Psychotic Disorders clinical trials
The registry lists 1,587 studies for Psychotic Disorders across more than 10 countries. 281 are recruiting or about to start. 518 of them are mainly about Psychotic Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 4,592 studies for Psychotic Disorders. How that becomes 1,587 here
This page counts the studies the registry files under Psychotic Disorders, and those it files under no condition that list Psychotic Disordersthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 4,592Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −130List Psychotic Disorders as a condition, but the registry did not file them under itMost often written as “Schizophrenia Spectrum and Other Psychotic Disorders” (25), “Parkinson Disease Psychosis” (12), and “Affective Disorders, Psychotic” (8). The registry filed 31 of them under no condition at all, and the others under other conditions only, most often Schizophrenia (44) and Schizophrenia Spectrum and Other Psychotic Disorders (27).
- −2,875Match it another way117 name it in the title, 26 in a keyword, and 2,732 by a synonym or other text the search reads.
- 1,587The count on this page
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Status
Who runs them
VA Office of Research and Development (40) · Yale University (38) · Centre for Addiction and Mental Health (37) · New York State Psychiatric Institute (25) · King's College London (25) · University of Maryland, Baltimore (24) · University of North Carolina, Chapel Hill (24) · Dartmouth-Hitchcock Medical Center (23)
What is being tested here
Drugs under test in Psychotic Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Clozapine | 5 | 0 | 14 |
| Cannabidiol | 4 | 4 | 11 |
| Acetylcysteine | 3 | 1 | 7 |
| ML-007C | 3 | 0 | 4 |
| Risperidone | 2 | 18 | 66 |
| Aripiprazole | 2 | 11 | 42 |
| Dexmedetomidine | 2 | 2 | 7 |
| Modafinil | 2 | 2 | 6 |
| Xanomeline | 2 | 5 | 5 |
| Trospium | 2 | 3 | 3 |
Drug classes tested here Antipsychotics 11 open · Stimulants 3 open · Antimuscarinics 2 open · Opioid antagonists 1 open · SERMs 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4) · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Dec 2026Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Treatment in Early Psychosis · Phase 3 · University of California, San Diego
- Dec 2026Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms. · Phase 3 · Louisiana State University Health Sciences Center Shreveport
- Dec 2026Efficiency of a Composite Personalised Care on Functional Outcome in Early Psychosis · Phase 3 · Centre Hospitalier St Anne
- Nov 2026Youth Nominated Support Team · University of California, Irvine
- Nov 2026Obstructive Sleep Apnea Treatment in Serious Mental Illness · University of California, San Diego
- Nov 2026Effects of NAC on Symptoms of CHR Patients · Centre for Addiction and Mental Health
- Nov 2026What is the Feasibility of Narrative Exposure Therapy (NET) for People Experiencing Psychosis? · University of Nottingham
- Nov 2026Psychosis TMS Study · Massachusetts General Hospital
- Nov 2026CBT-I to Improve Functional Outcomes in Veterans With Psychosis · VA Office of Research and Development
Who these studies take
Of the 205 Psychotic Disorders studies recruiting now, 53 (26%) set no upper age limit and 143 (70%) stop at 75 or younger. 51 (25%) take children under 18. 2 (1%) are for women only and 1 (<1%) for men only; 41 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 10 (5%) | 10 (5%) |
| 18 | 189 (92%) | 189 (92%) |
| 30 | 180 (88%) | 180 (88%) |
| 40 | 154 (75%) | 154 (75%) |
| 50 | 138 (67%) | 137 (67%) |
| 65 | 108 (53%) | 108 (53%) |
| 75 | 62 (30%) | 63 (31%) |
| 85 | 59 (29%) | 60 (29%) |
Across all 1,587 studies, recruiting or not: 74% stop at 75 or younger and 68% at 65; 21% take children; 2% are for women only and 1% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Psychotic Disorders studies take
Of 51 phase 4 interventional studies under Psychotic Disorders, half reached primary completion within 58 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 19 mo10–55 · 28 studies | — | — |
