Reperfusion Injury clinical trials
The registry lists 260 studies for Reperfusion Injury across more than 10 countries. 43 are recruiting or about to start. 143 of them are mainly about Reperfusion Injury (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 3 narrower conditions too, such as Myocardial Reperfusion Injury: 360 studies, 63 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Radboud University Medical Center (17) · Chinese PLA General Hospital (6) · Medical University of Vienna (5) · Hospices Civils de Lyon (3) · Dompé Farmaceutici S.p.A (3) · University of Zurich (3) · Mansoura University (3) · University of Sao Paulo General Hospital (2)
What is being tested here
Drugs under test in Reperfusion Injury studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Morphine | 2 | 0 | 2 |
| Treprostinil | 1 | 1 | 3 |
| Oxygen | 1 | 1 | 2 |
| Ursodeoxycholic Acid | 1 | 0 | 2 |
| Empagliflozin | 1 | 0 | 2 |
| Pegcetacoplan | 1 | 0 | 1 |
| Vitamin B 6 | 1 | 0 | 1 |
| Pyridoxine | 1 | 0 | 1 |
| Furosemide | 1 | 0 | 1 |
| Mannitol | 1 | 0 | 1 |
Drug classes tested here SGLT2 inhibitors 1 open · Inhaled anesthetics 6 · Statins 5 · Calcineurin inhibitors 3 · GLP-1 receptor agonists 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Function in Recipients of DCD Kidneys · Phase 3 · iCoat Medical AB
- Dec 2026Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal Tumors · Jinling Hospital, China
- Dec 2026Effect Inhaled Nitric Oxide in Adult Liver Transplant · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Jan 2027Intravenous Estrogen in Kidney Transplant Study · University of Pennsylvania
- Mar 2027Hydrogen's Feasibility and Safety as a Therapy in ECPR · Boston Children's Hospital
- Apr 2027Safely Quenching Complement in Stroke Survivors · Columbia University
- May 2027Hypothermic Machine Perfusion for Liver Graft Preservation · University of Sao Paulo General Hospital
- Jun 2027Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage · Vanderbilt University Medical Center
- Jun 2027Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction · Nyrada Pty Ltd
- Aug 2027OR6A2 on Monocytes and Cardiovascular Outcomes in Myocardial Ischemia-Reperfusion Injury · Southeast University, China
Who these studies take
Of the 28 Reperfusion Injury studies recruiting now, 16 (57%) set no upper age limit and 7 (25%) stop at 75 or younger. 1 (4%) take children under 18. 1 (4%) are for women only and 0 (0%) for men only; 1 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 26 (93%) | 25 (89%) |
| 30 | 27 (96%) | 26 (93%) |
| 40 | 28 (100%) | 27 (96%) |
| 50 | 28 (100%) | 27 (96%) |
| 65 | 28 (100%) | 27 (96%) |
| 75 | 24 (86%) | 24 (86%) |
| 85 | 19 (68%) | 19 (68%) |
Across all 260 studies, recruiting or not: 40% stop at 75 or younger and 22% at 65; 7% take children; 3% are for women only and 6% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Reperfusion Injury studies take
Of 18 phase 2 interventional studies under Reperfusion Injury, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 26 mo16–45 · 18 studies | — | — |
| Interventional, no phase | 26 mo15–46 · 50 studies | — | 26 mo15–49 · 46 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 260. Browse all 260 → or search them.
