Pyelonephritis clinical trials
The registry lists 79 studies for Pyelonephritis across more than 10 countries. 12 are recruiting or about to start. 48 of them are mainly about Pyelonephritis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Assistance Publique - Hôpitaux de Paris (10) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · Wockhardt (3) · Merck Sharp & Dohme LLC (3) · IRCCS Burlo Garofolo (2) · Meiji Seika Pharma Co., Ltd. (2) · Shahid Beheshti University (2) · Pfizer (2)
What is being tested here
Drugs under test in Pyelonephritis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lurasidone | 1 | 0 | 1 |
| Cefuroxime axetil | 1 | 0 | 1 |
| Ceftolozane | 0 | 1 | 3 |
| Levofloxacin | 0 | 2 | 3 |
| Doripenem | 0 | 2 | 2 |
| Ciprofloxacin | 0 | 0 | 1 |
| Amdinocillin Pivoxil | 0 | 0 | 1 |
| Relebactam | 0 | 0 | 1 |
| Plazomicin | 0 | 0 | 1 |
| Finafloxacin | 0 | 0 | 1 |
Drug classes tested here Beta-lactamase inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- Mar 2027Efficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients, a Multicentre Randomized Non-inferiority Trial. · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Jan 2027A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Meropenem-Vaborbactam in Children With Complicated Urinary Tract Infection, Including Acute Pyelonephritis · Rempex (a wholly owned subsidiary of Melinta Therapeutics, LLC)
- Apr 2027Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study · True Bearing Diagnostics, Inc.
- Sep 2027Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in Children · Assistance Publique - Hôpitaux de Paris
- Sep 2027This is a Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ertapenem-zidebactam Versus Ceftazidime-Avibactam in the Treatment of Hospitalized Adult Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis · Wockhardt
Who these studies take
Of the 6 Pyelonephritis studies recruiting now, 2 (33%) set no upper age limit and 4 (67%) stop at 75 or younger. 4 (67%) take children under 18. 1 (17%) are for women only and 0 (0%) for men only; 1 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (50%) | 3 (50%) |
| 18 | 4 (67%) | 3 (50%) |
| 30 | 3 (50%) | 2 (33%) |
| 40 | 3 (50%) | 2 (33%) |
| 50 | 2 (33%) | 2 (33%) |
| 65 | 2 (33%) | 2 (33%) |
| 75 | 2 (33%) | 2 (33%) |
| 85 | 2 (33%) | 2 (33%) |
Across all 79 studies, recruiting or not: 35% stop at 75 or younger and 32% at 65; 29% take children; 15% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Studies
Recruiting first, then most recently updated. Showing 50 of 79. Browse all 79 → or search them.
- Fosfomycin Trometamol Compared With an Alternative Active Antibiotic as Step-down Therapy for the Treatment of Acute Pyelonephritis Due to Escherichia Coli in Elderly Women : a Randomized, Multicenter, Non-inferiority TrialNot yet recruitingNCT07928063Phase 3
- Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in ChildrenRecruitingNCT070701021 country
- This is a Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ertapenem-zidebactam Versus Ceftazidime-Avibactam in the Treatment of Hospitalized Adult Patients With Complicated Urinary Tract Infection or Acute PyelonephritisNot yet recruitingNCT07840105Phase 21 country
- Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL StudyRecruitingNCT075793121 country
- 3-day IV Antibiotic Treatment Versus 3-day IV Followed by 7-day Oral Antibiotic Treatment for AP in ChildrenRecruitingNCT05544565Phase 41 country
- Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with PyelonephritisRecruitingNCT06527560Phase 41 country
- Efficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients, a Multicentre Randomized Non-inferiority Trial.RecruitingNCT05597540Phase 31 country
- The Validity of the Quick Renal MRI in Pediatric Kidney DiseaseRecruitingNCT03959163Not applicable1 country
- A Trial of Intravenous HRS-8427 in the Treatment of Adults With Complicate Urinary Tract Infection, Including Acute PyelonephritisNot yet recruitingNCT06144060Phase 2
- NRX-101 for Complicated Urinary Tract Infection (UTI) Including PyelonephritisNot yet recruitingNCT06128213Phase 2
- Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)Not yet recruitingNCT03630081Phase 3
- Evaluation of the Efficacy and Safety of Intravenous Imipenem/Cilastatin/XNW4107 in Comparison With Meropenem in Hospitalized Adults With cUTI Including AP (EudraCT no. 2022-000061-40)Not yet recruitingNCT05204368Phase 31 country