| Phase 2 | 39 mo22–53 · 39 studies | — | 49 mo27–53 · 28 studies |
| Phase 3 | 39 mo17–72 · 26 studies | — | — |
| Phase 4 | 58 mo32–71 · 51 studies | — | 60 mo39–71 · 45 studies |
| Interventional, no phase | 34 mo19–52 · 457 studies | — | 34 mo19–52 · 455 studies |
| Observational | 64 mo35–124 · 76 studies | — | 64 mo35–124 · 74 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting3
- Tracking the Linguistic Signatures of Motivational Interviewing in Acute PsychosisNov 10, 2026NCT05911529
- The ATP Project (Antipsychotic-TEP-Psychosis)Oct 26, 2026NCT06651112
- Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for PsychosisOct 22, 2026NCT07756567
Results posted1
- Assessment and Treatment for Chronic Pain in Veterans With Serious Mental IllnessOct 29, 2026NCT04118283
Stopped2
- A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With SchizophreniaWithdrawnOct 30, 2026NCT07084831
- Normobaric Oxygen Therapy for Individuals With First-Episode PsychosisTerminatedOct 16, 2026NCT04368039
Newly registered11
- Pharmacokinetics and Relative Bioavailability of Intranasal vs Intramuscular Olanzapine in Healthy Adult ParticipantsNov 6, 2026NCT07921966
- Theta-Burst Transcranial Magnetic Stimulation for Treatment-Resistant Auditory HallucinationsOct 29, 2026NCT07902518
- Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3Oct 28, 2026NCT07900893
- Reducing Stigma - A Treatment for Early Psychosis to Prevent SuicideOct 27, 2026NCT07898631
- Integrated Psychoeducation Program for Internalized Stigma in SchizophreniaOct 27, 2026NCT07898852
Show 6 moreShow fewer
- Targeted Health Dialogues for Individuals With Psychosis Spectrum DisordersOct 22, 2026NCT07888894
- French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy ControlsOct 19, 2026NCT07881016
- Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental IllnessOct 16, 2026NCT07879118
- A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental IllnessOct 16, 2026NCT07879131
- Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2Oct 15, 2026NCT07875790
- Validation and Comparative Multi-Omics Benchmarking of Fluid-Derived Volatilomics Biomarkers for the Prevention and Early Detection of SchizophreniaOct 15, 2026NCT07876089
Studies
Recruiting first, then most recently updated. Showing 50 of 1,587. Browse all 1,587 → or search them.
- Cannabis Potency Effects on Brain White Matter in Early Phase PsychosisNot yet recruitingNCT07001878Phase 41 country
- Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase PsychosisRecruitingNCT07056894Not applicable1 country
- Tracking the Linguistic Signatures of Motivational Interviewing in Acute PsychosisRecruitingNCT05911529Not applicable1 country
- Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1RecruitingNCT07853807Not applicable1 country
- Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3RecruitingNCT07900893Not applicable1 country
- Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2Not yet recruitingNCT07875790Not applicable1 country
- Pharmacokinetics and Relative Bioavailability of Intranasal vs Intramuscular Olanzapine in Healthy Adult ParticipantsNot yet recruitingNCT07921966Phase 1
- REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)RecruitingNCT07006935Not applicable1 country
- A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's DiseaseRecruitingNCT06540833Phase 210 countries
- NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in SchizophreniaNot yet recruitingNCT07788755Not applicable1 country
- Sensory Profile and Early Clinical Signs of Calm Room UsersRecruitingNCT068399501 country
- Magnetic Seizure Therapy for Schizophrenia - TrialRecruitingNCT06672588Not applicable1 country
- Theta-Burst Transcranial Magnetic Stimulation for Treatment-Resistant Auditory HallucinationsRecruitingNCT07902518Not applicable1 country
- Reducing Stigma - A Treatment for Early Psychosis to Prevent SuicideNot yet recruitingNCT07898631Not applicable1 country
- A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)RecruitingNCT06585787Phase 325 countries
