Gestational Trophoblastic Disease clinical trials
The registry lists 57 studies for Gestational Trophoblastic Disease across more than 10 countries. 16 are recruiting or about to start. 32 of them are mainly about Gestational Trophoblastic Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Who runs them
Fred Hutchinson Cancer Center (5) · Women's Hospital School Of Medicine Zhejiang University (5) · Gynecologic Oncology Group (4) · Peking Union Medical College Hospital (4) · Hospices Civils de Lyon (4) · Vanderbilt-Ingram Cancer Center (2) · Assiut University (2) · Ohio State University Comprehensive Cancer Center (2)
What is being tested here
Drugs under test in Gestational Trophoblastic Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Toripalimab | 2 | 0 | 2 |
| Dactinomycin | 1 | 1 | 4 |
| Camrelizumab | 1 | 0 | 2 |
| Pembrolizumab | 1 | 0 | 2 |
| Paclitaxel | 1 | 1 | 1 |
| Cisplatin | 1 | 1 | 1 |
| Methotrexate | 0 | 1 | 2 |
| Alemtuzumab | 0 | 0 | 2 |
| Domvanalimab | 0 | 0 | 1 |
| Zimberelimab | 0 | 0 | 1 |
Drug classes tested here Immune checkpoint inhibitors 4 open · Antimetabolites 3 · Corticosteroids 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia · Peking Union Medical College Hospital
- Dec 2026Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic Neoplasia · Women's Hospital School Of Medicine Zhejiang University
- Jan 2027Uterine Artery Doppler Flow Velocimetry Parameters for Predicting the Occurrence of Persistent Gestational Trophoblastic Neoplasia After Evacuation of Complete Hydatiform Mole · Minia University
Who these studies take
Of the 14 Gestational Trophoblastic Disease studies recruiting now, 6 (43%) set no upper age limit and 8 (57%) stop at 75 or younger. 6 (43%) take children under 18. 14 (100%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (29%) | 0 (0%) |
| 18 | 14 (100%) | 0 (0%) |
| 30 | 14 (100%) | 0 (0%) |
| 40 | 14 (100%) | 0 (0%) |
| 50 | 14 (100%) | 0 (0%) |
| 65 | 7 (50%) | 0 (0%) |
| 75 | 7 (50%) | 0 (0%) |
| 85 | 6 (43%) | 0 (0%) |
Across all 57 studies, recruiting or not: 39% stop at 75 or younger and 28% at 65; 30% take children; 61% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 57. Browse all 57 → or search them.
- Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic NeoplasiaRecruitingNCT05139095Phase 21 country
- Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic NeoplasiaRecruitingNCT03703271Phase 21 country
- Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung NoduleRecruitingNCT03785574Not applicable1 country
- Uterine Artery Doppler Flow Velocimetry Parameters for Predicting the Occurrence of Persistent Gestational Trophoblastic Neoplasia After Evacuation of Complete Hydatiform MoleNot yet recruitingNCT07333326
- Clinicopathological Features , Outcomes and Prognostic Factors of High Risk Patients of Gestational Trophoblastic NeoplasiaNot yet recruitingNCT06900699
- The Psychological Impact of GTN on Women Who Have Completed Chemotherapy TreatmentRecruitingNCT061696441 country
- Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6RecruitingNCT06028672Not applicable1 country
- Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7RecruitingNCT06020755Phase 21 country
- Clinical Specialty Queue For Gestational Trophoblastic NeoplasiaRecruitingNCT066812591 country
- A Feasibility Window Study of Pembrolizumab Prior to Second Evacuation for Post-molar Gestational Trophoblastic NeoplasiaRecruitingNCT05635344Phase 21 country
- Gestional Trophoblastic Neoplasia Ultrasound Assessment: Titanium StudyRecruitingNCT062849801 country
- Avelumab and Methotrexate in in Low-risk Gestational Trophoblastic Neoplasias as First Line TreatmentRecruitingNCT04396223Phase 1/21 country
- Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic TumorRecruitingNCT02639650Phase 31 country
- Study of PD-1 Antibody and Bevacizumab in the Treatment of High-risk GTN After Combined ChemotherapyRecruitingNCT04812002Phase 21 country
- Second Uterine Evacuation for Low-risk Gestational Trophoblastic NeoplasiaRecruitingNCT04756713Phase 31 country
- The French National Reference Centre of GTDRecruitingNCT028928771 country
- ASk Questions in GYnecologic Oncology (ASQ-GYO)CompletedNCT06339827Not applicable1 country
- IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE CancersActive, not recruitingNCT06790706Phase 21 country
- Nivolumab and Ipilimumab in Treating Patients With Rare TumorsActive, not recruitingNCT02834013Phase 22 countries
- Avelumab in Chemo-resistant Gestational Trophoblastic NeoplasiasCompletedNCT03135769Phase 21 country
- Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic NeoplasiaActive, not recruitingNCT04562558Not applicable1 country
- The Registry of Oncology Outcomes Associated with Testing and TreatmentCompletedNCT040284791 country
- Dostarlimab in Chemoresistant Gestational Trophoblastic NeoplasiaWithdrawnNCT05405192Phase 21 country
- Letrozole as a Prophylaxis From GTN for Complete Mole PatientsStatus unknownNCT05203562Phase 2/31 country
- Camrelizumab Combined With Apatinib for Recurrent Resistant GTNCompletedNCT04047017Phase 21 country
- Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural EffusionsCompletedNCT00066404Phase 11 country
- Phase 2 Trial for Chemo-Resistant Gestational Trophoblastic Neoplasias With Pembrolizumab (CR-GTP)Status unknownNCT04303884Phase 21 country
- Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic NeoplasiaStatus unknownNCT01823315Phase 31 country
- Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic CancerCompletedNCT02096783Not applicable1 country
- T Cells in Predicting Acute Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell TransplantTerminatedNCT006517161 country
- Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)TerminatedNCT02664961Phase 21 country
- Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma (GTN) Patients With Score of 5-6Status unknownNCT03885388Phase 2/31 country
- Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast CancerCompletedNCT01764802Phase 21 country
- A Global Assessment of Medical, Emotional and Reproductive Concerns in Gestational Trophoblastic Disease SurvivorsCompletedNCT007068751 country
- Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar PregnancyTerminatedNCT00096187Phase 21 country
- Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic NeoplasiaStatus unknownNCT03280979Phase 2/3
- Blood Samples From Patients on a Clinical Trial to CINV During HSCTTerminatedNCT009000681 country
- Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell TransplantTerminatedNCT00324324Phase 31 country
- Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic NeoplasmsStatus unknownNCT02606539Phase 2/31 country
- Collecting Tumor Samples From Patients With Gynecological TumorsCompletedNCT008974421 country
- Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell TransplantCompletedNCT00293384Not applicable1 country
- Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast CancerCompletedNCT01764789Not applicable1 country
- Detection of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic DiseaseStatus unknownNCT001667901 country
- Interleukin-12 in Treating Patients With Hematologic Cancers or Solid TumorsCompletedNCT00003107Phase 11 country
- Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid TumorsCompletedNCT00003597Phase 12 countries
- Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for CancerCompletedNCT00058071Phase 31 country
- Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic NeoplasiaCompletedNCT00003688Phase 22 countries
- Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With CancerCompletedNCT00003408Phase 21 country
- Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell TransplantCompletedNCT009004061 country
- Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell TransplantationCompletedNCT00064311Phase 1/21 country