Tobacco Use clinical trials
The registry lists 420 studies for Tobacco Use across more than 10 countries. 82 are recruiting or about to start. 172 of them are mainly about Tobacco Use (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its 2 narrower conditions too, such as Cigarette Smoking: 1,012 studies, 180 open.
Get an email when these change. Save the Tobacco Use studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
RAI Services Company (42) · Mayo Clinic (13) · University of California, San Francisco (12) · Medical University of South Carolina (9) · University of Minnesota (9) · Altria Client Services LLC (9) · University of Oklahoma (9) · Duke University (8)
What is being tested here
Drugs under test in Tobacco Use studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product · RAI Services Company
- Dec 2026A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products · RAI Services Company
- Dec 2026Cardiovascular Effects of Very Low Nicotine Content Cigarettes · Wake Forest University Health Sciences
- Dec 2026A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers · RAI Services Company
- Dec 2026Oral Cannabidiol for Tobacco Cessation · Johns Hopkins University
- Dec 2026A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers · RAI Services Company
- Dec 2026Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers · British University In Egypt
- Dec 2026Tobacco-Concurrent Addictions in At-Risk Youth in Ottawa · Ottawa Hospital Research Institute
- Jan 2027Antibiotic Prophylaxis in High-Risk Arthroplasty Patients · Mayo Clinic
- Jan 2027Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in Dhaka · International Centre for Diarrhoeal Disease Research, Bangladesh
Who these studies take
Of the 50 Tobacco Use studies recruiting now, 28 (56%) set no upper age limit and 18 (36%) stop at 75 or younger. 2 (4%) take children under 18. 3 (6%) are for women only and 0 (0%) for men only; 27 (54%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (2%) | 1 (2%) |
| 18 | 25 (50%) | 22 (44%) |
| 30 | 42 (84%) | 39 (78%) |
| 40 | 45 (90%) | 42 (84%) |
| 50 | 47 (94%) | 44 (88%) |
| 65 | 46 (92%) | 43 (86%) |
| 75 | 33 (66%) | 30 (60%) |
| 85 | 29 (58%) | 26 (52%) |
Across all 420 studies, recruiting or not: 43% stop at 75 or younger and 39% at 65; 14% take children; 3% are for women only and 3% for men only; 66% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tobacco Use studies take
Of 223 interventional studies with no phase under Tobacco Use, half reached primary completion within 16 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 16 mo5–33 · 223 studies | 2 mo1–5 · 56 studies | 24 mo12–41 · 167 studies |
| Observational | 44 mo4–216 · 28 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting5
- Telegram Messenger Support for Smoking Cessation After Heart AttackNov 9, 2026NCT07230249
- Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department PatientsOct 27, 2026NCT07734727
- Smoking Cessation in Patients With CancerOct 26, 2026NCT07822464
- Automating Tobacco Cessation in Primary CareOct 21, 2026NCT07735286
- Smoking Relapse Prevention in Patients With CancerOct 21, 2026NCT07815912
Results posted2
- Study of EMB-001 as a Potential Smoking Cessation TreatmentNov 5, 2026NCT04933916
- Tobacco Cessation at FDNYNov 5, 2026NCT05997225
Newly registered4
- Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-SmokersNov 4, 2026NCT07915570
- §SMOKE Nicotine and Tobacco Youth CohortNov 2, 2026NCT07910331
- A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System ProductOct 20, 2026NCT07881848
- A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery SystemOct 19, 2026NCT07879638
Studies
Recruiting first, then most recently updated. Showing 50 of 420. Browse all 420 → or search them.
