Drug
Lamivudine clinical trials
Also written Epivir, 3TC and Zeffix.
- studies test it
- 230
- open now
- 13
- in phase 3
- 75
- first study started
- 1995
Keep track of what changes. Save the Lamivudine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
- 3TC
- 20
Combined with it in one product
Studies by the year they started
189 studies that test it; most in 2015 (15)
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1996 | 1 |
| 1999 | 10 |
| 2000 | 5 |
| 2001 | 4 |
| 2002 | 8 |
| 2003 | 6 |
| 2004 | 10 |
| 2005 | 12 |
| 2006 | 8 |
| 2007 | 9 |
| 2008 | 7 |
| 2009 | 6 |
| 2010 | 4 |
| 2011 | 8 |
| 2012 | 4 |
| 2013 | 6 |
| 2014 | 7 |
| 2015 | 15 |
| 2016 | 6 |
| 2017 | 5 |
| 2018 | 5 |
| 2019 | 7 |
| 2020 | 4 |
| 2021 | 5 |
| 2022 | 4 |
| 2023 | 4 |
| 2024 | 8 |
| 2025 | 6 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 3
- Phase 1
- 22
- Phase 2
- 51
- Phase 3
- 75
- Phase 4
- 67
- No phase
- 22
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 75 · Other 155
National Institute of Allergy and Infectious Diseases (NIAID) (33) · ViiV Healthcare (18) · Glaxo Wellcome (12) · Merck Sharp & Dohme LLC (9) · Bristol-Myers Squibb (7) · ANRS, Emerging Infectious Diseases (6) · GlaxoSmithKline (5) · Fundación Huésped (4)
Often tested with
Tested in the same studies.
Zidovudine (69) · Dolutegravir (34) · Abacavir (32) · Efavirenz (32) · Tenofovir (27) · Nevirapine (23) · Stavudine (23) · Ritonavir (19)
Studies
Open first, then newest update. How each study uses Lamivudine is read from its arms, and is right about nine times in ten.
Testing it · 230
- Efficacy and Safety of Doravirine in the Rapid InitiationRecruitingPhase 4Fundación HuéspedNCT07357584Written as Doravirine / lamivudine/ Tenofovir Disoproxil Oral Tablet
- An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in AfricaNot yet recruitingPhase 3University College, LondonNCT07792096Written as Lamivudine (3TC)
- A Continued Access Study for Participants Transitioning From ViiV Healthcare-sponsored or ViiV Healthcare-collaborative Parent Studies for HIV TreatmentRecruitingPhase 3ViiV HealthcareNCT07393659Written as Dolutegravir (DTG)/ Lamivudine (3TC)
- DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 InfectionRecruitingPhase 3ANRS, Emerging Infectious DiseasesNCT06203132Written as Doravirine + tenofovir DF + lamivudine
- STARLITE for Unresectable High-Grade GliomasRecruitingPhase 1University of MiamiNCT06428045Written as Lamivudine
- Lamivudine as a Novel Clinical Effort for Rett SyndromeEnrolling by invitationPhase 2Maria Denise Fernandes Carvalho de AndradeNCT07640503Written as Lamivudine
- Comparative Trial Between Ainuovirine(ANV)/Lamivudine(3TC)/Tenofovir(TDF) and Efavirenz(EFV)/Lamivudine/Tenofovir RegimensNot yet recruitingPhase 4Shanghai Public Health Clinical CenterNCT07631897Written as Ainuovirine, Lamivudine and Tenofovir Disoproxil Fumarate Tablets
- Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung CancerRecruitingPhase 2Roswell Park Cancer InstituteNCT04696575Written as Lamivudine
- Efficacy, Safety, and ToLerability of Switching to A Two-Drug Regimen With DTG/3TC Compared to Maintaining A Three-Drug REgimen With BIC/FTC/TAF or DTG/3TC/ABC in ViroLogically SupprEssed PeopLe Living With HIV After 24 and 48 Weeks of Follow-UpRecruitingPhase 4José Antonio Mata MarínNCT07138144Written as dual therapy
- Safety, Tolerability and Effectiveness of DTG/3TC vs BIC/TAF/FTC in PWH Without Antiretroviral ExperienceRecruitingPhase 4Instituto Mexicano del Seguro SocialNCT07031063Written as DTG/3TC
- Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Versus Darunavir/Cobicistat Plus Tenofovir/Emtricitabine in Virologically Suppressed HIV-1-positive Individuals in MexicoRecruitingPhase 4José Antonio Mata MarínNCT06907056Written as dual therapy
- Change in Body Weight and BMI in PWH with DOR/3TC/TDF Compared with INSTIRecruitingPhase 4Instituto Mexicano del Seguro SocialNCT06602622Written as Doravirine + tenofovir DF + lamivudine
- Antiviral Therapy in Infants With HBV InfectionNot yet recruitingPhase 4Beijing 302 HospitalNCT06503796Written as Lamivudine
- ANRS 12372 MODERATO StudyCompletedPhase 3ANRS, Emerging Infectious DiseasesNCT04022967Written as Lamivudine
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral TherapyActive, not recruitingPhase 3ViiV HealthcareNCT05979311Written as Lamivudine
- Lamivudine for Solid TumorsActive, not recruitingPhase 1/2Thomas MarronNCT06494579Written as Lamivudine
- A Study of Exercise and Pharmacologic Intervention on Systemic InflammationActive, not recruitingPhase 1Icahn School of Medicine at Mount SinaiNCT07058974Written as lamivudine
- A Study to Evaluate Efficacy, Safety and Tolerability in Antiretroviral Therapy (ART)-Experienced Participants of at Least 50 Years of Age Living With Human Immunodeficiency Virus (HIV) With Virologic Suppression Who Switch to DTG/3TC FDC From BIC/FTC/TAFCompletedPhase 3ViiV HealthcareNCT05911360Written as DTG/3TC
- A Study to Evaluate the Efficacy, Safety, Participant Choice and Preference of an Oral Once-daily Regimen or a Long-acting Injectable Regimen Every Two Months for Treatment of Human Immunodeficiency Virus (HIV-1) in Adults Who Have Not Previously Taken Antiretroviral TherapyCompletedPhase 3ViiV HealthcareNCT05917509Written as DTG/3TC
- B/F/TAF to DTG/3TC Switch StudyActive, not recruitingPhase 3University of NairobiNCT06444620Written as DTG/3TC
See all 230 studies that test Lamivudine →
Given in every arm · 27 — Lamivudine is usual care beside what is tested
- Clinical Trial to Evaluate the Efficacy, Pharmacokinetics (PK) Interactions and Safety of Dolutegravir Plus 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in HIV-1-Infected Solid Organ Transplant PatientsCompletedPhase 4Fundacion Clinic per a la Recerca BiomédicaNCT03360682Written as Lamivudine 300 MG
- A Study to Determine the Safety and Efficacy of Rilpivirine in Treatment-naive Indian Participants With Human Immunodeficiency Virus Type 1 (HIV-1) InfectionTerminatedPhase 3Janssen Research & Development, LLCNCT03563742Written as Tenofovir Disoproxil Fumarate (TDF)/Lamivudine (3TC)
- A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 YearsCompletedPhase 2Janssen Sciences Ireland UCNCT00799864Written as Lamivudine
- Pharmacokinetic and Safety Study of Raltegravir and Atazanavir in a Once Daily Dose Regimen in HIV-1 Infected PatientsCompletedPhase 2Radboud University Medical CenterNCT00943540Written as lamivudine (or emtricitabine)
- Nucleosides And Darunavir/Dolutegravir In AfricaStatus unknownPhase 3Makerere UniversityNCT03988452Written as Lamivudine
- Dosing of Tenofovir and Efavirenz in Antiretroviral TherapyCompletedPhase 4Shanghai Public Health Clinical CenterNCT02945163Written as Lamivudine
- Dolutegravir Antiretroviral Strategy to Promote Improvement and Reduce Drug ExposureCompletedPhase 3Babafemi TaiwoNCT02263326Written as lamivudine
- Clinical Study of Antiviral and Aspirin Treatment in Liver Cancer After Radical SurgeryStatus unknownPhase 3Fudan UniversityNCT01936233Written as Lamivudine
- Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant WomenCompletedPhase 3University of California, San FranciscoNCT00993031Written as Lamivudine
