Polypoidal Choroidal Vasculopathy clinical trials
The registry lists 54 studies for Polypoidal Choroidal Vasculopathy across more than 10 countries. 6 are recruiting or about to start. 42 of them are mainly about Polypoidal Choroidal Vasculopathy (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-25.
Get an email when these change. Save the Polypoidal Choroidal Vasculopathy studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Singapore National Eye Centre (4) · Southeast Retina Center, Georgia (3) · Sun Yat-sen University (3) · Yeungnam University College of Medicine (3) · Samsung Medical Center (2) · Ophthotech Corporation (2) · Peking Union Medical College Hospital (2) · Association for Innovation and Biomedical Research on Light and Image (2)
What is being tested here
Drugs under test in Polypoidal Choroidal Vasculopathy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Faricimab | 2 | 1 | 2 |
| Aflibercept | 1 | 1 | 10 |
| Ranibizumab | 0 | 0 | 8 |
| Avacincaptad pegol | 0 | 0 | 2 |
| Verteporfin | 0 | 0 | 2 |
| Bevacizumab | 0 | 1 | 2 |
| Brolucizumab | 0 | 1 | 1 |
| Fosbretabulin | 0 | 0 | 1 |
| Sonepcizumab | 0 | 0 | 1 |
| Triamcinolone Acetonide | 0 | 0 | 1 |
Drug classes tested here Angiogenesis inhibitors 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
Who these studies take
Of the 5 Polypoidal Choroidal Vasculopathy studies recruiting now, 3 (60%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (20%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (20%) | 1 (20%) |
| 18 | 1 (20%) | 1 (20%) |
| 30 | 2 (40%) | 2 (40%) |
| 40 | 2 (40%) | 2 (40%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 5 (100%) | 5 (100%) |
Across all 54 studies, recruiting or not: 0% stop at 75 or younger and 0% at 65; 7% take children; 0% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 54. Browse all 54 → or search them.
- Safety and Efficacy Evaluation of SMZ1 With Ranibizumab in Patients With Neovascular Age-related Macular Degeneration Without Polypoidal Choroidal VasculopathyRecruitingNCT07695207Phase 31 country
- Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal VasculopathyRecruitingNCT07461441Phase 31 country
- Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)RecruitingNCT06709339Phase 44 countries
- Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS TrialRecruitingNCT07389980Phase 31 country
- A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV)Not yet recruitingNCT07365371Phase 41 country
- OCT in Rare Chorioretinal DiseasesRecruitingNCT021413081 country
- Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and SafetyActive, not recruitingNCT07481500Not applicable1 country
- Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal VasculopathyCompletedNCT05666804Phase 31 country
- Comparing Intravitreal Aflibercept Monotherapy vs Aflibercept Combined With Reduced Fluence PDT in PCV TreatmentCompletedNCT03941587Not applicable1 country
- Long-term Outcomes, Recurrence Rates, and Treatment Needs in Polypoidal Choroidal Vasculopathy (PCV)CompletedNCT039297311 country
- A Study to Establish the Safety and Tolerability of Zimura™ (Anti-C5 Aptamer) in Combination With Anti-VEGF Therapy in Subjects With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)CompletedNCT02397954Phase 21 country
- ZIMURA in Combination With Eylea in Patients With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)WithdrawnNCT03374670Phase 21 country
- Outcomes of Tolerating Subretinal Fluid in Type 1 MNV and PCVCompletedNCT056629431 country
- Safety Study of 2.0mg Lucentis to Treat Polypoidal Choroidal VasculopathyCompletedNCT01469156Phase 1/21 country
- Clinical Implication of Aflibercept in PCV Treatment in ChinaStatus unknownNCT056396601 country
- Conbercept for Polypoidal Choroidal Vasculopathy(START Study)CompletedNCT052292371 country
- An Open Label-study to Compare the Efficacy of Aflibercept Monotherapy for Polypoidal Choroidal VasculopathyCompletedNCT03117634Phase 41 country
- Eyes That Do Not Meet the Eligibility Criteria of Clinical Trials on Age-Related Macular Degeneration: Proportion of the Real-World Patient Population and Reasons for ExclusionCompletedNCT048361431 country
- OCTA and Polypoidal Choroidal VasculopathyCompletedNCT047142421 country
