An interventional study of Cranberry-lingonberry juice and Placebo juice in Urinary Tract Infection, Pyelonephritis and Cystitis, sponsored by University of Oulu. Completed at 1 site in Finland. Open to participants aged 1 Year to 16 Years. Per ClinicalTrials.gov, last updated 2022-05-09.
Sponsored by University of Oulu · Not applicable, Interventional, and Prevention
Cranberry and cranberry-lingonberry juice prevented urinary tract infections in children and in adults in our earlier clinical trials. The preventive effect was, however, observed late in the follow-up and the next recurrence was not prevented in children. The investigators hypothesize that cranberry-lingonberry juice should be started already during the antimicrobial treatment of acute urinary tract infection in order to maximize the preventive efficacy of the juice. In addition, the investigators aim to find the explanation for the efficacy of cranberry-lingonberry juice by analyzing the concomitant changes in the chemical composition of urine and feces as well as the changes of gut microbiota.
803 studies on the registry are indexed under Urinary Tract Infections; 133 are open to participants now.
This study's enrollment of 113 is below the median of 131 across 560 interventional studies indexed under Urinary Tract Infections.
Browse Urinary Tract Infections studies →University of Oulu is the lead sponsor of 141 studies on the registry; 22 are open to participants now.
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Exclusion Criteria:
Cranberry-lingonberry juice. Cranberry 12.8%, Lingonberry 12.4%, together 38g/l, contains added sugars 10g/dL. Dose is 5 mL/kg/day, max. 300 ml/day per day. Juice was manufactured and donated by Eckes-Granini, Finland
Other: Cranberry-lingonberry juice
Contains no cranberry or lingonberry extracts. Added sugars 10g/dL (same as in the active juice group). Contains natural cranberry flavour and red anthocyanin colour. Contains 5.5 g/L citric acid. Has been tested by chemists and does not contains PAC-compounds which are thought to be the main active compound in cranberry juice. Placebo juice was manufactured by Eckes-Granini. Dose is 5 mL/kg/day, max. 300 mL/day.
Other: Placebo juice
Juice iwth similar sugar concentration as cranberry-lingonberry juice but without berry extracts
Change of the intestinal and urinary microbiome
Time frame: 3 months to 12 months
The occurrence of urinary tract infections (infection episodes/person years at risk)
Time frame: 12 months
Time to the first recurrence
Time frame: 6 months
This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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