Choroidal Neovascularization clinical trials
The registry lists 214 studies for Choroidal Neovascularization across more than 10 countries. 12 are recruiting or about to start. 95 of them are mainly about Choroidal Neovascularization (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05. Counting its narrower condition Polypoidal Choroidal Vasculopathy too: 260 studies, 18 open.
Get an email when these change. Save the Choroidal Neovascularization studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Novartis Pharmaceuticals (21) · National Eye Institute (NEI) (11) · Novartis (8) · Notal Vision Ltd. (7) · Medical University of Vienna (6) · Johns Hopkins University (5) · GlaxoSmithKline (5) · Chengdu Kanghong Biotech Co., Ltd. (4)
What is being tested here
Drugs under test in Choroidal Neovascularization studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Faricimab | 2 | 1 | 6 |
| EYE201 | 2 | 2 | 2 |
| Ranibizumab | 0 | 12 | 43 |
| Bevacizumab | 0 | 7 | 14 |
| Brolucizumab | 0 | 6 | 9 |
| Aflibercept | 0 | 1 | 7 |
| Verteporfin | 0 | 2 | 6 |
| Pazopanib | 0 | 0 | 4 |
| Triamcinolone Acetonide | 0 | 2 | 4 |
| Triamcinolone | 0 | 2 | 4 |
Drug classes tested here Angiogenesis inhibitors 2 open · Tyrosine kinase inhibitors (TKIs) 7 · Corticosteroids 7 · mTOR inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Dec 2026Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD · Phase 3 · AbbVie
- Jan 2027Biomarkers and Choroidal Neovascularization · Institut National de la Santé Et de la Recherche Médicale, France
- Jul 2027AVIGA3 (Cohort 2.0) · Tan Tock Seng Hospital
- Aug 2027Impact of Non-Exudative Type 1 MNV on AMD Progression · University of Utah
Who these studies take
Of the 6 Choroidal Neovascularization studies recruiting now, 4 (67%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 2 (33%) | 2 (33%) |
| 30 | 2 (33%) | 2 (33%) |
| 40 | 2 (33%) | 2 (33%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 6 (100%) | 6 (100%) |
| 85 | 6 (100%) | 6 (100%) |
Across all 214 studies, recruiting or not: 7% stop at 75 or younger and 5% at 65; 10% take children; 0% are for women only and <1% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Choroidal Neovascularization studies take
Of 15 phase 3 interventional studies under Choroidal Neovascularization, half reached primary completion within 27 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 27 mo23–35 · 15 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 214. Browse all 214 → or search them.
- A Study to Evaluate the Efficacy and Safety of VIS-101 in Participants With Neovascular Age-Related Macular DegenerationNot yet recruitingNCT07798375Phase 2
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)RecruitingNCT07440225Phase 2/312 countries
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)RecruitingNCT07496567Phase 2/39 countries
- Biomarkers and Choroidal NeovascularizationRecruitingNCT044397081 country
- AVIGA3 (Cohort 2.0)RecruitingNCT07255859Not applicable1 country
- Deep Learning-Based OCTA Quantification and Modeling for Predicting Long-Term Anti-VEGF Efficacy in mCNVNot yet recruitingNCT07402629
- Faricimab Quarterly Maintenance for Neovascular Age Related Macular DegenerationRecruitingNCT06742307Phase 41 country
- Long Term Efficacy of Faricimab Using a Treat and Extend Regimen for Type 3 Macular NeovascularizationNot yet recruitingNCT07187804Phase 41 country
- The Treatment Burden of Myopic Choroidal NeovascularizationNot yet recruitingNCT070095741 country
- Effect of Video Viewing on Intravitreal Injection ExperienceRecruitingNCT07002372Not applicable1 country
- An Interpretable Fundus Diseases Report Generating System Based On Weakly LabelingsNot yet recruitingNCT069180281 country
- Study on the Biomarkers of Anti-VEGF Treatment for Choroidal NeovascularizationNot yet recruitingNCT06243406
- Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA]Active, not recruitingNCT05536973Phase 23 countries
- NG101 AAV Gene Therapy in Subjects With Wet Age-Related Macular DegenerationActive, not recruitingNCT05984927Phase 1/22 countries
- Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMDActive, not recruitingNCT05407636Phase 310 countries
- A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic MyopiaCompletedNCT06176352Phase 311 countries