- Integrated Psychoeducation Program for Internalized Stigma in SchizophreniaNot yet recruitingNCT07898852Not applicable1 country
- The ATP Project (Antipsychotic-TEP-Psychosis)RecruitingNCT066511121 country
- Supporting Patients by Family Education in Psychotic Illness: A Prospective Cohort StudyRecruitingNCT05500001Not applicable1 country
- Incentives and Long-Acting Injectable Adherence After Involuntary HospitalizationEnrolling by invitationNCT07130500Not applicable1 country
- Targeted Health Dialogues for Individuals With Psychosis Spectrum DisordersNot yet recruitingNCT07888894Not applicable
- Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for PsychosisRecruitingNCT07756567Not applicable1 country
- French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy ControlsRecruitingNCT07881016Not applicable1 country
- Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental IllnessNot yet recruitingNCT07879118Not applicable1 country
- A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental IllnessNot yet recruitingNCT07879131Not applicable1 country
- A Long-Term Open-Label Study of ML-007C-MA in Adults With SchizophreniaRecruitingNCT07459647Phase 21 country
- Evaluation of Step-Based Care for Individuals at Clinical High Risk for PsychosisEnrolling by invitationNCT039700051 country
- Online Intervention To Improve MotivationNot yet recruitingNCT07157293Not applicable1 country
- Feasibility Trial of a Parent Peer-Co-Led Caregiver Group for Pediatric Early Onset Schizophrenia Spectrum DisordersNot yet recruitingNCT07867964Not applicable1 country
- Targeting Emotion Dysregulation to Reduce Suicide in People With PsychosisRecruitingNCT05440214Not applicable1 country
- Stratification and Treatment in Early Psychosis Study - PROMOTENot yet recruitingNCT07434973Phase 310 countries
- Stratification and Treatment in Early Psychosis Study -ASSISTNot yet recruitingNCT07326124Phase 38 countries
- Stratification and Treatment in Early Psychosis Study - ENHANCERecruitingNCT06778564Phase 39 countries
- iTBS to Enhance Social Cognition in People With PsychosisRecruitingNCT06118268Not applicable1 country
- Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar DisorderRecruitingNCT07213492Not applicable1 country
- Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early PsychosisNot yet recruitingNCT07503093Not applicable1 country
- Motivational Intervention for Patients With SchizophreniaNot yet recruitingNCT07853079Not applicable
- A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease PsychosisRecruitingNCT06887192Phase 215 countries
- Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With PsychotherapyRecruitingNCT06835556Not applicable1 country
- Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in SchizophreniaRecruitingNCT07759895Phase 21 country
- A Closed Unit Incorporating Soteria Elements Versus a Conventional Closed Psychiatric WardRecruitingNCT07836348Not applicable1 country
- FEEL-GOOD: A Multicenter Trial of a Mindfulness-Based Group Therapy in Young Adults With Early PsychosisRecruitingNCT07645443Not applicable1 country
- State Representation in Early Psychosis 2RecruitingNCT078342031 country
- A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) InhibitorRecruitingNCT07105111Phase 41 country
- tACS for Self-Other Boundary in SchizophreniaRecruitingNCT07818668Not applicable1 country
- Group Dialectical Behaviour Therapy (DBT) Skills Training for First Episode PsychosisNot yet recruitingNCT07777315Not applicable
- Feasibility and Acceptability of Mobile Mental Health App for SZ and SZANot yet recruitingNCT06474325Not applicable1 country
- Building a Computational Model of Auditory HallucinationsNot yet recruitingNCT07820553
- Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis UseRecruitingNCT05445180Not applicable1 country
- Ultrasound Assessment of Gluteal Muscle in Patients Receiving Depot Antipsychotics and Healthy VolunteersNot yet recruitingNCT07815587
- Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode PsychosisNot yet recruitingNCT07811466Not applicable