Drug
Clozapine clinical trials
Also written Clozaril and Leponex.
- studies test it
- 44
- open now
- 8
- in phase 3
- 7
- first study started
- 1993
Keep track of what changes. Save the Clozapine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Studies by the year they started
43 studies that test it; most in 2015 (5)
| Year | Studies |
|---|---|
| 1993 | 1 |
| 1994 | 1 |
| 1996 | 1 |
| 1997 | 1 |
| 1998 | 1 |
| 1999 | 2 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 2 |
| 2005 | 1 |
| 2006 | 2 |
| 2008 | 2 |
| 2011 | 2 |
| 2012 | 2 |
| 2013 | 1 |
| 2015 | 5 |
| 2016 | 2 |
| 2018 | 1 |
| 2019 | 1 |
| 2020 | 3 |
| 2021 | 2 |
| 2022 | 2 |
| 2023 | 1 |
| 2024 | 2 |
| 2025 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 2
- Phase 2
- 3
- Phase 3
- 7
- Phase 4
- 23
- No phase
- 8
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 4 · Other 40
Shanghai Mental Health Center (4) · Dartmouth-Hitchcock Medical Center (3) · Harvard Medical School (HMS and HSDM) (3) · National Institute of Mental Health (NIMH) (3) · Centre for Addiction and Mental Health (2) · Novartis (2) · Northwell Health (2) · Dr. Inge Winter (2)
Often tested with
Tested in the same studies.
Olanzapine (6) · Risperidone (4) · Amisulpride (4) · Aripiprazole (4) · Valproic Acid (3) · Perphenazine (2) · Haloperidol (2) · Fluvoxamine (2)
Studies
Open first, then newest update. How each study uses Clozapine is read from its arms, and is right about nine times in ten.
Testing it · 44
- Switching From Twice-Daily to Once-Daily Clozapine Dosing in SchizophreniaRecruitingPhase 4Centre for Addiction and Mental HealthNCT02639702Written as Clozapine
- Biomarkers to Enhance Early Schizophrenia TreatmentRecruitingPhase 4Northwell HealthNCT06969755Written as clozapine
- CLOZAPINE Response in Biotype-1RecruitingPhase 4University of Texas Southwestern Medical CenterNCT04580134Written as clozapine
- Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical TrialRecruitingPhase 4New York State Psychiatric InstituteNCT05208190Written as Clozapine
- Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureRecruitingPhase 3Dr. Inge WinterNCT05603104Written as Clozapine
- Biomarkers in Clozapine-responding SchizophreniaRecruitingPhase 4Jimmi NielsenNCT05316883Written as Clozapine
- The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.RecruitingPhase 4Dr. Inge WinterNCT05958875Written as Clozapine
- A Clinical Study of the Safety and Efficacy of Chemogenetics Therapy in the Treatment of Parkinson's DiseaseNot yet recruitingEarly Phase 1Ruijin HospitalNCT07085195Written as clozapine
- An Exploratory Analysis of Immune and Inflammatory Response Associated With ClozapineTerminatedPhase 4Ohio State UniversityNCT05741502Written as Clozapine
- Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT)CompletedPhase 3Shanghai Mental Health CenterNCT03510325Written as Phase 2: Clozapine
- Switching Antipsychotics: Abrupt Discontinuation Versus OverlapCompletedPhase 4Centre for Addiction and Mental HealthNCT02640300Written as Clozapine
- Study to Compare Clozapine vs Treatment as Usual in People With Intellectual Disability & Treatment-resistant PsychosisActive, not recruitingPhase 2Fundación Pública Andaluza para la gestión de la Investigación en SevillaNCT04529226Written as Clozapine
- Bioequivalence Study in Patients With Schizophrenia by Using Clozaril 100 mg Tablet (Clozapine) and WID-CLZ18CompletedPhase 1Whanin Pharmaceutical CompanyNCT04849026Written as Clozaril 100 mg (Clozapine)
- Biomarker and Safety Study of Clozapine in Patients With Benign Ethnic Neutropenia (BEN)CompletedNot applicableUniversity of Maryland, BaltimoreNCT02404155Written as Clozapine
- Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination TherapyCompletedPhase 4Shanghai Mental Health CenterNCT03652974Written as sodium valproate with Clozapine
- Study of the Effect of Dosing on Clozapine LevelsWithdrawnPhase 4University of British ColumbiaNCT02286206Written as Clozapine
- A Long Term Study of Clozapine in Patients With Treatment-resistant SchizophreniaCompletedPhase 2NovartisNCT00154258Written as Clozapine
- SMART Design to Compare Antipsychotic Treatments in Treatment-Resistant SchizophreniaStatus unknownPhase 3Shanghai Mental Health CenterNCT04528095Written as Clozapine
- Clozapine for Cannabis Use in SchizophreniaCompletedPhase 4Dartmouth-Hitchcock Medical CenterNCT01639872Written as Clozapine
- Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use DisorderStatus unknownPhase 4Augusta UniversityNCT03857581Written as Clozapine
See all 44 studies that test Clozapine →
Given in every arm · 6 — Clozapine is usual care beside what is tested
- Pharmacokinetics of Clozapine and Norclozapine and the Effect of PantoprazoleCompletedPhase 1Universiti Sains MalaysiaNCT07262736Written as clozapine
- The Efficacy of Computerized Cognitive Remediation Therapy for Chronic SchizophreniaCompletedPhase 4Shanghai Mental Health CenterNCT03772951Written as Clozapine
- Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With SchizophreniaCompletedPhase 4University of Massachusetts, WorcesterNCT00981526Written as Clozapine
- Electroconvulsive Therapy in Clozapine Refractory SchizophreniaCompletedPhase 1/2Northwell HealthNCT00042224Written as Clozapine
- Adjunctive Low-dose Metformin in Patients With Schizophrenia and Metabolic AbnormalitiesCompletedPhase 4Taipei Medical University WanFang HospitalNCT02751307Written as clozapine 100 mg
- Glycine and D-Cycloserine in SchizophreniaWithdrawnPhase 3Massachusetts General HospitalNCT00000372Written as Clozapine
As the comparator · 2 — what is tested is compared with Clozapine
- Comparison of Maintenance ECT Versus Clozapine in Treatment-resistant SchizophreniaCompletedPhase 4All India Institute of Medical Sciences, BhubaneswarNCT03807882Written as Clozapine
- A Study Comparing the Efficacy and Tolerability of Ziprasidone vs. Clozapine for the Treatment of Schizophrenia in Patients Who Continue to Have Symptoms on or Cannot Tolerate Other Antipsychotic DrugsCompletedPhase 3Pfizer's Upjohn has merged with Mylan to form Viatris Inc.NCT00649844Written as Clozapine
Codes
What other systems call Clozapine · ClinicalTrials.gg INT007241
- MeSH (NLM) D003024ClozapineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) J60AR2IKICCLOZAPINEConfirmed FDA, NLM, Wikidata
- RxNorm 2626Confirmed FDA, Wikidata
- Wikidata Q221361clozapineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C28936ClozapineOne source FDA
- DrugBank DB00363One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D003024 | Clozapine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | J60AR2IKIC | CLOZAPINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2626 | — | Confirmed FDA, Wikidata |
| Wikidata | Q221361 | clozapine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C28936 | Clozapine | One source FDA |
| DrugBank | DB00363 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.