pembrolizumab (6) · Nivolumab (5) · Atezolizumab (3) · Ipilimumab (2) · Bevacizumab (2) · Exemestane (2) · Fulvestrant (2)
Studies
Open first, then newest update. How each study uses entinostat is read from its arms, and is right about nine times in ten.
Testing it · 69
- Entinostat Plus Pyrotinib and Endocrine Therapy in Advanced Triple-Positive Breast Cancer After Trastuzumab FailureRecruitingPhase 1/2Tianjin Medical University Cancer Institute and HospitalNCT07708194Written as entinostat
- Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid TumorsRecruitingPhase 1/2National Cancer Institute (NCI)NCT05053971Written as Entinostat
- A Single-arm, Prospective, Phase II Clinical Study of the Combination of Entinostat and Oral Paclitaxel in the Treatment of HR+HER2- Advanced Breast CancerNot yet recruitingPhase 2Tianjin Medical University Cancer Institute and HospitalNCT07441486Written as Entinostat
- Entinostat & Chemotherapy for Locally Advanced or Metastatic Bladder CancerNot yet recruitingPhase 1/2The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNCT07261592Written as Entinostat
- A Study of Entinostat in Combination With Fulvestrant for the Treatment of Locally Advanced or Metastatic Breast CancerNot yet recruitingPhase 2Sun Yat-sen UniversityNCT07235618Written as Entinostat
- INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory MalignanciesRecruitingPhase 1/2University Hospital HeidelbergNCT03838042Written as Nivolumab and Entinostat
- Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or MetastaticActive, not recruitingPhase 3National Cancer Institute (NCI)NCT02115282Written as Entinostat
- Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory LymphomasActive, not recruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT03179930Written as Entinostat
- Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast CancerActive, not recruitingPhase 1National Cancer Institute (NCI)NCT02453620Written as Entinostat
- Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney CancerActive, not recruitingPhase 1/2National Cancer Institute (NCI)NCT01038778Written as Entinostat
- Entinostat Neuroendocrine (NE) TumorTerminatedPhase 2Antonio FojoNCT03211988Written as Entinostat
- A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast CancerCompletedPhase 1/2Hoffmann-La RocheNCT03280563Written as Entinostat
- Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has SpreadCompletedPhase 1National Cancer Institute (NCI)NCT04631029Written as Entinostat
- A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic AdenocarcinomaCompletedPhase 2Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT03250273Written as Entinostat
- Azacitidine and Entinostat in Treating Patients With Advanced Breast CancerCompletedPhase 2National Cancer Institute (NCI)NCT01349959Written as Entinostat
- Testing the Safety and Efficacy of the Combination of the Antibody Pembrolizumab and Entinostat in Patients With Myelodysplastic Syndrome Who Are Not Responding to Hypomethylating AgentsCompletedPhase 1National Cancer Institute (NCI)NCT02936752Written as Entinostat
- Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)CompletedPhase 1/2Syndax PharmaceuticalsNCT02437136Written as entinostat
- Atezolizumab in Combination With Entinostat and Bevacizumab in Patients With Advanced Renal Cell CarcinomaTerminatedPhase 1/2Roberto PiliNCT03024437Written as Entinostat
- Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead InCompletedPhase 1/2Syndax PharmaceuticalsNCT02708680Written as Entinostat
- Study of Entinostat With Nivolumab Plus Ipilimumab in Previously Treated Renal Cell CarcinomaTerminatedPhase 2Roberto PiliNCT03552380Written as Entinostat
See all 69 studies that test entinostat →
Given in every arm · 7 — entinostat is usual care beside what is tested
- Preliminary Clinical Study of Entinostat in Children With Malignant Soft Tissue Sarcoma Harboring PAX-family Gene AbnormalitiesRecruitingPhase 1Beijing Tongren HospitalNCT07888114Written as Entinostat
- A Phase II Clinical Study Evaluating Entinostat With or Without Anlotinib + Fulvestrant for the Treatment of Hormone Receptor (HR) -Positive, Human Epidermal Growth Factor Receptor-2 (HER-2) -Negative Advanced Breast Cancer That Relapsed or Progressed After Endocrine TherapyRecruitingPhase 2Zhejiang Cancer HospitalNCT07330544Written as entinostat
- Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder CancerActive, not recruitingPhase 2UNC Lineberger Comprehensive Cancer CenterNCT03978624Written as Entinostat
- A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon CancersCompletedPhase 1/2National Cancer Institute (NCI)NCT04708470Written as Entinostat
- Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung CancerCompletedPhase 1/2National Cancer Institute (NCI)NCT00387465Written as Entinostat
- MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic LeukemiaCompletedPhase 2National Cancer Institute (NCI)NCT00462605Written as entinostat
- MS-275 and Isotretinoin in Treating Patients With Metastatic or Advanced Solid Tumors or LymphomasCompletedPhase 1National Cancer Institute (NCI)NCT00098891Written as entinostat
Codes
What other systems call entinostat · ClinicalTrials.gg INT004149
- MeSH (NLM) C118739entinostatConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 1ZNY4FKK9HENTINOSTATConfirmed FDA, NLM, Wikidata
- Wikidata Q1281020entinostatConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1863EntinostatOne source FDA
- DrugBank DB11841One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C118739 | entinostat | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 1ZNY4FKK9H | ENTINOSTAT | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q1281020 | entinostat | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1863 | Entinostat | One source FDA |
| DrugBank | DB11841 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.