Sciatica clinical trials
The registry lists 149 studies for Sciatica across more than 10 countries. 31 are recruiting or about to start. 86 of them are mainly about Sciatica (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Riphah International University (7) · Jaseng Medical Foundation (6) · Biogen (4) · Johns Hopkins University (4) · Kaiser Permanente (3) · Cairo University (3) · National Institute of Dental and Craniofacial Research (NIDCR) (3) · University of Lahore (3)
What is being tested here
Drugs under test in Sciatica studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Corticosteroids 3 open · Opioids 6 · NSAIDs 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE · National University of Natural Medicine
- Dec 2026Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg Pain · Universidad Complutense de Madrid
- Dec 2026Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care · University of California, San Francisco
- Jan 2027Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Related Leg Pain · Universidad Complutense de Madrid
- Jan 2027Effect of Sensorimotor Training on Pain and Gait Performance in Patients With Discogenic Sciatica · Cairo University
- Jan 2027Brain Mechanisms Supporting Cannabis-induced Pain Relief · University of California, San Diego
- Jan 2027Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica · Cairo University
- Feb 2027Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial · Shanghai Yueyang Integrated Medicine Hospital
- May 2027Dose Dependent Steroid Injections · University of Miami
- May 2027Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal Stenosis · Assiut University
Who these studies take
Of the 18 Sciatica studies recruiting now, 5 (28%) set no upper age limit and 12 (67%) stop at 75 or younger. 1 (6%) take children under 18. 0 (0%) are for women only and 2 (11%) for men only; 2 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (6%) | 1 (6%) |
| 18 | 10 (56%) | 11 (61%) |
| 30 | 15 (83%) | 16 (89%) |
| 40 | 16 (89%) | 17 (94%) |
| 50 | 16 (89%) | 17 (94%) |
| 65 | 11 (61%) | 11 (61%) |
| 75 | 7 (39%) | 7 (39%) |
| 85 | 5 (28%) | 5 (28%) |
Across all 149 studies, recruiting or not: 60% stop at 75 or younger and 35% at 65; 6% take children; 1% are for women only and 2% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sciatica studies take
Of 44 interventional studies with no phase under Sciatica, half reached primary completion within 11 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 11 mo6–30 · 44 studies | — | 11 mo6–30 · 44 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc HerniationOct 26, 2026NCT07895589
Studies
Recruiting first, then most recently updated. Showing 50 of 149. Browse all 149 → or search them.
- Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic SciaticaRecruitingNCT07841405Not applicable1 country
- Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc HerniationNot yet recruitingNCT07895589Not applicable1 country
- Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral RadiculopathyRecruitingNCT07264270Phase 12 countries
- Effect of Sensorimotor Training on Pain and Gait Performance in Patients With Discogenic SciaticaRecruitingNCT07805265Not applicable1 country
- Randomized Evaluation of Lumbar Injection Effectiveness and FunctionNot yet recruitingNCT07856810Not applicable
- Hypersound Treatment for Chronic Neuropathic and Radicular PainNot yet recruitingNCT07831447Not applicable1 country
- Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2Not yet recruitingNCT07579351Phase 3
- A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORERecruitingNCT07125027Not applicable1 country
- Procedural Framing and Epidural Steroid Injection OutcomesRecruitingNCT07498140Not applicable3 countries
- Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)RecruitingNCT07762170Phase 41 country
- Dose Dependent Steroid InjectionsNot yet recruitingNCT07494136Phase 41 country
- Effect of Somatosensory Motor Control With and Without Kinesio Tape in Patients With SciaticaRecruitingNCT07756905Not applicable1 country
- Three CT Signs of Nerve-root Suffering in Low-back Sciatica: a Study of Their Frequency in Patients Referred for CT-guided Nerve-root Infiltration.RecruitingNCT076904491 country
- Comparing Two Soft Tissues Technique on Piriformis Syndrome PatientsNot yet recruitingNCT07661485Not applicable1 country