- A Trial of HRS-8427 in the Treatment of Adults With Complicated Urinary Tract Infection, Including Acute PyelonephritisCompletedNCT06569056Phase 31 country
- A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Meropenem-Vaborbactam in Children With Complicated Urinary Tract Infection, Including Acute PyelonephritisActive, not recruitingNCT06672978Phase 26 countries
- Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in WomenCompletedNCT01390623Phase 41 country
- Patient-Directed Antimicrobial Duration in Acute Uncomplicated PyelonephritisCompletedNCT06127160Phase 41 country
- Study of Cefepime-zidebactam (FEP-ZID) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)CompletedNCT04979806Phase 39 countries
- Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)CompletedNCT06526884Not applicable1 country
- P3 Study to Assess Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy for Adults With Infection Due to Carbapenem Resistant EnterobacteralesCompletedNCT05905055Phase 314 countries
- Factors and Prognosis of Obstructive Pyelonephritis PatientsCompletedNCT062992151 country
- Efficacy and Safety of Cefepime/Nacubactam or Aztreonam/Nacubactam Compared to Imipenem/Cilastatin in Subjects With Complicated Urinary Tract Infections or Acute Uncomplicated PyelonephritisCompletedNCT05887908Phase 39 countries
- Plasma NGAL in APN PatientsCompletedNCT068027961 country
- Expanded Access Use of Sulopenem Etzadroxil/Probenecid for Complicated Urinary Tract InfectionNo longer availableNCT04682834
- Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by UrolithiasisCompletedNCT04594161Not applicable1 country
- Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community PyelonephritisCompletedNCT03179384Phase 41 country
- Pharmacokinetics of Ciprofloxacin in Pediatric PatientsCompletedNCT02598362Phase 41 country
- MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)CompletedNCT03230838Phase 210 countries
- Antibiotic Education for Children in an Emergency Care UnitCompletedNCT00948779Not applicable1 country
- Bacterial Metallophores in the Diagnosis of Acute PyelonephritisStatus unknownNCT056740321 country
- Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)CompletedNCT03788967Phase 315 countries
- Cranberry-lingonberry Juice Started During Acute Infection in Prevention of Urinary Tract Infections in ChildrenCompletedNCT01861353Not applicable1 country
- Meropenem-FL058 Phase 2 Study in the Treatment of Complicated Urinary Tract InfectionsStatus unknownNCT05060419Phase 2
- Cefuroxime Resistance in PyelonephritisCompletedNCT046163521 country
- Dexamethasone Administration in 1st Episode of Febrile Urinary Tract InfectionCompletedNCT020348511 country
- Proteinuria During Acute Pyelonephritis In PregnancyCompletedNCT025366381 country
- A Study to Assess Efficacy and Safety Intravenous Benapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)CompletedNCT04505683Phase 2/31 country
- IV or IV/PO Omadacycline vs. IV/PO Levofloxacin for the Treatment of Acute PyelonephritisCompletedNCT03757234Phase 24 countries
- Treating Pyelonephritis an Urosepsis With PivmecillinamCompletedNCT03282006Phase 41 country
- Management of Sub-Clinical Bacteriuria in PregnancyCompletedNCT03275623Phase 41 country
- Special Drug Use Investigation of Ciproxan Injection in PediatricsCompletedNCT025550591 country
- Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract InfectionsCompletedNCT03445195Phase 21 country
- CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative BacteriaCompletedNCT03477422Phase 31 country
- Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)CompletedNCT01505634Phase 2
- Bedside Ultrasonography in Acute Patients With Suspected Kidney InvolvementCompletedNCT038737011 country
- Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP InfectionsCompletedNCT02753946Phase 2/316 countries
- Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)CompletedNCT02728089Phase 3
- Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including PyelonephritisCompletedNCT01345929Phase 317 countries
- Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract InfectionsCompletedNCT00921024Phase 23 countries
- A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP)CompletedNCT01096849Phase 2
- Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and APCompletedNCT02166476Phase 317 countries