- Switching to Aflibercept 8mg in Patients Showing Limited Response to Previous TreatmentCompletedNCT06683950Phase 41 country
- OCT and Microperimetry in Patients With Active Neovascular ARMD (CORFI)WithdrawnNCT034359261 country
- Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMDActive, not recruitingNCT04704921Phase 2/31 country
- Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]Active, not recruitingNCT046452121 country
- Impact of Non-Exudative Type 1 MNV on AMD ProgressionActive, not recruitingNCT061259771 country
- Efficacy and Safety of Two Different Brolucizumab 6 mg Dosing Regimens in Neovascular Age-related Macular DegenerationCompletedNCT04679935Phase 42 countries
- Study Evaluating the Efficacy of Aflibercept for the Treatment of Inflammatory CNV in Young Patients (ALINEA).CompletedNCT02556229Phase 21 country
- Study Evaluating the Efficacy of Aflibercept for the Treatment of NVCI in Young PatientsCompletedNCT02257502Phase 21 country
- Comparing Post-intravitreal Injection Pain Scores Using Loteprednol, Bromfenac Sodium, and Artificial Tears Over a 24-hour PeriodCompletedNCT07090044Phase 41 country
- Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab.CompletedNCT04774926Phase 41 country
- Photodynamic Therapy Combined With Bevacizumab vs Bevacizumab Alone for Neovascular Age-related Macular DegenerationWithdrawnNCT00696592Phase 21 country
- Study to Evaluate the Safety and Effectiveness of Intravitreal Injections (IVI) of Brolucizumab in Patients With Neovascular Age-related Macular Degeneration (nAMD)CompletedNCT05269966Phase 41 country
- Efficacy and Safety of RTH258 Versus Aflibercept - Study 2CompletedNCT02434328Phase 3
- Efficacy and Safety of RTH258 Versus Aflibercept - Study 1CompletedNCT02307682Phase 31 country
- Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular DegenerationCompletedNCT04264819Phase 31 country
- A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Either Avastin® or Eylea® Compared to Avastin® or Eylea® MonotherapyTerminatedNCT01940887Phase 322 countries
- Efficacy and Safety of Intravitreal Bevacizumab in the Treatment of Choroidal Neovascular Membranes Associated to High MyopiaCompletedNCT00967850Phase 31 country
- A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® MonotherapyTerminatedNCT01944839Phase 313 countries
- A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® MonotherapyTerminatedNCT01940900Phase 311 countries
- An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) StudyCompletedNCT04597632Phase 316 countries
- Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)CompletedNCT04005352Phase 320 countries
- A Study to Assess the Effects of Brolucizumab in Adult Patients With Neovascular Age Related Macular DegenerationCompletedNCT04239027Phase 31 country
- Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid StreaksTerminatedNCT00599820Phase 31 country
- Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)TreatmentTerminatedNCT00417833Phase 2/3
- Efficacy of Retreatments With Intravitreal BevacizumabTerminatedNCT00406744Phase 31 country
- Deep Learning Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) in NVCCompletedNCT059694181 country
- Phase 2A Open Label Safety Study of Fovista® (Anti-PDGF BB) Regimen Administered in Combination With Anti-VEGF Therapy to Study Sub-Retinal Fibrosis in Neovascular AMDTerminatedNCT02214628Phase 21 country
- Outcomes of Tolerating Subretinal Fluid in Type 1 MNV and PCVCompletedNCT056629431 country
- Episcleral Brachytherapy for the Treatment of Wet AMDActive, not recruitingNCT02988895Not applicable1 country
- A Study to Learn More About How Drug Aflibercept Works in Canadian Patients With Reduced Vision Caused by New Blood Vessels Growing in the Eye (Myopic Choroidal Neovascularization or mCNV)CompletedNCT045249101 country
- Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMDCompletedNCT03024424Not applicable1 country
- A Randomized, Double-masked, Multicenter,Sham-controlled, Safety and Efficacy Study of KH902 in Patients With Wet AMDCompletedNCT01436864Phase 31 country
- Intravitreal Conbercept Injection in Patients With Myopic Choroidal NeovascularizationCompletedNCT03971162Not applicable1 country
- Initial Treatment With Bevacizumab in Choroidal Neovascularization Associated to High MyopiaCompletedNCT01716026Phase 31 country