Rheumatic Heart Disease clinical trials

The registry lists 61 studies for Rheumatic Heart Disease across more than 10 countries. 25 are recruiting or about to start. 51 of them are mainly about Rheumatic Heart Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Status

Completed: 22
Not yet recruiting: 14
Recruiting: 11
Status unknown: 8
Active, not recruiting: 3
Withdrawn: 1

Phase

Phase 3: 9
Phase 2: 6
Phase 1: 2

Where

Uganda: 15
Nepal: 8
China: 6
Zambia: 5
Brazil: 3
Ethiopia: 3

Who runs them

Children's Hospital Medical Center, Cincinnati (13) · Insel Gruppe AG, University Hospital Bern (3) · University of Washington (2) · Assiut University (2) · Population Health Research Institute (2) · Sun Yat-sen University (2) · Centre for Infectious Disease Research in Zambia (2) · Thomas Pilgrim (2)

What is being tested here

Drugs under test in Rheumatic Heart Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Penicillin V	1	1	2
Hydroxychloroquine	1	1	1
Prednisone	1	1	1
Prednisolone	1	1	1
Rivaroxaban	0	3	3
Glutamine	0	0	1
Simvastatin	0	0	1
Dapagliflozin	0	1	1
Thymalfasin	0	0	1
Ramipril	0	1	1

Coming up

3phase 3 studies under way

4studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 4

Jan 2027Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda · Children's Hospital Medical Center, Cincinnati
Sep 2027Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status · Ahmed Hassan Rostom Ibrahim
Sep 2027Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System · Centre for Infectious Disease Research in Zambia
Oct 2027Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor · University of Sao Paulo General Hospital

Who these studies take

Of the 11 Rheumatic Heart Disease studies recruiting now, 5 (45%) set no upper age limit and 5 (45%) stop at 75 or younger. 8 (73%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (36%) take healthy volunteers.

Recruiting studies that take each age, of 11
Age	Women	Men
10	7 (64%)	7 (64%)
18	7 (64%)	7 (64%)
30	7 (64%)	7 (64%)
40	6 (55%)	6 (55%)
50	6 (55%)	6 (55%)
65	6 (55%)	6 (55%)
75	6 (55%)	6 (55%)
85	5 (45%)	5 (45%)

Across all 61 studies, recruiting or not: 49% stop at 75 or younger and 44% at 65; 69% take children; 3% are for women only and 0% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting1

Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world PracticeOct 30, 2026NCT07068633

Newly registered2

Studies

Recruiting first, then most recently updated. Showing 50 of 61. Browse all 61 → or search them.