Carcinoma, Renal Cell clinical trials
The registry lists 2,038 studies for Carcinoma, Renal Cell across more than 10 countries. 395 are recruiting or about to start. 1,435 of them are mainly about Carcinoma, Renal Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Clear-cell metastatic renal cell carcinoma too: 2,064 studies, 405 open.
ClinicalTrials.gov finds 2,514 studies for Carcinoma, Renal Cell. How that becomes 2,035 here
This page counts the studies the registry files under Carcinoma, Renal Cell, and those it files under no condition that list Carcinoma, Renal Cellthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,514Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −26Filed under a narrower condition, counted on its own pageClear-cell metastatic renal cell carcinoma 26
- −35List Carcinoma, Renal Cell as a condition, but the registry did not file them under itMost often written as “Advanced Renal Cell Carcinoma” (8), “Renal Cell Cancer Metastatic” (6), and “Renal Cell Carcinoma Metastatic” (4). The registry filed them under other conditions only, most often Kidney Neoplasms (12) and Prostatic Neoplasms (6).
- −419Match it another way86 name it in the title, 3 in a keyword, and 330 by a synonym or other text the search reads.
- 2,034Counted here and found by its search73 of them list Carcinoma, Renal Cell in their own words; the registry filed them under no condition.
- +1
Counted here, but its search does not find them
- 2,035The count on this page
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Status
Who runs them
National Cancer Institute (NCI) (116) · Pfizer (75) · M.D. Anderson Cancer Center (56) · Novartis Pharmaceuticals (35) · Bristol-Myers Squibb (32) · Bayer (29) · Memorial Sloan Kettering Cancer Center (29) · Merck Sharp & Dohme LLC (25)
What is being tested here
Drugs under test in Carcinoma, Renal Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pembrolizumab | 15 | 6 | 45 |
| Lenvatinib | 12 | 2 | 28 |
| Cabozantinib | 11 | 6 | 41 |
| Nivolumab | 9 | 8 | 62 |
| Axitinib | 9 | 4 | 37 |
| Zanzalintinib | 8 | 3 | 9 |
| Toripalimab | 6 | 1 | 9 |
| Ipilimumab | 5 | 4 | 27 |
| Belzutifan | 5 | 5 | 18 |
| Anti-CD70 CAR-expressing T Lymphocytes | 5 | 0 | 5 |
Drug classes tested here Immune checkpoint inhibitors 65 open · Tyrosine kinase inhibitors (TKIs) 56 open · Angiogenesis inhibitors 4 open · Antimetabolites 4 open · mTOR inhibitors 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Avelumab Program Rollover Study · Phase 3 · EMD Serono Research & Development Institute, Inc.
- Dec 2026Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma · Phase 3 · Exelixis
- Dec 2026A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV) · Phase 3 · Xynomic Pharmaceuticals, Inc.
- Jan 2027Treatment Pause Versus Treatment Continuation in IMDC Good or Intermediate Risk With Only One Adverse Prognostic Factor in mRCC Patients With an Objective Response at 12 Months of Treatment With PD1/ PDL1 ICIs + VEGFR-Tyrosine Kinase Inhibitors · Phase 3 · University Hospital, Bordeaux
- Mar 2027A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer · Phase 3 · Bristol-Myers Squibb
- Jun 2027Benmelstobart Plus Anlotinib Versus Sunitinib as First-Line Treatment for Advanced Non-Clear Cell Renal Cell Carcinoma · Phase 3 · Sun Yat-sen University
- Aug 2027Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study · Phase 3 · ECOG-ACRIN Cancer Research Group
- Aug 2027Phase 3 Study to Assess Safety and Efficacy of 177Lu-TLX250 in Advanced Relapsed or Recurrent ccRCC · Phase 3 · Telix Pharmaceuticals (Innovations) Pty Limited
- Oct 2027R.E.C.K vs Exparel in Robotic Nephrectomy · Phase 3 · Wake Forest University Health Sciences
- Nov 2026A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma · HiberCell, Inc.
