Sialorrhea clinical trials
The registry lists 60 studies for Sialorrhea across more than 10 countries. 5 are recruiting or about to start. 37 of them are mainly about Sialorrhea (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Cairo University (4) · Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC (3) · NeuroHealing Pharmaceuticals Inc. (2) · Beersheva Mental Health Center (2) · Hospices Civils de Lyon (2) · Hacettepe University (2) · UbiVac (1) · Kırıkkale University (1)
What is being tested here
Drugs under test in Sialorrhea studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| rimabotulinumtoxinB | 0 | 4 | 5 |
| Botulinum toxin type A | 0 | 2 | 5 |
| Glycopyrrolate | 0 | 0 | 3 |
| Ipratropium | 0 | 0 | 3 |
| Atropine | 0 | 0 | 2 |
| Imiquimod | 0 | 0 | 1 |
| Scopolamine | 0 | 0 | 1 |
| Tropicamide | 0 | 0 | 1 |
| incobotulinumtoxinA | 0 | 1 | 1 |
| Lidocaine | 0 | 0 | 1 |
Drug classes tested here Antimuscarinics 9
Who these studies take
Of the 2 Sialorrhea studies recruiting now, 0 (0%) set no upper age limit and 1 (50%) stop at 75 or younger. 2 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (50%) | 1 (50%) |
| 18 | 1 (50%) | 1 (50%) |
| 30 | 1 (50%) | 1 (50%) |
| 40 | 1 (50%) | 1 (50%) |
| 50 | 1 (50%) | 1 (50%) |
| 65 | 1 (50%) | 1 (50%) |
| 75 | 1 (50%) | 1 (50%) |
| 85 | 1 (50%) | 1 (50%) |
Across all 60 studies, recruiting or not: 53% stop at 75 or younger and 52% at 65; 42% take children; 0% are for women only and 3% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Studies
Recruiting first, then most recently updated. Showing 50 of 60. Browse all 60 → or search them.
- Application of Neuro-electrostimulation as a Treatment for Patients With Dry MouthRecruitingNCT07593495Not applicable1 country
- Effectiveness of Neuromuscular Electrical Stimulation Added to Oral Motor Therapy in Cerebral PalsyNot yet recruitingNCT07069257Not applicable1 country
- Chewing Gum as a Therapeutic Intervention for the Management of HypersalivationNot yet recruitingNCT07158359Not applicable
- Oral Structural and Functional Problems in Children With AutismNot yet recruitingNCT06355141
- Effects of Mollii Suit in Children With Non-Ambule Cerebral PalsyRecruitingNCT06259864Not applicable1 country
- Local Vibration for Drooling in Children With Cerebral PalsyCompletedNCT07626424Not applicable1 country
- A Retrospective Chart Abstraction to Investigate the Prevalence of Chronic Sialorrhea, and the Real-world Use of incobotulinumtoxinA Injections in Male and Female Participants Aged 18 Years and Older With Chronic SialorrheaCompletedNCT078814971 country
- Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s DiseaseActive, not recruitingNCT07588191Not applicable1 country
- Cognitive-Integrated Soccer Training and PerformanceCompletedNCT07284940Not applicable1 country
- A Clinical Study of Ultrasound-guided Botulinum Toxin A Into Salivary Gland for Sialorrhea After True Bulbar PalsyWithdrawnNCT07070817Not applicable1 country
- Post-Covid-19 Patients Follow-up StudyCompletedNCT07571382Not applicable1 country
- Efficacy and Safety Study of MYOBLOC® in the Treatment of Sialorrhea in Adult SubjectsCompletedNCT01994109Phase 33 countries
- Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in AdultsCompletedNCT02610868Phase 33 countries
- A Multi-Center Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease PatientsCompletedNCT00515437Phase 21 country
- Effect of SCS Technique on Oromotor Skills in Children With CPActive, not recruitingNCT07516860Not applicable1 country
- Botulinum Toxin Injections Into the Salivary Glands of Cerebrospinal Children With Chronic SialorrheaCompletedNCT070677621 country
- The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General AnesthesiaWithdrawnNCT06967064Phase 4
