Macular Edema clinical trials
The registry lists 756 studies for Macular Edema across more than 10 countries. 65 are recruiting or about to start. 555 of them are mainly about Macular Edema (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 1,117 studies for Macular Edema. How that becomes 755 here
This page counts the studies the registry files under Macular Edema, and those it files under no condition that list Macular Edemathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,117Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −198List Macular Edema as a condition, but the registry did not file them under itMost often written as “Diabetic Macular Edema” (155), “Diabetic Macular Edema (DME)” (22), and “Central Retinal Vein Occlusion With Macular Edema” (5). The registry filed them under other conditions only, most often Diabetic Retinopathy (98) and Macular Degeneration (39).
- −164Match it another way108 name it in the title, 23 in a keyword, and 33 by a synonym or other text the search reads.
- 755The count on this page337 of them list Macular Edema in their own words; the registry filed them under no condition.
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Who runs them
Novartis Pharmaceuticals (36) · Allergan (30) · National Eye Institute (NEI) (24) · Hoffmann-La Roche (17) · Shahid Beheshti University of Medical Sciences (17) · Bayer (16) · Genentech, Inc. (11) · Johns Hopkins University (10)
What is being tested here
Drugs under test in Macular Edema studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 2 | 11 | 36 |
| Triamcinolone | 1 | 14 | 28 |
| Bevacizumab | 1 | 12 | 26 |
| Triamcinolone Acetonide | 1 | 8 | 17 |
| Nepafenac | 1 | 3 | 14 |
| Bromfenac | 1 | 2 | 7 |
| Minocycline | 1 | 0 | 3 |
| Dexamethasone phosphate | 1 | 1 | 3 |
| Diclofenac | 1 | 0 | 3 |
| Adalimumab | 1 | 1 | 1 |
Drug classes tested here Corticosteroids 3 open · Angiogenesis inhibitors 1 open · NSAIDs 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027A Study of 2 Doses of Remigromig (EYE103) Compared With Ranibizumab (0.5 mg) in Participants With DME · Phase 3 · EyeBiotech Ltd.
- Feb 2027A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE · Phase 3 · Kodiak Sciences Inc
- Apr 2027A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK · Phase 3 · Kodiak Sciences Inc
- Apr 2027Efficacy Evaluation Study of BAT5906 and Lucentis® in Patients With Diabetic Macular Edema · Phase 3 · Bio-Thera Solutions
- Jun 2027Treatment FOr Corticosteroid Dependent UveitiS · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Jul 2027Efficacy and Safety Evaluation of SMO1 in Patients With Retinal Vein Occlusive Macular Edema · Phase 3 · SANGMYUNG innovation
- Jul 2027Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With Diabetic Macular Edema · Phase 3 · Alvotech Swiss AG
- Jul 2027A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME · Phase 3 · Hoffmann-La Roche
- Oct 2027CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- Oct 2027COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
Who these studies take
Of the 44 Macular Edema studies recruiting now, 31 (70%) set no upper age limit and 7 (16%) stop at 75 or younger. 1 (2%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 37 (84%) | 37 (84%) |
| 30 | 40 (91%) | 40 (91%) |
| 40 | 43 (98%) | 43 (98%) |
| 50 | 43 (98%) | 43 (98%) |
| 65 | 43 (98%) | 43 (98%) |
| 75 | 37 (84%) | 37 (84%) |
| 85 | 34 (77%) | 34 (77%) |
Across all 756 studies, recruiting or not: 6% stop at 75 or younger and 2% at 65; 10% take children; <1% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Macular Edema studies take
Of 65 phase 3 interventional studies under Macular Edema, half reached primary completion within 25 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 24 mo11–51 · 25 studies | — | — |
| Phase 1/2 | 46 mo23–68 · 16 studies | — | — |
| Phase 2 | 19 mo15–32 · 50 studies | 18 mo14–28 · 32 studies | — |
| Phase 3 | 25 mo18–38 · 65 studies | 24 mo18–33 · 52 studies | — |
| Phase 4 | 26 mo15–43 · 63 studies | — | 28 mo15–43 · 51 studies |
| Interventional, no phase | 21 mo9–37 · 50 studies | — | 21 mo10–42 · 46 studies |
| Observational | 25 mo12–52 · 44 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 756. Browse all 756 → or search them.