Who these studies take
Of the 307 Carcinoma, Renal Cell studies recruiting now, 254 (83%) set no upper age limit and 18 (6%) stop at 75 or younger. 20 (7%) take children under 18. 0 (0%) are for women only and 2 (1%) for men only; 19 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 14 (5%) | 14 (5%) |
| 18 | 296 (96%) | 298 (97%) |
| 30 | 300 (98%) | 302 (98%) |
| 40 | 300 (98%) | 302 (98%) |
| 50 | 300 (98%) | 302 (98%) |
| 65 | 302 (98%) | 304 (99%) |
| 75 | 299 (97%) | 301 (98%) |
| 85 | 268 (87%) | 270 (88%) |
Across all 2,038 studies, recruiting or not: 7% stop at 75 or younger and 2% at 65; 8% take children; <1% are for women only and <1% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Carcinoma, Renal Cell studies take
Of 230 phase 2 interventional studies under Carcinoma, Renal Cell, half reached primary completion within 58 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 50 mo32–72 · 219 studies | 49 mo32–63 · 138 studies | 54 mo31–76 · 81 studies |
| Phase 1/2 | 64 mo45–87 · 111 studies | 67 mo44–78 · 70 studies | 64 mo45–132 · 41 studies |
| Phase 2 | 58 mo33–94 · 230 studies | 33 mo24–52 · 47 studies | 67 mo41–98 · 183 studies |
| Phase 3 | 56 mo42–89 · 61 studies | 49 mo31–59 · 35 studies | — |
| Interventional, no phase | 45 mo22–114 · 126 studies | — | 48 mo24–114 · 119 studies |
| Observational | 50 mo33–94 · 139 studies | 48 mo36–91 · 42 studies | 50 mo26–241 · 97 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Results posted1
Stopped4
- Kidney-protective Intervention With Salt Substitute After Kidney Tumor SurgeryTerminatedNov 9, 2026NCT07062952
- Molecular Residual Disease (MRD) Guided Adjuvant ThErapy in Renal Cell Carcinoma (RCC)TerminatedNov 3, 2026NCT06005818
- A Phase 1 Trial of ADI-270 in ccRCCTerminatedOct 27, 2026NCT06480565
- A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor NaiveTerminatedOct 20, 2026NCT05879822
Newly registered11
- Phase Ib/II Clinical Study of QLS5133 Combination Therapy in Advanced Solid TumorsNov 12, 2026NCT07933419
- Lenvatinib And Stereotactic radiothErapy With pembRolizumab in Metastatic Kidney Cancer PatientsNov 10, 2026NCT07928167
- Lifileucel (TIL) Therapy After PD-1 Blockade Failure in Kidney CancerNov 9, 2026NCT07925333
- Pucotenlimab, Lenvatinib, and SBRT Before Surgery for Localized Clear Cell Renal Cell CarcinomaNov 6, 2026NCT07922915
- Prospective Study of Cadonilimab With Lenvatinib in Renal Cell CarcinomaNov 2, 2026NCT07909265
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- The Edison™ System for Treatment of Renal Tumors Using Histotripsy (Histo-Renal Trial)Nov 2, 2026NCT07911527
- Habitat Analysis of Tumor Thrombus for Vena Cava Wall Invasion in Renal Cell CarcinomaOct 28, 2026NCT07901569
- A Clinical Study of Ivonescimab in Combination With Cadonilimab or Ipilimumab for Advanced Renal CancerOct 16, 2026NCT07877194
- Plasma DNA Methylation for Preoperative Classification of Renal MassesOct 15, 2026NCT07874542
- 68Ga- and 18F-CAIX PET Imaging StudyOct 15, 2026NCT07875946
- 18F-N230A PET/CT Imaging of Nectin-4 Expression in Renal TumorsOct 15, 2026NCT07875959
Studies
Recruiting first, then most recently updated. Showing 50 of 2,038. Browse all 2,038 → or search them.
