Drug
Epoprostenol clinical trials
Also written Flolan® and Prostacyclin.
How studies write it
Studies that test it under each name
Studies by the year they started
15 studies that test it; most in 2010 (3)
| Year | Studies |
|---|---|
| 1993 | 1 |
| 2004 | 1 |
| 2005 | 1 |
| 2006 | 1 |
| 2007 | 1 |
| 2010 | 3 |
| 2011 | 3 |
| 2012 | 1 |
| 2014 | 1 |
| 2020 | 2 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 5 · Other 10
Actelion (3) · Aerogen Pharma Limited (1) · Universitaire Ziekenhuizen KU Leuven (1) · GlaxoSmithKline (1) · Stanford University (1) · Yonsei University (1) · Rune Rasmussen (1) · Free University Medical Center (1)
Often tested with
Tested in the same studies.
Antithrombin-III (1) · Antithrombin III (1) · Infliximab (1) · Apotransferrin (1) · Complement C1 Inhibitor Protein (1) · Glutathione (1) · Melatonin (1) · Nitric Oxide (1)
Studies
Open first, then newest update. How each study uses Epoprostenol is read from its arms, and is right about nine times in ten.
Testing it · 15
- VentaProst in Subjects With COVID-19 Requiring Mechanical VentilationCompletedPhase 2Aerogen Pharma LimitedNCT04452669Written as VentaProst (inhaled epoprostenol delivered via a dedicated delivery system)
- Epoprostenol for Injection in Patients With Pulmonary Arterial HypertensionCompletedPhase 3ActelionNCT01470144Written as Epoprostenol
- Epoprostenol for Injection in Pulmonary Arterial HypertensionCompletedPhase 4ActelionNCT01105091Written as ACT-385781A (Actelion Epoprostenol)
- Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)CompletedPhase 2Universitaire Ziekenhuizen KU LeuvenNCT02251041Written as Epoprostenol
- PGI2 Versus Nitroglycerine for Management of Pulmonary Hypertension After Valve SurgeriesStatus unknownPhase 1Ain Shams UniversityNCT04594629Written as PGI2
- Study of a New Thermo Stable Formulation of Epoprostenol Sodium to Treat Pulmonary Arterial Hypertension (PAH)CompletedPhase 4GlaxoSmithKlineNCT01462565Written as current marketed FLOLAN (epoprostenol sodium)
- Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD PlacementCompletedPhase 4Stanford UniversityNCT01717209Written as Prostacyclin
- The Effect of Prostaglandin I2 on the Endothelial Cell Function Disorder in Type 2 Diabetes Mellitus PatientsCompletedPhase 4Yonsei UniversityNCT01061060Written as Prostaglandin I2
- Effects of Prostacyclin Infusion on Cerebral Vessels and Metabolism in Patients With Subarachnoid HaemorrhageCompletedPhase 2Rune RasmussenNCT01447095Written as Prostacyclin 1 ng/kg/min
- Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401CompletedPhase 4ActelionNCT01105117Written as ACT-385781A (Actelion Epoprostenol)
- Epoprostenol in Pulmonary EmbolismCompletedPhase 4Free University Medical CenterNCT01014156Written as epoprostenol
- Prostacyclin's Effect on Platelet ResponsivenessCompletedPhase 4Catholic University of the Sacred HeartNCT00890214Written as prostacyclin
- Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2Status unknownNot applicableGlostrup University Hospital, CopenhagenNCT00510172Written as Prostacyclin, PGI2
- PGI2 Induced Headache and Cerebral Haemodynamics in Healthy VolunteersTerminatedPhase 1Danish Headache CenterNCT00291395Written as PGI2
- Phase IV Study of Chronic Infusional Epoprostenol for Severe Primary Pulmonary HypertensionCompletedPhase 4National Center for Research Resources (NCRR)NCT00004754Written as epoprostenol
Given in every arm · 2 — Epoprostenol is usual care beside what is tested
- Nebulized Epoprostenol (FLOLAN) and Phenylephrine on One Lung Ventilation (OLV)CompletedPhase 4University Health Network, TorontoNCT02748265Written as Inhaled Epoprostenol and phenylephrine
- Study on the Effect of Prostacyclin Compared to Placebo in Traumatic Brain InjuryCompletedPhase 1Umeå UniversityNCT01363583Written as epoprostenol versus normal saline
Codes
What other systems call Epoprostenol · ClinicalTrials.gg INT008116
- MeSH (NLM) D011464EpoprostenolConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) DCR9Z582X0EPOPROSTENOLConfirmed FDA, NLM
- RxNorm 8814One source FDA
- NCI Thesaurus C61748EpoprostenolOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D011464 | Epoprostenol | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | DCR9Z582X0 | EPOPROSTENOL | Confirmed FDA, NLM |
| RxNorm | 8814 | — | One source FDA |
| NCI Thesaurus | C61748 | Epoprostenol | One source FDA |
Also registered as epoprostenol sodium (UNII 4K04IQ1OF4 · RxNorm 104463).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.