- Interval of Disease Inactivity After Complete Polypoidal Regression in PCV Receiving AfliberceptStatus unknownNCT04707027Not applicable1 country
- Intravitreal Aflibercept for Treatment of Polypoidal Choroidal Vasculopathy (PCV)CompletedNCT02860858Phase 41 country
- Efficacy and Safety of Two Regimens of Anti-VEGF Therapy in Chinese Patients With Polypoidal Choroidal VasculopathyStatus unknownNCT04380974Phase 41 country
- Randomized, Double-masked, Sham-controlled Phase 4 Study, Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept With Adjunctive Photodynamic Therapy in Patients With Polypoidal Choroidal VasculopathyCompletedNCT02495181Phase 42 countries
- Intraocular Cytokine in Recurrence of Polypoidal Choroidal VasculopathyStatus unknownNCT02976194Phase 41 country
- Biomarkers of Common Eye DiseasesStatus unknownNCT041016041 country
- Double-dose Ranibizumab for Polypoidal Choroidal VasculopathyTerminatedNCT02769169Phase 2/31 country
- Treatment of Polypoidal Choroidal Vasculopathy in PachychoroidCompletedNCT04075188Not applicable1 country
- Initial Versus Delayed PDT Combination With Conbercept in PCVCompletedNCT02821520Phase 41 country
- Visual Outcome in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV) Treated With Either Ranibizumab as Monotherapy or Combined With Verteporfin Photodynamic Therapy (vPDT)CompletedNCT01846273Phase 47 countries
- Ranibizumab (Lucentis) for Polypoidal Choroidal VasculopathyCompletedNCT00837330Phase 1/21 country
- Intravitreal Ranibizumab and TA Combination Therapy vs. Ranibizumab Monotherapy in Polypoidal Choroidal VasculopathyStatus unknownNCT02806752Phase 41 country
- Genetic Factors of Idiopathic Polypoidal Vasculopathies in the ATM Gene (Ataxia Telangiectasia Mutated)TerminatedNCT028578941 country
- Efficacy and Safety of Intravitreal Vascular Endothelial Growth Factor Trap-eye in Patients With Polyploidal Choroidal VasculopathyCompletedNCT02072408Phase 41 country
- Comparison of PDT, Intravitreal Ranibizumab and Combination for Polypoidal Choroidal Vasculopathy Under 1+PRN RegimenCompletedNCT03459144Not applicable1 country
- Assessment of Visual Acuity in Patients With Polypoidal Choroidal Vasculopathy and Aflibercept TreatmentCompletedNCT02381730Not applicable1 country
- Investigator Sponsored Trial of Polypoidal Choroidal Vasculopathy (PCV) Evaluation Assessing High-Dose Ranibizumab Prospectively (PEARL2)CompletedNCT01884597Phase 1/21 country
- The Efficacy Assessment of Intravitreal Injection of Conbercept in Patients With Polypoidal Choroidal Vasculopathy (PCV)Status unknownNCT03159884Phase 41 country
- Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular DiseasesStatus unknownNCT031284631 country
- Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or ExudationCompletedNCT01871376Phase 41 country
- Short-term Efficacy of Intravitreal Afilibercept Depending on Subtypes of Polypoidal Choroidal Vasculopathy: Polypoidal Choroidal Neovascularization or Idiopathic Choroidal VasculopathyStatus unknownNCT025978551 country
- Angiographic Characteristics of CSC, PCV Patients and Thrombotic Bio-markersStatus unknownNCT028151761 country
- Effect of Intravitreal VEGF-Trap Eye on Polypoidal Choroidal VasculopathyCompletedNCT01950741Phase 41 country
- Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal VasculopathyWithdrawnNCT01666236Phase 41 country
- Ranibizumab for Polypoidal Choroidal Vasculopathy (PCV)CompletedNCT00424710Phase 11 country
- Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial)Status unknownNCT02092532Phase 41 country
- iSONEP to Treat Persistent Pigment Epithelial Detachment (PED) in Subjects With Exudative Age-Related Macular Degeneration (AMD) or Polypoidal Choroidal Vasculopathy (PCV)TerminatedNCT01334255Phase 11 country
- Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related MaculopathyCompletedNCT00470977Phase 1/21 country
- Study Evaluating the Safety and Response of Fosbretabulin in Asian Patients With Polypoidal Choroidal Vasculopathy (PCV)CompletedNCT01023295Phase 25 countries
- Aqueous Humor Level of Cytokines in Polypoidal Choroidal Vasculopathy and Change of Cytokines After Photodynamic TherapyStatus unknownNCT01360151Not applicable1 country
- Efficacy and Safety of Verteporfin Added to Ranibizumab in the Treatment of Symptomatic Macular Polypoidal Choroidal VasculopathyCompletedNCT00674323Phase 45 countries