BiologicalDrug
Dactinomycin clinical trials
Also written Cosmegen and Actinomycin D.
- studies test it
- 28
- open now
- 5
- in phase 3
- 12
- first study started
- 1995
Keep track of what changes. Save the Dactinomycin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
28 studies that test it; most in 2004 (4)
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1996 | 1 |
| 1999 | 3 |
| 2003 | 2 |
| 2004 | 4 |
| 2006 | 2 |
| 2007 | 1 |
| 2009 | 3 |
| 2011 | 1 |
| 2012 | 2 |
| 2014 | 1 |
| 2020 | 2 |
| 2021 | 1 |
| 2024 | 1 |
| 2025 | 2 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 3
- Phase 2
- 11
- Phase 3
- 12
- Phase 4
- 1
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 0 · Other 28
Children's Oncology Group (10) · Memorial Sloan Kettering Cancer Center (2) · Gynecologic Oncology Group (2) · Japan Rhabdomyosarcoma Study Group (2) · Children's Hospitals and Clinics of Minnesota (1) · xiang yang (1) · GOG Foundation (1) · Dana-Farber Cancer Institute (1)
Often tested with
Tested in the same studies.
Vincristine (18) · Cyclophosphamide (14) · Doxorubicin (11) · Etoposide (8) · Ifosfamide (5) · Irinotecan (5) · Methotrexate (4) · Filgrastim (4)
Studies
Open first, then newest update. How each study uses Dactinomycin is read from its arms, and is right about nine times in ten.
Testing it · 28
- Metastatic Ewing's Trial Testing Schedule Enhancement to Improve OutcomesRecruitingPhase 1H. Lee Moffitt Cancer Center and Research InstituteNCT07194044Written as Actinomycin
- A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)RecruitingPhase 3Children's Oncology GroupNCT06401330Written as Dactinomycin
- Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary BlastomaRecruitingPhase 3Children's Oncology GroupNCT06647953Written as Dactinomycin
- Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7RecruitingPhase 2Peking Union Medical College HospitalNCT06020755Written as Actinomycin-D
- FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcomaRecruitingPhase 1/2University of BirminghamNCT04625907Written as Actinomycin D
- International Pleuropulmonary Blastoma (PPB) Treatment and Biology RegistryActive, not recruitingNot applicableChildren's Hospitals and Clinics of MinnesotaNCT01464606Written as Dactinomycin
- A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk RhabdomyosarcomaActive, not recruitingPhase 3Children's Oncology GroupNCT04994132Written as Dactinomycin
- Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' TumorCompletedPhase 3Children's Oncology GroupNCT00379340Written as Dactinomycin
- Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' TumorCompletedPhase 3Children's Oncology GroupNCT00352534Written as Dactinomycin
- Combination Chemotherapy and Surgery in Treating Young Patients With Wilms TumorCompletedPhase 3Children's Oncology GroupNCT00945009Written as Dactinomycin
- Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic NeoplasiaActive, not recruitingNot applicablexiang yangNCT04562558Written as Dactinomycin
- Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic NeoplasiaCompletedPhase 3GOG FoundationNCT01535053Written as Dactinomycin
- Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney CancerCompletedPhase 3Children's Oncology GroupNCT00002611Written as dactinomycin
- Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic NeoplasiaStatus unknownPhase 3Ding MaNCT01823315Written as Act-d
- Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus TumorsTerminatedPhase 3Tufts Medical CenterNCT01014767Written as Dactinomycin
- Addition of Ipilimumab (MDX-010) To Isolated Limb Infusion (ILI) With Standard Melphalan and Dactinomycin In The Treatment of Advanced Unresectable Melanoma of The ExtremityCompletedPhase 2Memorial Sloan Kettering Cancer CenterNCT01323517Written as Ipilimumab, Melphalan and Dactinomycin
- Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic NeoplasiaCompletedPhase 3Gynecologic Oncology GroupNCT00003702Written as Dactinomycin
- Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney TumorsCompletedPhase 2Children's Oncology GroupNCT00335556Written as Dactinomycin
- Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RTCompletedPhase 2Dana-Farber Cancer InstituteNCT00084838Written as Dactinomycin
- Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood FibrosarcomaTerminatedPhase 2Children's Oncology GroupNCT00072280Written as dactinomycin
See all 28 studies that test Dactinomycin →
Given in every arm · 15 — Dactinomycin is usual care beside what is tested
- Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative RhabdomyosarcomaRecruitingPhase 3Children's Oncology GroupNCT05304585Written as Dactinomycin
- A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)RecruitingPhase 3Children's Oncology GroupNCT07466316Written as Dactinomycin
- Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk DiseaseRecruitingPhase 2St. Jude Children's Research HospitalNCT06023641Written as Dactinomycin
- Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6RecruitingNot applicablePeking Union Medical College HospitalNCT06028672Written as Actinomycin-D
- Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk RhabdomyosarcomaActive, not recruitingPhase 3National Cancer Institute (NCI)NCT02567435Written as Dactinomycin
- Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified ChemotherapyActive, not recruitingPhase 2St. Jude Children's Research HospitalNCT01871766Written as Dactinomycin
- Evolutionary Therapy for RhabdomyosarcomaActive, not recruitingPhase 2H. Lee Moffitt Cancer Center and Research InstituteNCT04388839Written as Actinomycin D
- GAMEC-II, Risk-adapted Protocol for Relapsed Germ Cell Tumours (GCT)CompletedPhase 2Queen Mary University of LondonNCT06309732Written as Dactinomycin
- Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed RhabdomyosarcomaCompletedPhase 3Children's Oncology GroupNCT00354835Written as Dactinomycin
- Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk RhabdomyosarcomaCompletedPhase 3Children's Oncology GroupNCT00075582Written as dactinomycin
- High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or EctomesenchymomaCompletedPhase 3Children's Oncology GroupNCT00354744Written as dactinomycin
- Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic RhabdomyosarcomaCompletedPhase 2National Cancer Institute (NCI)NCT01055314Written as Dactinomycin
- Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or LymphomaCompletedPhase 3Memorial Sloan Kettering Cancer CenterNCT00002766Written as dactinomycin
- Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's SarcomaStatus unknownPhase 3University of LeicesterNCT00020566Written as dactinomycin
- Combination Chemotherapy in Treating Patients With Previously Untreated RhabdomyosarcomaCompletedPhase 3Children's Oncology GroupNCT00003958Written as dactinomycin
As the comparator · 1 — what is tested is compared with Dactinomycin
Codes
What other systems call Dactinomycin · ClinicalTrials.gg INT007296
- MeSH (NLM) D003609DactinomycinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 1CC1JFE158DACTINOMYCINConfirmed FDA, NLM, Wikidata
- RxNorm 3100Confirmed FDA, Wikidata
- Wikidata Q186127dactinomycinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C412DactinomycinOne source FDA
- DrugBank DB00970One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D003609 | Dactinomycin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 1CC1JFE158 | DACTINOMYCIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 3100 | — | Confirmed FDA, Wikidata |
| Wikidata | Q186127 | dactinomycin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C412 | Dactinomycin | One source FDA |
| DrugBank | DB00970 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.