- Registry Platform Urologic CancerRecruitingNCT033742671 country
- Phase Ib/II Clinical Study of QLS5133 Combination Therapy in Advanced Solid TumorsNot yet recruitingNCT07933419Phase 1/21 country
- GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Relapsed/Refractory GPNMB-Expressing Solid TumoursRecruitingNCT07297667Phase 11 country
- Belzutifan's Role in Active Surveillance Versus Treatment for Indolentmetastatic Clear Cell Renal Ccell Carcinoma (BRAVE-RCC)RecruitingNCT07023432Phase 21 country
- Pembrolizumab Plus Belzutifan With or Without Lenvatinib in Localized Renal Cell CarcinomaNot yet recruitingNCT07593040Phase 21 country
- Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell CarcinomaRecruitingNCT05155033Phase 21 country
- Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsRecruitingNCT03866382Phase 22 countries
- A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid TumorsRecruitingNCT06270706Phase 12 countries
- A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)RecruitingNCT07227402Phase 324 countries
- Use of Tracking Devices to Locate Abnormalities During Invasive ProceduresEnrolling by invitationNCT00102544Not applicable1 country
- Lenvatinib And Stereotactic radiothErapy With pembRolizumab in Metastatic Kidney Cancer PatientsRecruitingNCT07928167Phase 21 country
- A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)RecruitingNCT07489495Phase 319 countries
- Phase II Trial of Single Agent Belzutifan or Pembrolizumab Versus Combination as Neoadjuvant Therapy in Clear Cell Renal Cell Carcinoma (BLAZE)RecruitingNCT07187778Phase 21 country
- Lifileucel (TIL) Therapy After PD-1 Blockade Failure in Kidney CancerNot yet recruitingNCT07925333Phase 21 country
- Pucotenlimab, Lenvatinib, and SBRT Before Surgery for Localized Clear Cell Renal Cell CarcinomaNot yet recruitingNCT07922915Phase 2
- Toripalimab and Lenvatinib With or Without SBRT Before Surgery for Non-Clear Cell Kidney CancerNot yet recruitingNCT07922928Phase 2
- Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)RecruitingNCT04198766Phase 1/24 countries
- A Study of IBR854 Combined With Pazopanib Versus Pazopanib in Advanced Renal Cell CarcinomaRecruitingNCT07087158Phase 21 country
- A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other TumorsRecruitingNCT03972657Phase 1/22 countries
- Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant DisordersRecruitingNCT000012381 country
- Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell CarcinomaRecruitingNCT05830058Phase 21 country
- Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell CarcinomaRecruitingNCT07300241Phase 11 country
- Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer DetectionRecruitingNCT053340691 country
- Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney CancerRecruitingNCT06661720Phase 31 country
- A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid TumorsRecruitingNCT07636785Phase 1/21 country
- Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid TumorsRecruitingNCT05856981Phase 13 countries
- Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCCRecruitingNCT05663710Phase 1/21 country
- A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid TumorsRecruitingNCT05536141Phase 14 countries
- Prospective Study of Cadonilimab With Lenvatinib in Renal Cell CarcinomaRecruitingNCT07909265Phase 21 country
- The Edison™ System for Treatment of Renal Tumors Using Histotripsy (Histo-Renal Trial)Not yet recruitingNCT07911527Not applicable
- Federated Learning in Renal Tumor ModelNot yet recruitingNCT078417561 country
- Radiotherapy in Combination With Checkpoint Inhibition for Patients With Metastatic Kidney CancerRecruitingNCT06601296Phase 21 country
- Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing CancersRecruitingNCT02830724Phase 1/21 country
- A Phase III Randomized Controlled Trial of Serplulimab Plus Fruquintinib as Adjuvant Therapy for High-Risk Non-Clear Cell Renal Cell CarcinomaNot yet recruitingNCT07904156Phase 3
- Habitat Analysis of Tumor Thrombus for Vena Cava Wall Invasion in Renal Cell CarcinomaNot yet recruitingNCT079015691 country
- Study of ACC-1898 in Adult Participants With Advanced Solid TumorsNot yet recruitingNCT07252661Phase 1
- Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney CancerRecruitingNCT04981509Phase 21 country
- Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored StudyEnrolling by invitationNCT07620574Phase 31 country
- A Study of MGC026 in Participants With Advanced Solid TumorsRecruitingNCT06242470Phase 13 countries
- Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)RecruitingNCT07049926Phase 1/28 countries
- A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors.Not yet recruitingNCT07689812Not applicable
- Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell ManufacturingRecruitingNCT049811191 country
- Neoadjuvant Belzutifan Plus Pembrolizumab in High-Risk, Locally Advanced Clear Cell Renal Cell CarcinomaNot yet recruitingNCT07840001Phase 21 country
- Sequential Treatment of Cabozantinib for Advanced Renal Cell Carcinoma (RCC)RecruitingNCT05931393Phase 21 country
- Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI TrialRecruitingNCT05327686Phase 24 countries
- Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell CancerRecruitingNCT07226544Phase 21 country
- A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Other Agents in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)RecruitingNCT07293351Phase 1/220 countries
- A Phase 1 Study of the Safety and Tolerability of CTX-10726RecruitingNCT07419841Phase 11 country
- A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)RecruitingNCT06835972Phase 1/21 country
- An Exploratory Study on the Failure of Immunotherapy With Vorolanib Combined With EverolimusRecruitingNCT06730672Phase 21 country