An interventional study of Case Management Supports in Rheumatic Heart Disease in Children and Heart Disease, Valvular, sponsored by Children's Hospital Medical Center, Cincinnati. Completed at 1 site in Uganda. Open to participants aged 5 Years to 20 Years. Per ClinicalTrials.gov, last updated 2026-05-28.
Sponsored by Children's Hospital Medical Center, Cincinnati · Not applicable, Interventional, and Supportive care
CAMPS Plus is a non-randomized extension cohort to assess the non-inferiority of a case manager only (CM) intervention when compared to case manager plus peer support group (CM+PG) to support secondary antibiotic prophylaxis (SAP) adherence in children with RHD
The objective of CAMPS Plus is to determine the minimum intervention needed to achieve secondary antibiotic prophylaxis (SAP) adherence for children newly diagnosed with rheumatic heart disease to further increase affordability and feasibility at scale.
Aim 1: Determine the difference in 1-year SAP adherence rates of children newly diagnosed with RHD in Uganda receiving one of two support strategies: case manager only (CM) and case manager plus peer support group (CM + PG).
Aim 2: Explore implementation determinants among case managers, participants, and participant families to inform deployment of program at scale.
535 studies on the registry are indexed under Heart Valve Diseases; 173 are open to participants now.
This study's enrollment of 335 is above the median of 100 across 291 interventional studies indexed under Heart Valve Diseases.
Browse Heart Valve Diseases studies →Children's Hospital Medical Center, Cincinnati is the lead sponsor of 661 studies on the registry; 134 are open to participants now.
Of its 54 completed or terminated interventional studies of FDA-regulated products, 30 (56%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
For this study, ALL participants will be assigned the same prophylaxis support strategy which consists of a calendar of injection dates plus assignment of a case manager who sends weekly text messages, reminder calls prior to scheduled penicillin injections, and home visits as needed. There will be 3 different cohorts based on their prior experience with prophylaxis supports as follows: Cohort 1: Children 5-20 years old that participated in the CAMPS trial between August 2022 and August 2023 and were randomized to enhanced supports (case manager plus peer group, CM+PG) intervention Cohort 2: Children 5-20 years old that participated in the CAMPS trial between August 2022 and August 2023 and were randomized to standard care (injection tracking booklet and referral to health center) intervention. Cohort 3: A prospectively recruited cohort drawn from school-based echocardiography screening who are generally comparable in age and sex distribution to the original CAMPS trial
Behavioral: Case Management Supports
Participants will be assigned a community case manager who will provide case management support which will include a calendar of injection dates, weekly text messages, reminder call prior to scheduled penicillin injections, and home visits as needed
Percent Secondary Antibiotic Prophylaxis Adherence
continuous measure of days of antibiotic coverage, assuming one injection provides coverage for 28 days
Time frame: 12 months
Plan to share: Undecided — Only deidentified information would be shared
No publications or documents are linked to this record.
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Children's Hospital Medical Center, Cincinnati