Obesity Hypoventilation Syndrome clinical trials
The registry lists 73 studies for Obesity Hypoventilation Syndrome across more than 10 countries. 10 are recruiting or about to start. 54 of them are mainly about Obesity Hypoventilation Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Guy's and St Thomas' NHS Foundation Trust (5) · Fisher and Paykel Healthcare (5) · Istanbul University (4) · ResMed (4) · Assiut University (3) · Wissenschaftliches Institut Bethanien e.V (3) · Sociedad Española de Neumología y Cirugía Torácica (2) · University Hospital, Geneva (2)
Who these studies take
Of the 5 Obesity Hypoventilation Syndrome studies recruiting now, 4 (80%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (40%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 4 (80%) | 4 (80%) |
Across all 73 studies, recruiting or not: 22% stop at 75 or younger and 7% at 65; 5% take children; 0% are for women only and 0% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Obesity Hypoventilation Syndrome studies take
Of 17 interventional studies with no phase under Obesity Hypoventilation Syndrome, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 31 mo20–44 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Newly registered1
- Oxytocin for Respiratory Compromise and Hypoventilation Induced by DrugsOct 29, 2026NCT07902752
Studies
Recruiting first, then most recently updated. Showing 50 of 73. Browse all 73 → or search them.
- Oxytocin for Respiratory Compromise and Hypoventilation Induced by DrugsNot yet recruitingNCT07902752Phase 2
- Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep ApneaNot yet recruitingNCT07809061Not applicable1 country
- The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory DiseaseRecruitingNCT070600791 country
- The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study.Not yet recruitingNCT06972589Not applicable1 country
- Assessment of Breathing Pattern During NIVRecruitingNCT06682286Not applicable1 country
- Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome PatientsNot yet recruitingNCT067661101 country
- Comfort of Patients Under Non Invasive Ventilation According to the MaskNot yet recruitingNCT062121801 country
- Respiratory Muscle Strength in Patients With Obesity Hypoventilation Syndrome (OHS) or With a Precursor of the DiseaseRecruitingNCT038540581 country
- Obesity-hypoventilation in Metabolic Syndrom PatientsRecruitingNCT048394191 country
- Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care PatientsRecruitingNCT06090149Not applicable1 country
- Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation SyndromeCompletedNCT071471531 country
- Detecting Systemic Carbon Dioxide Levels With a Novel BiosensorCompletedNCT063676861 country
- Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive VentilationCompletedNCT06560411Not applicable1 country
- The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese IndividualsCompletedNCT061425131 country
- Effects of Exercise Training on Exercise Capacity and Sleep Quality in Patients With Obesity Hypoventilation SyndromeCompletedNCT05398068Not applicable1 country
- Transdisciplinary Intervention for Obesity Hypoventilation SyndromeCompletedNCT070206891 country
- A Non-Interventional Pilot Study to Explore the Role of Gut Flora in ObesityWithdrawnNCT041006161 country
- Euthyroid Sick Syndrome in Obesity Hypoventilation SyndromeCompletedNCT069834181 country
- Evaluation of An Optical Measurement Algorithm Combined With Patient and Provider Input to Reduce Mask Exchanges During Initial Positive Airway Pressure TherapyCompletedNCT046881251 country
- Study of AD981 Versus Placebo in Obesity Hypoventilation SyndromeCompletedNCT05448443Phase 21 country
- The Effect of Sarcopenic Obesity on Sleep in Individuals With Obesity Hypoventilation SyndromeStatus unknownNCT061365331 country
- Myocardial Effects of NIV in OHS PatientsCompletedNCT06486129Not applicable1 country
- Remote Monitoring to Improve Low Adherence in Non-invasive VentilationCompletedNCT04884165Not applicable1 country
- Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation SyndromeCompletedNCT06442163Not applicable1 country
- Response to NonInvasive Mechanical Ventilation According to the Breathing PatternWithdrawnNCT01991535Not applicable1 country
- Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United KingdomActive, not recruitingNCT05167201Not applicable1 country
- Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation SyndromeCompletedNCT04327336Not applicable1 country
- Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES Program) Compared to Standard of Care in Patients With Chronic Respiratory Failure Receiving Non-invasive Home VentilationCompletedNCT04615078Not applicable1 country
- "Post-acute Pickwick Study" (Postacute-Pick-2020)WithdrawnNCT04317326Not applicable
- HVNI Versus NIV In Management Of Acute Hypercapnic Respiratory Failure In OHSStatus unknownNCT05805293Not applicable
- Pathophysiology of Hypoventilation in Obesity and Effects of Bariatric InterventionStatus unknownNCT040255281 country
- Medico-economics and QoL of Obese Patients Followed by Medical Analysis Laboratories (BIOSAOS )WithdrawnNCT03861468Not applicable1 country
- Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap SyndromeStatus unknownNCT05190458Not applicable1 country
- Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -TerminatedNCT02021448Not applicable1 country
- Ketogenic Diet for Obesity Hypoventilation SyndromeCompletedNCT04108819Not applicable1 country
- Toffee Full Face and Toffee Nasal Mask Evaluation in Obesity Hypoventilation Syndrome (NZ)TerminatedNCT02486380Not applicable1 country
- Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis PlatformCompletedNCT030855371 country
- Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory DiseasesStatus unknownNCT040980941 country
- Resting Energy Expenditure in Patients With OHS Treated With Long-term NIVSuspendedNCT044745871 country
- A Study to Investigate the Effects of Heated Humidification During Non-Invasive VentilationCompletedNCT01372072Not applicable1 country
- The Debated Role of Sleep Studies in Patients Under Established Home Mechanical VentilationCompletedNCT03506906Not applicable1 country
- Juno Perth Clinical TrialTerminatedNCT02317042Not applicable1 country
- Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory FailureWithdrawnNCT01174316Not applicable1 country
- Respiratory Muscle Endurance in Obesity Hypoventilation SyndromeCompletedNCT048355581 country
- Prevalence Rate, and Clinical Characteristics of Obesity Hypoventilation Syndrome Via Screening Patients Admitted to Medical Intensive Care UnitsCompletedNCT029345811 country
- Usefulness of Transcutaneous Capnography to Assess Residual Hypoventilation in Obesity-Hypoventilation Syndrom Treated by Non Invasive Ventilation at Home : a Prospective StudyCompletedNCT035727121 country
- Effects of PEEP on Heart and Lungs in Obese SubjectsStatus unknownNCT02523352Not applicable1 country
- Obesity in Sleep Medicine - Focusing on OHS PhenotypesCompletedNCT045705401 country
- European Home Mechanical Ventilation RegistryTerminatedNCT023153391 country
- Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory FailureCompletedNCT02342899Phase 32 countries