- Comparing the Effectiveness of Tensioner Vs Slider Neurodynamic Techniques in Patients With SciaticaRecruitingNCT07632612Not applicable1 country
- Brain Mechanisms Supporting Cannabis-induced Pain ReliefRecruitingNCT04982965Early Phase 11 country
- Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard CareRecruitingNCT07397117Not applicable1 country
- FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc HerniationRecruitingNCT07418944Not applicable1 country
- Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg PainRecruitingNCT07377357Not applicable1 country
- Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Related Leg PainRecruitingNCT07373808Not applicable1 country
- Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled TrialNot yet recruitingNCT07576348Not applicable
- Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar RadiculopathyNot yet recruitingNCT07558993Not applicable1 country
- Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal StenosisNot yet recruitingNCT07542054Not applicable
- Diagnostic Accuracy of Clinical Tests and Diagnostic Criteria for Piriformis SyndromeNot yet recruitingNCT07473349Not applicable1 country
- The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment SuccessNot yet recruitingNCT073671911 country
- Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid InjectionNot yet recruitingNCT070803071 country
- Comparing the Efficacy of Steroid, Acupuncture and Platelet Rich Plasma Injection in Patients with SciaticaRecruitingNCT03801512Not applicable1 country
- Effects of SSMC With and Without Myofascial Release in Patients With SciaticaRecruitingNCT06696898Not applicable1 country
- Effects of Myofacial Release Technique and Sciatic Nerve Slider Technique in SciaticaRecruitingNCT06536829Not applicable1 country
- Transforaminal Epidural Injection in Acute SciaticaRecruitingNCT03924791Not applicable1 country
- Effect of Shockwave Therapy on Post-laminectomy Fibrosis Low Back Pain Patients.Not yet recruitingNCT05887024Not applicable
- Ultrasonographic Evaluation of the Sciatic Nerve in Patients With Piriformis SyndromeCompletedNCT067834391 country
- Two-leg Rotation and SciaticaCompletedNCT07444125Not applicable1 country
- Effects of Shockwave Therapy Versus Ultrasound Therapy Among Patients With Chronic SciaticaCompletedNCT07710924Not applicable1 country
- Intravascular Laser and Electroacupuncture for Sciatica With Insomnia: A Pilot TrialCompletedNCT06755593Not applicable1 country
- Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc ReplacementCompletedNCT069896321 country
- Ultrasound-guided Transgluteal Sciatic Nerve Hydrodissection for the Treatment of Sciatica in the Emergency DepartmentCompletedNCT07588126Not applicable1 country
- Comparative Effects of Dynamic Stretching Versus Slider Neurodynamic Technique In Patients With Lumbar RadiculopathyCompletedNCT07384832Not applicable1 country
- Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain ReliefCompletedNCT06947785Not applicable1 country
- Neurodynamic Moblization Versus Mulligan on Pain and Functional Abilities in Patients With Chronic Discogenic SciaticaCompletedNCT07050108Not applicable1 country
- Lumbar Spinal Fibrosis and TNF Alpha InhibitionCompletedNCT00385086Phase 31 country
- Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/SpondylolisthesisActive, not recruitingNCT038794471 country
- Effect of Neurodynamic Mobilization in Patients With Lumbar Disc HerniationCompletedNCT07203560Not applicable1 country
- Spine Registration Using 3D Scanning - AriseTerminatedNCT051955931 country
- The Effect of High-power Laser Therapy on Pain, Functional Disability, Range of Motion and Pressure Pain Threshold in Subjects With Radicular Low Back Pain Due to Intervertebral Disc HerniationCompletedNCT06151704Not applicable1 country
- SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)CompletedNCT03607838Phase 31 country
- Pentoxifylline and Lumbar RadiculopathyActive, not recruitingNCT03060434Phase 41 country
- The Effect of Early MSAT Treatment on Sciatica Caused by Traffic Accidents.CompletedNCT06179901Not applicable1 country
- Comparative Effects of Sciatic Nerve Flossing and Active Release Technique in Cyclists With SciaticaActive, not recruitingNCT06827574Not applicable1 country
- Non-surgical Spinal Decompression in Patients with Chronic Low Back PainCompletedNCT06275750Not applicable1 country