- Telegram Messenger Support for Smoking Cessation After Heart AttackRecruitingNCT07230249Not applicable1 country
- §SMOKE Nicotine and Tobacco Youth CohortRecruitingNCT079103311 country
- Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-SmokersRecruitingNCT079155701 country
- Developing a Scalable Tobacco Cessation Program for Cancer Survivors and CaregiversRecruitingNCT06851936Not applicable1 country
- Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department PatientsRecruitingNCT07734727Not applicable1 country
- Smoking Cessation in Patients With CancerRecruitingNCT07822464Not applicable1 country
- A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery SystemRecruitingNCT07879638Not applicable1 country
- STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for SmokingRecruitingNCT06922617Not applicable1 country
- Automating Tobacco Cessation in Primary CareRecruitingNCT07735286Not applicable1 country
- Smoking Relapse Prevention in Patients With CancerRecruitingNCT07815912Not applicable1 country
- A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System ProductNot yet recruitingNCT07881848Not applicable
- Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking CessationNot yet recruitingNCT07789496Not applicable1 country
- Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco MarketplaceEnrolling by invitationNCT06234722Not applicable1 country
- Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who SmokeRecruitingNCT06654414Not applicable1 country
- The ICEC Cluster Trial: Integrated Community Engagement Collaborative for Youth Substance Use Prevention in Rural AmericaNot yet recruitingNCT07843576Not applicable1 country
- A Community Health Intervention to Improve Lung Cancer Screening Uptake in Community Health CentersRecruitingNCT07168629Not applicable1 country
- Impact of Electronic Cigarette Temperature and Solvent on BiomarkersNot yet recruitingNCT07612696Not applicable1 country
- Metaphor-Based Smoking Cessation InterventionNot yet recruitingNCT07803354Not applicable1 country
- Overcoming Nicotine Dependence to Enable QuittingRecruitingNCT05513872Phase 1/21 country
- Evaluating Narrative Vaping Prevention Video Ads for Adolescents and Young AdultsNot yet recruitingNCT07767929Not applicable1 country
- Cardiovascular Effects of Very Low Nicotine Content CigarettesRecruitingNCT05707871Early Phase 11 country
- A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free HomeRecruitingNCT06693700Not applicable1 country
- A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science ResearchEnrolling by invitationNCT05852860Not applicable1 country
- The Effect of Motivational Interviewing on Smoking Behavior Among Nursing StudentsNot yet recruitingNCT07758998Not applicable1 country
- Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in DhakaNot yet recruitingNCT07746492Not applicable1 country
- A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System ProductsNot yet recruitingNCT07739797Not applicable
- Puff Topography and Sensory Effects Across IQOS Device GenerationsRecruitingNCT07712887Not applicable1 country
- Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, KenyaNot yet recruitingNCT06790342Phase 31 country
- A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette SmokersRecruitingNCT07710820Not applicable1 country
- Motivational Interviewing and Mindfulness-Oriented Recovery EnhancementRecruitingNCT06033599Phase 31 country
- A Mindfulness-based Intervention for Sexual Assault SurvivorsNot yet recruitingNCT07515586Not applicable1 country
- Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and PostpartumRecruitingNCT07489443Not applicable1 country
- Antibiotic Prophylaxis in High-Risk Arthroplasty PatientsEnrolling by invitationNCT04297592Phase 41 country
- Abuse Liability of Four Modern Oral Nicotine ProductsNot yet recruitingNCT07685795Not applicable
- Little Cigar OxidantsRecruitingNCT06310187Not applicable1 country
- Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to QuitRecruitingNCT07199517Not applicable1 country
- Integrating CHWs Into Prenatal Care for Maternal Smoking CessationRecruitingNCT06438549Not applicable1 country
- Neural Mechanisms Connecting Deficient Sleep and Smoking RelapseRecruitingNCT06609369Phase 21 country
- Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible SmokersRecruitingNCT047228351 country
- A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within SmokersRecruitingNCT07598136Not applicable1 country
- Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective EffectsRecruitingNCT07107139Not applicable1 country
- The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded StudyRecruitingNCT065358671 country
- Abuse Liability of Two Modern Oral Nicotine Pouched ProductsNot yet recruitingNCT07595055Not applicable
- Multilevel Intervention for LDCT Lung Cancer Screening and Smoking Cessation Among African AmericansRecruitingNCT07576595Not applicable1 country
- Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)RecruitingNCT07162935Not applicable1 country
- Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and BehaviorRecruitingNCT05572671Not applicable1 country
- Trial of a Harm Reduction Strategy for People With HIV Who Smoke CigarettesRecruitingNCT05642715Not applicable1 country
- RTMS Targets Neural Circuits for Smoking CessationRecruitingNCT04903028Not applicable1 country
- Effect of Cannabis on E-Cigarette Use BehaviorRecruitingNCT06609109Phase 11 country
- Robot-Assisted Immersive Escape Room Game for Tobacco Harm Prevention Among Elementary School StudentsEnrolling by invitationNCT07501572Not applicable1 country