- New Biomarkers for Organ Viability Assessment During Hypothermic Machine Perfusion in Liver Transplantation: the Role of Extemporaneous Histological Examination.Not yet recruitingNCT07674394Not applicable1 country
- Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial InfarctionRecruitingNCT07362446Phase 21 country
- Avoiding Recooling After Normothermic Machine Perfusion in Liver TransplantationRecruitingNCT07692490Not applicable1 country
- Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal TumorsRecruitingNCT07672860Phase 21 country
- The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal TransplantationRecruitingNCT07726134Not applicable1 country
- Remote Ischemic Preconditioning for Aute Type A Aortic Dissection SurgeryRecruitingNCT07383909Not applicable1 country
- Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel OcclusionNot yet recruitingNCT077549421 country
- Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI PatientsNot yet recruitingNCT07749014Phase 21 country
- A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)RecruitingNCT07164833Phase 21 country
- Multi-parametric MRI Evaluation of Renal Graft Performance After Living Donor Donation.RecruitingNCT06047106Not applicable1 country
- Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver TransplantationNot yet recruitingNCT07631689Not applicable
- Hypothermic Machine Perfusion for Liver Graft PreservationNot yet recruitingNCT07595627Not applicable1 country
- Safely Quenching Complement in Stroke SurvivorsNot yet recruitingNCT07495722Phase 1
- Light Utilization COX-Inhibitory Device Therapy for Infant Cardiac Arrest (LUTICA Study). The LUCID Device is Used in the Treatment of Ischemic Brain Reperfusion Injury Caused by Cardiac Arrest in Pediatric Patients.Not yet recruitingNCT07556939Not applicable1 country
- OSA as a Remote Ischemic Preconditioning in Vascular SurgeryRecruitingNCT046305351 country
- Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney TransplantationRecruitingNCT04005469Phase 1/21 country
- Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)Not yet recruitingNCT07526649Not applicable1 country
- Deceased Donor Kidney Storage at 10 Celsius Versus Conventional StorageRecruitingNCT07385651Not applicable1 country
- DIEP Flap Breast Reconstruction: Perioperative Biomarkers and OutcomesRecruitingNCT072633471 country
- Kidney Protective JacketRecruitingNCT07348458Not applicable1 country
- Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusionNot yet recruitingNCT06369350Early Phase 1
- Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion InjuryRecruitingNCT06947135Not applicable1 country
- Intracoronary Hypothermia as a Prevention of Reperfusion Injury in Myocardial Infarction.RecruitingNCT06567249Not applicable1 country
- Effect Inhaled Nitric Oxide in Adult Liver TransplantNot yet recruitingNCT07125443Not applicable
- OR6A2 on Monocytes and Cardiovascular Outcomes in Myocardial Ischemia-Reperfusion InjuryRecruitingNCT071004571 country
- Stellate Ganglion Morphine Infiltration on Myocardial I/R InjuryRecruitingNCT07023679Not applicable1 country
- Hydrogen's Feasibility and Safety as a Therapy in ECPRRecruitingNCT05574296Phase 11 country
- Reperfusion Injury After Endovascular Stroke TreatmentRecruitingNCT052732161 country
- Remote Ischaemic Conditioning in STEMI Patients in AFRICARecruitingNCT04813159Not applicable6 countries
- A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Function in Recipients of DCD KidneysNot yet recruitingNCT06582485Phase 2/3
- Hypertonic Lactate After Cardiac ArrestRecruitingNCT05004610Phase 21 country
- Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion InjuryNot yet recruitingNCT06825143Early Phase 11 country
- Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage.Not yet recruitingNCT06523920Not applicable
- Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass GraftingRecruitingNCT06141525Not applicable1 country
- Intermittent Versus Continuous Surface O2 During HMP of DCD KidneysRecruitingNCT05430620Phase 31 country
- Liver Ischemia-reperfusion Injury and Clinical Data AnalysisRecruitingNCT060803081 country
- Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion InjuryRecruitingNCT055852551 country
- Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver TransplantationRecruitingNCT06236568Not applicable1 country
- Upfront Premedication For Reduction of Microvascular Obstruction and No-reflow in Treating ST-segment Elevation Myocardial InfarctionNot yet recruitingNCT05393557Not applicable
- HOPE With Cytokine Filtration in Liver Transplantation (Cyto-HOPE)RecruitingNCT04203004Not applicable1 country
- Study of Cerebral Venous System in Acute Ischemic Stroke Patients Receiving Reperfusion TherapyRecruitingNCT038382891 country
- Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent ClaudicationRecruitingNCT051113791 country
- Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ TransplantationNot yet recruitingNCT03946852Not applicable
- NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury TrialCompletedNCT04750616Phase 21 country
- Nitric Oxide-mediated Cardioprotection During Cardiac Surgery With Cardiopulmonary BypassCompletedNCT03500783Phase 1/2
- Cardio-protective Effect of Metformin in Patients Undergoing PCICompletedNCT05708053Phase 31 country
- Early Intracoronary N-Acetylcysteine During Primary PCI in STEMI: A Pilot Randomized Trial of Reperfusion Injury Biomarkers and Functional RecoveryCompletedNCT06850831Phase 21 country
- Auricular Vagus Stimulation and STEMICompletedNCT05992259Not applicable1 country
- Goal-directed CPR Using Cerebral OximetryCompletedNCT04924985Not applicable1 country
- Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.CompletedNCT068957981 country