- Pharmacokinetics of Atropine Oral GelCompletedNCT05164367Early Phase 11 country
- Efficacy and Safety Study of MYOBLOC in the Treatment of Sialorrhea in Pediatric SubjectsWithdrawnNCT05097079Phase 3
- Oral Care of Intubated Intensive Care PatientCompletedNCT06258603Not applicable1 country
- Botulinum Toxin Injection for Sialorrhea in Cerebral PalsyCompletedNCT061011601 country
- STN-DBS and the Risk of SialorrheaCompletedNCT06090929Not applicable1 country
- A Relative Efficacy and Safety Study of OC Oral Solution for Sialorrhoea in Patients With Parkinson's DiseaseCompletedNCT01370811Phase 21 country
- Prevalence of Sialorrhea in Patients Treated With ClozapineCompletedNCT041970371 country
- Kinesio Taping Versus Oromotor Training on Drooling in Children With Spastic Cerebral PalsyCompletedNCT05524831Not applicable1 country
- Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,Status unknownNCT04873115Phase 41 country
- Effects of Open and Closed System Suctioning on Suctioning Frequency and Amount of SecretionCompletedNCT04053751Not applicable1 country
- Safety and Efficacy of Cryoablation in Management of Sialorrhea in Patients With Neurological DisordersWithdrawnNCT03704168Not applicable
- Excessive Crying in Children With Cerebral Palsy and Communication DeficitsCompletedNCT04523935Phase 4
- Effectiveness of Kinesiotaping and Manipulation Therapies in Drooling Management Among Children With Oral DysphagiaStatus unknownNCT04266626Not applicable1 country
- Acute Salivary Flow Rate Response to Transcutaneous Electrical Nerve Stimulation Versus Electro-acupunctureStatus unknownNCT042113241 country
- Turkish Validation of The Drooling Impact ScaleStatus unknownNCT041327651 country
- Validation of the French Version of the Drooling Impact Scale in a Pediatric Cerebral Palsy PopulationCompletedNCT039863331 country
- Ipratropium Bromide Spray as Treatment for Sialorrhea in ChildrenStatus unknownNCT03747536Phase 2
- Pilot Study of DRibble Vaccine for Prostate Cancer PatientsCompletedNCT02234921Phase 11 country
- Study of Glycopyrrolate for Moderate-to-severe Sialorrhea in Parkinson's DiseaseStatus unknownNCT02382198Phase 21 country
- Clozapine-induced Hypersalivation - Feasibility TrialCompletedNCT02613494Phase 1/21 country
- Ipratropium Spray for Drooling Saliva in Parkinson's DiseaseCompletedNCT00296946Phase 21 country
- Effect of Functional Chewing Training on Tongue Thrust and Drooling in Children With Cerebral PalsyCompletedNCT03194048Not applicable
- Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease (PD)/ParkinsonismCompletedNCT01653132Phase 21 country
- The Treatment of Advanced Lung Cancer With Dribbles Antigen by Targeting Activation of TcellsStatus unknownNCT03057340Phase 1
- Management of Drooling in Children With Cerebral Palsy in FranceCompletedNCT02797106
- Study of the Safety and Efficacy of Tropicamide Thin Films to Reduce Hypersalivation in Parkinson's PatientsCompletedNCT01844648Phase 21 country
- Safety and Efficacy Study of NH004 Films for Relief of Sialorrhea Symptoms in Parkinson's Disease PatientsCompletedNCT00761137Phase 21 country
- Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related SialorrheaCompletedNCT01551940Phase 21 country
- Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological DiseasesCompletedNCT02425176Phase 2/31 country
- Oral Health Literacy Tailored CommunicationCompletedNCT01118143Not applicable1 country
- Metoclopramide as Treatment of Clozapine-induced HypersalivationCompletedNCT02222220Phase 31 country
- Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ketamine SedationCompletedNCT01191398Not applicable1 country
- Efficacy of Intravenous Glyco-P® in Patients Undergoing Procedure That Require Anesthesia ServiceCompletedNCT021025421 country