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)RecruitingNCT07425522Phase 11 country
- Oral N-Acetylcysteine on Diabetic Macular EdemaRecruitingNCT07917338Phase 21 country
- A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)RecruitingNCT07705607Phase 31 country
- A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)RecruitingNCT07705555Phase 34 countries
- A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTORecruitingNCT07734844Phase 32 countries
- Suprachoroidal Bevacizumab Versus Intravitreal Bevacizumab in Diabetic Macular EdemaEnrolling by invitationNCT07897630Phase 31 country
- Study of CU06-1004 in Patients With Daibetic Macular EdemaNot yet recruitingNCT07459829Phase 2
- Imaging Retinal Vasculature in Infant EyesRecruitingNCT055580591 country
- A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular EdemaRecruitingNCT06962839Phase 29 countries
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are ToleratedRecruitingNCT07553429Phase 1/22 countries
- Suprachoroidal Triamcinolone Acetonide Monotherapy in Treatment-naive Center Involving Diabetic Macular EdemaNot yet recruitingNCT07870226Phase 2
- OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil RemovalNot yet recruitingNCT07865468
- Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular EdemaRecruitingNCT07383701Phase 21 country
- MIND-AMD Study: a Multidisciplinary Investigation of Neuroretinal Damage in Age-related Macular Degeneration.Not yet recruitingNCT07847151
- A First-in-human Trial of SZN-8141 in Diabetic Macular EdemaNot yet recruitingNCT07817121Phase 1
- Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular EdemaRecruitingNCT06825702Phase 21 country
- South Asian Patients With Diabetic Macular Oedema Treated With Faricimab Assessing the Efficacy, Durability, and Safety (SEAFAR Study)Not yet recruitingNCT07753616Phase 4
- Phase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME)RecruitingNCT05802329Phase 11 country
- Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma CenterNot yet recruitingNCT07519707Not applicable1 country
- Efficacy and Safety Evaluation of SMO1 in Patients With Retinal Vein Occlusive Macular EdemaRecruitingNCT07708142Phase 31 country
- Evaluating the Safety and Tolerability of Orally Administered DF-003 in ROSAH Syndrome PatientsRecruitingNCT06395285Phase 13 countries
- Zhuochuming®-3T&E-DME Study (Treatment-naïve Patients)Not yet recruitingNCT07612904Phase 41 country
- A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLERecruitingNCT06996080Phase 32 countries
- A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAKRecruitingNCT06990399Phase 32 countries
- Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With Diabetic Macular EdemaRecruitingNCT07489131Phase 31 country
- Efficacy Evaluation Study of BAT5906 and Lucentis® in Patients With Diabetic Macular EdemaRecruitingNCT07515079Phase 31 country
- Safety and Efficacy Evaluation of LX111 Gene Therapy in DME PatientsRecruitingNCT07362927Early Phase 11 country
- Kamuvudine-9 (K9) in Diabetic Macular EdemaRecruitingNCT07458061Phase 1/21 country
- Efficacy Comparison of DExamethasone Intravitreal Implant Combined With Aflibercept Versus Aflibercept Monotherapy in Treatment-naïve Inflammatory Diabetic Macular Edema PatientsNot yet recruitingNCT07438119Phase 4
- Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion TreatmentRecruitingNCT07133438Phase 41 country
- Comparison of Bevacizumab and Aflibercept in Treatment of Diabetic Macular EdemaEnrolling by invitationNCT07338097Not applicable1 country
- Micropulse Laser in Treatment of Initial and Refractory Cases of Center-Involved Diabetic Macular EdemaRecruitingNCT072957041 country
- Micropulse Laser Photocoagulation in Diabetic Macular EdemaNot yet recruitingNCT07266597Not applicable
- Therapeutic Contact Lens Drug Delivery System (TCL-DDS) in Patients With Recurrent Cystoid Macular EdemaRecruitingNCT04225611Phase 1/21 country
- OCT-Based Screening for Early Retinal Changes in Asymptomatic Diabetic PatientsNot yet recruitingNCT07232225
- Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular EdemaRecruitingNCT03161652Phase 21 country
- High Resolution, High-speed Multimodal Ophthalmic ImagingRecruitingNCT04129021Not applicable1 country
- A Phase 2a Study to Evaluate the Safety, Tolerability, and Efficacy of SNP318 in DME PatientsNot yet recruitingNCT07199777Phase 2
- MS-553 in Diabetic Retinopathy Patients With Central Involved Macular EdemaRecruitingNCT04187443Phase 11 country
- Comparing Efficacy of Bromfenac 0.09%, Nepafenac 0.3% and Diclofenac 0.1% in Patients After Cataract SurgeryRecruitingNCT07178639Not applicable1 country
- Evaluation of Retinal Parameters in Patients With Epiretinal Membrane After VitrectomyEnrolling by invitationNCT07165626Not applicable1 country
- Suprachoroidal Triamcinolone in Macular Edema for Patients With Non-Infectious Uveitis Resistant to Subtenon TriamcinolonRecruitingNCT07145008Early Phase 11 country
- Non-Center Involving Diabetic Macular Edema Progression in Early Postoperative Period After PhacoemulsificationRecruitingNCT070389671 country
- Minimal Vitrectomy Surgery for Epiretinal MembraneRecruitingNCT07019896Not applicable1 country
- Effect of Video Viewing on Intravitreal Injection ExperienceRecruitingNCT07002372Not applicable1 country
- Medico Economic Evaluation of Fluocinolone Acetonide Implant Versus Dexametheasone Implant in Resistant Diabetic Macular OedemaRecruitingNCT04910503Phase 41 country
- Intravitreal and Intracameral DEX in NPDREnrolling by invitationNCT06951087Phase 31 country
- Phase 2 Trial of RGX-314 in Adults With Center Involved - Diabetic Macular Edema (CI - DME)RecruitingNCT06942520Phase 21 country
- Implementation of the Intravitreal Injection Administered by NursesEnrolling by invitationNCT065117001 country
- Micropulsed Laser in Patients with Macular Oedema in Retinal DystrophiesRecruitingNCT05976139Not applicable1 country