An interventional study of Combined Neural Mobilization with Manual myofascial Release and Neural Mobilization in Sciatica, sponsored by Riphah International University. Completed at 1 site in Pakistan. Open to participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-04-08.
Sponsored by Riphah International University · Not applicable, Interventional, and Treatment
This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness, mechanisms, and practical considerations associated with these interventions, ultimately contributing to evidence based and patient centered care.
MFR is a hands-on technique targeting fascial restrictions that may contribute to pain and reduced mobility. Barnes proposed that releasing fascial adhesions can improve circulation, reduce nerve compression, and enhance tissue flexibility. In a study by Ajimsha et al. , MFR was found to significantly reduce pain and improve physical function in patients with nonspecific low back pain. There is a lack of comparative research assessing the relative efficacy of neural mobilization andMFR in sciatic pain management. While both techniques are rooted in distinct mechanisms neural desensitization versus fascial release they may have overlapping benefits in improving mobility and reducing pain. This study addresses this research gap by directly comparing the two approaches in individuals with sciatic pain.
149 studies on the registry are indexed under Sciatica; 31 are open to participants now.
This study's enrollment of 48 is below the median of 68 across 122 interventional studies indexed under Sciatica.
Browse Sciatica studies →Riphah International University is the lead sponsor of 2,193 studies on the registry; 650 are open to participants now.
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Exclusion Criteria:
- Participants fall in this category would be excluded of the study.
Combined neural mobilization of Sciatic nerve and manual myofascial release of piriformis and back muscles will be given to this group.
Other: Combined Neural Mobilization with Manual myofascial Release
Only neural mobilization of Sciatic nerve will be given to this group.
Other: Neural Mobilization
Only manual myofascial release of piriformis and back muscles will be given to this group.
Other: Manual Myofascial Release
Combined neural mobilization with manual myofascial release will be provided to each subject.
Also known as: Neural Mobilization, Manual Myofascial Release
neural mobilization will be provided to each subject.
Also known as: Combined Neural Mobilization with Manual myofascial Release, Manual Myofascial Release
Manual myofascial release will be provided to each subject.
Also known as: Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization
Numerical pain rating scale
A subjective pain assessment tool where patients rate their pain intensity on a scale from 0 (no pain) to 10 (worst imaginable pain).
Time frame: Four Weeks
Universal Goniometer
Joint range of motion will be measured using a Universal Goniometer in degrees (°). Each joint movement will be assessed individually. The goniometer will be used following standardized procedures as per the American Academy of Orthopaedic Surgeons (AAOS) guidelines. Unit of Measure is degrees.
Time frame: Four Weeks
Patient-Specific Functional Scale
The Patient-Specific Functional Scale is a validated patient-reported outcome measure used to assess functional limitations based on activities identified by the patient. Participants will rate their ability to perform 3-5 self-selected activities that are important to them, using an 11-point scale ranging from 0 to 10. Minimum score: 0 (indicating the patient is unable to perform the activity) Maximum score: 10 (indicating the patient can perform the activity at their prior level with no difficulty) Interpretation: Higher scores indicate better functional status. The average score across all selected activities will be used for analysis.
Time frame: Four Weeks
SLR (Straight Leg Raise)
A clinical test used to assess sciatic nerve irritation or lumbar radiculopathy by raising the extended leg while the patient lies supine.
Time frame: Four Weeks
Plan to share: No
No publications or documents are linked to this record.
Ran from Apr 2025 to primary completion in Oct 2025, 5 months.
Of 44 non-industry interventional studies with no phase under Sciatica, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 30. This study's 5 months is below that.
Counting every sponsor, half of 44 studies reached it within 11 months; a quarter within 6 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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