Drug

Efavirenz clinical trials

Also written Sustiva, EFV, Stocrin and BMS-561525.

studies test it: 147
open now: 3
in phase 3: 34
first study started: 1997

Counted the way a researcher would: Efavirenz with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.

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How each study uses efavirenz is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

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Approvals

The first approval found in each region, with its record

United States: 17 Sept 1998 · SUSTIVA · NDA 020972 (FDA, Drugs@FDA)
European Union: 28 May 1999 · Sustiva · EMEA/H/C/000249 (EMA; now withdrawn)

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Efavirenz: 90
Efavirenz 600mg: 7
Efavirenz (EFV): 7
Sustiva (efavirenz): 4
Atripla: 3

Brand

Sustiva: 23
Stocrin: 5

Development codes

BMS-561525: 2
MK0831: 1

Other names

EFV: 11

In one entry with another drug

Given together, or one or the other

tenofovir + emtricitabine + efavirenz: 2

Studies by the year they started

129 studies that test it; most in 2006 (12)

Studies that test efavirenz, by start year
Year	Studies
1997	2
1999	10
2000	3
2001	7
2002	3
2003	2
2004	10
2005	6
2006	12
2007	10
2008	12
2009	6
2010	5
2011	7
2012	5
2013	4
2014	5
2015	3
2016	2
2017	2
2018	5
2019	1
2020	3
2022	1
2023	1
2025	1
2026	1

By phase

A phase 1/2 study counts in both.

Early Phase 1: 1
Phase 1: 29
Phase 2: 30
Phase 3: 34
Phase 4: 40
No phase: 16

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

HIV Infections: 89
Acquired Immunodeficiency Syndrome: 9
Tuberculosis: 3
Hepatitis C: 2
Pancreatic Neoplasms: 1
Alzheimer Disease: 1
Prostatic Neoplasms: 1
Lymphoma, Non-Hodgkin: 1
Hyperlipidemias: 1
Meningitis, Cryptococcal: 1
Malaria: 1
Cardiovascular Diseases: 1

Who runs them

Industry 44 · Other 103

National Institute of Allergy and Infectious Diseases (NIAID) (19) · Bristol-Myers Squibb (9) · Kirby Institute (5) · Gilead Sciences (5) · French National Agency for Research on AIDS and Viral Hepatitis (4) · Shanghai Public Health Clinical Center (4) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (4) · St Stephens Aids Trust (4)

Often tested with

Tested in the same studies.

Lamivudine (32) · Tenofovir (21) · Ritonavir (19) · Zidovudine (17) · Abacavir (15) · Emtricitabine (14) · Didanosine (13) · Lopinavir-ritonavir drug combination (13)

Related medicines

As reviewed, each with the page that says it.

One of Reverse transcriptase inhibitors source

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Reaching primary completion within a year · 2

Studies that test efavirenz.

Dec 2026Reverse Triple Negative Immune Resistant Breast CancerPhase 2 · Fudan University
Nov 2027The T Cell Activator of Cell Killing ("TACK") IT ON" STUDYNot applicable · University of Toronto

Studies

Open first, then newest update. How each study uses efavirenz is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 147

See all 147 studies that test efavirenz →

Given beside what is tested · 32 — efavirenz is usual care or a partner of the new treatment

Showing 20 of 32.

As the comparator · 40 — what is tested is compared with efavirenz

Showing 20 of 40.

Codes

What other systems call efavirenz · ClinicalTrials.gg INT003893

MeSH (NLM) C098320efavirenzConfirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA) JE6H2O27P8EFAVIRENZConfirmed FDA, NLM, Wikidata
RxNorm 195085Confirmed FDA, Wikidata
Wikidata Q422645efavirenzConfirmed FDA, NLM, Wikidata
NCI Thesaurus C29027EfavirenzOne source FDA
DrugBank DB00625One source Wikidata

System	Code	Name there	Checked by
MeSH (NLM)	C098320	efavirenz	Confirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA)	JE6H2O27P8	EFAVIRENZ	Confirmed FDA, NLM, Wikidata
RxNorm	195085	—	Confirmed FDA, Wikidata
Wikidata	Q422645	efavirenz	Confirmed FDA, NLM, Wikidata
NCI Thesaurus	C29027	Efavirenz	One source FDA
DrugBank	DB00625	—	One source Wikidata

Also registered as efavirenz, (r)- (UNII CEE19E5D5F).

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.