- A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy RegimenCompletedPhase 2Michael HoelscherNCT01714414Written as 3TC
- SSAT063- Pharmacokinetics of Efavirenz 400 mg Once Daily During Pregnancy in HIV-1 Infected WomenCompletedPhase 1St Stephens Aids TrustNCT02499874Written as tenofovir/lamivudine
- Pharmacokinetics of Efavirenz in the Presence of Rifampicin and IsoniazidStatus unknownPhase 1St Stephens Aids TrustNCT02832778Written as tenofovir/lamivudine
- Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIVCompletedPhase 2International Maternal Pediatric Adolescent AIDS Clinical Trials GroupNCT00307151Written as Lamivudine
- Lamivudine and Therapeutic Vaccine Evaluation in Senegalese Patients With Chronic Hepatitis B Infection (ANRS 12100 HEPADAK-2)TerminatedPhase 3French National Agency for Research on AIDS and Viral HepatitisNCT00120796Written as Lamivudine
- Safety, Efficacy and Dose-response Study of BMS-986001 in Subjects With HIV-1 Infection Who Are Treatment-naiveTerminatedPhase 2Bristol-Myers SquibbNCT01489046Written as Lamivudine
- Abacavir and Lamivudine PK in ChildrenCompletedPhase 2/3The HIV Netherlands Australia Thailand Research CollaborationNCT01656122Written as 3TC
- A Study to Evaluate Efficacy and Safety of Peginterferon Alfa-2a (Pegasys) and Adeforvir Dipivoxil (ADV) in Participants With Lamivudine-Resistant Hepatitis B e Antigen (HBeAg)-Positive Chronic Hepatitis BCompletedPhase 4Hoffmann-La RocheNCT02598063Written as Lamivudine
- Atazanavir and Lamivudine for Treatment SimplificationCompletedPhase 4Catholic University of the Sacred HeartNCT00885482Written as Lamiduvine (Epivir)
- Part A: Drug Interaction Study of Sofosbuvir and Antiretroviral Therapy (ART) Combinations in HIV and Hepatitis C Virus (HCV) Co-infected Patients. Part B: Efficacy and Safety of Sofosbuvir for 12 Weeks in HIV/HCV Co-infected Patients.CompletedPhase 1/2Gilead SciencesNCT01565889Written as ZDV/3TC
- Anti-HIV Treatment Interruptions in HIV Infected Adults in South AfricaCompletedNot applicableThe Wistar InstituteNCT00100646Written as Lamivudine
Showing 20 of 27.
As the comparator · 39 — what is tested is compared with Lamivudine
- A Phase 2b Study Evaluating VH4011499 Capsid Inhibitor Long-Acting Injectable Plus Cabotegravir in Treatment Naïve Adults (CINERGY)Not yet recruitingPhase 2ViiV HealthcareNCT07816250Written as DTG/3TC
- Dolutegravir/Lamivudine Dual Therapy for ART-naïve People With HIV and TB Receiving Rifampin-based TB TreatmentRecruitingPhase 3Johns Hopkins UniversityNCT06497465Written as Dolutegravir plus Tenofovir disoproxil fumarate (TDF)/ lamivudine (3TC)
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)RecruitingPhase 2ViiV HealthcareNCT07202546Written as Dolutegravir / Lamivudine (DTG/3TC)
- Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With Darunavir/Cobicistat Plus Tenofovir Alafenamide/Emtricitabine in Virologically Suppressed People Living With HIV at 24 and 48 Weeks of Follow-upRecruitingPhase 4Instituto Mexicano del Seguro SocialNCT07678268Written as Dual therapy: darunavir/cobicistat + lamivudine
- Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV NaiveWithdrawnPhase 4Juan A. ArnaizNCT02470650Written as Lamivudine
- A Phase IV Study to Assess the Impact of the Change of Antiretroviral Treatment From Dual Therapy to Triple Therapy on Inflammation in Patients With HIV InfectionCompletedPhase 4Fundacion SEIMC-GESIDANCT04076423Written as Dual Therapy
- A Clinical Trial of GSK3640254 + Dolutegravir (DTG) in Human Immunodeficiency Virus-1 Infected Treatment-naive AdultsTerminatedPhase 2ViiV HealthcareNCT04900038Written as Lamivudine capsules
- Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in Human Immunodeficiency Virus (HIV)-1 Infected, Treatment-naive ParticipantsCompletedPhase 2Alexion Pharmaceuticals, Inc.NCT00350272Written as Lamivudine
- Study of Once Daily Elvucitabine Versus Lamivudine in Participants With a Documented M184V MutationCompletedPhase 1/2Alexion Pharmaceuticals, Inc.NCT00312039Written as Lamivudine
- Test Albuvirtide in Experienced PatientsCompletedPhase 3Frontier Biotechnologies Inc.NCT02369965Written as lamivudine
- Phase III Clinical Study of Azvudine in Hiv-infected Treatment Naive PatientsStatus unknownPhase 3HeNan Sincere Biotech Co., LtdNCT04303598Written as 3TC
- Switching From a Tenofovir Disoproxil Fumarate (TDF) Containing Regimen to Elvitegravir/Cobicistat/Emtricitabine/ Tenofovir Alafenamide (E/C/F/TAF) Fixed-Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Infected Adults Aged ≥ 60 YearsCompletedPhase 3Gilead SciencesNCT02616783Written as 3TC
- Neurological Monitoring in Patients Switching From Dolutegravir Based Regimen to Bictegravir Based RegimenStatus unknownPhase 3Azienda Ospedaliera Universitaria SeneseNCT04155554Written as Dolutegravir/lamivudine/abacavir
- Lamivudine and Adefovir Dipivoxil Fixed Dose CombinationCompletedPhase 1GlaxoSmithKlineNCT01353742Written as Lamivudine
- Comparison of Prophylactic Antiviral Efficacy in Patients Undergoing Chemotherapy: Entecavir Versus LamivudineCompletedPhase 3Seoul National University HospitalNCT01580202Written as Lamivudine
- TDF VS LAM + ADV in LAM + ADV Treated LAM-resistant CHB Patients With Undetectable Hepatitis B Virus DNACompletedPhase 4Keimyung University Dongsan Medical CenterNCT01732367Written as Lamivudine plus adefovir
- Switch to Tenofovir Versus Continue Lamivudine/Adefovir Treatment in Lamivudine-resistance Chronic Hepatitis B PatientsStatus unknownPhase 4Taipei Veterans General Hospital, TaiwanNCT01491295Written as Lamivudine plus adefovir
- Compare Continuing Lamivudine Plus Adefovir or Adefovir Versus Switching to Entecavir Plus Adefovir in Patients With LAM-resistant Chronic Hepatitis BStatus unknownPhase 4Asan Medical CenterNCT02482272Written as Lamivudine
- Entecavir Plus Adefovir in Lamivudine-Resistant PatientsWithdrawnPhase 4Bristol-Myers SquibbNCT00986778Written as Lamivudine
- Peripheral Body Fat Distribution After Switching Zidovudine and Lamivudine to TruvadaCompletedPhase 4Gilead SciencesNCT00324649Written as Zidovudine/lamivudine
Showing 20 of 39.
Codes
What other systems call Lamivudine · ClinicalTrials.gg INT008668
- MeSH (NLM) D019259LamivudineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 2T8Q726O95LAMIVUDINEConfirmed FDA, NLM, Wikidata
- RxNorm 68244Confirmed FDA, Wikidata
- Wikidata Q422631lamivudineConfirmed FDA, NLM, Wikidata
- Wikidata Q27266574(+/-)-trans-lamivudineConfirmed NLM, Wikidata
- NCI Thesaurus C1471LamivudineOne source FDA
- DrugBank DB00709One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D019259 | Lamivudine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 2T8Q726O95 | LAMIVUDINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 68244 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422631 | lamivudine | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q27266574 | (+/-)-trans-lamivudine | Confirmed NLM, Wikidata |
| NCI Thesaurus | C1471 | Lamivudine | One source FDA |
| DrugBank | DB00709 | — | One source Wikidata |
Also registered as lamivudine, cis(+)- (UNII H6S9D88T3D) and lamivudine, trans(+/-)- (UNII 77ANF82R6X).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.