An observational study in Early Psychosis, Psychosis and Schizophrenia, sponsored by University of Minnesota. Recruiting at 2 sites in United States. Open to participants aged 15 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-22.
Sponsored by University of Minnesota · Observational
Among 19 studies in Psychotic Disorders by University of Minnesota — 4 open to participants now, 6 under way, 2 of them phase 3. Psychotic Disorders · University of Minnesota.
Among the 19 studies in Psychotic Disorders by University of Minnesota, this one is one of 2 that started in 2025, is one of 6 observational ones, and was the 19th registered.
1,587 studies on the registry are indexed under Psychotic Disorders; 281 are open to participants now.
Browse Psychotic Disorders studies →4 of the 19 studies in Psychotic Disorders by University of Minnesota are open now, in 1 country. Recruiting first, the newest first:
University of Minnesota · Sites in United States
University of Minnesota · Sites in United States
University of Minnesota · Sites in United States
By country, each count listing its studies:
Of the 205 Psychotic Disorders studies recruiting now, 53 (26%) set no upper age limit and 143 (70%) stop at 75 or younger; 51 take children under 18; 41 take healthy volunteers.
This study: 15 Years to 45 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
19 studies; the count open now beside each. This study's row is marked.
First in 2002; this study’s year is marked. 2 started in 2025.
This study's planned enrollment of 500 is above the median of 123 across 221 observational studies indexed under Psychotic Disorders.
Median enrollment 55 across the 13 interventional studies, 76 across the 6 observational. Of the 12 that completed or were terminated, 5 (42%) have results posted.
This tab as a report to print or save as PDF → With an account.
University of Minnesota is the lead sponsor of 1,216 studies on the registry; 197 are open to participants now.
Of its 136 completed or terminated interventional studies of FDA-regulated products, 95 (70%) have results posted.
2 of the studies in Psychotic Disorders by University of Minnesota that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05877716University of MinnesotaEPI-MINN: Targeting Cognition and Motivation - National | 2027-03-31 |
| NCT05112432University of MinnesotaEPI-MINN: Targeting Cognition and Motivation | 2027-06-30 |
Among the 19 studies in Psychotic Disorders by University of Minnesota, from their registry updates:
Nothing recorded among them since 2026-09-25.
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This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and healthy control participants.
Participants will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments. The study will evaluate performance and computed parameters from the Translational Orientation Pattern Expectancy task and Translational Bandit Task, along with EEG variables related to cognitive control, reward processing, and neural synchrony.
The study aims to better understand heterogeneity in early psychosis and identify neurocognitive and neurophysiologic markers that may inform future precision psychiatry approaches.
State Representation in Early Psychosis 2 is an observational study of individuals with early psychosis and healthy control participants. The study is part of an NIH Silvio O. Conte Center for Translational Mental Health Research grant and is designed to examine behavioral and neural markers of state representation processes in early psychosis.
The study will enroll individuals with early psychosis and demographically similar healthy controls. Participants will complete interviews, self-report measures, behavioral tasks, cognitive assessments, and electroencephalography assessments. The study focuses on computational and EEG measures related to state estimation, state maintenance, and state learning.
Participants will complete variants of two computerized tasks: the Translational Orientation Pattern Expectancy task and the Translational Bandit Task. EEG will be collected while participants complete these tasks and during resting state. EEG variables of interest include P300, reward positivity, phase synchrony, spectral power density slope, and prefrontal/parietal theta.
Clinical and functional measures will also be collected, including measures of psychiatric symptoms, functioning, motivation, pleasure, discrimination, disability, depression, anxiety, and general cognitive ability. The study will compare early psychosis participants with healthy control participants and evaluate how behavioral, computational, EEG, cognitive, clinical, and functional measures relate to heterogeneity in early psychosis.
The study population includes individuals with early psychosis and demographically similar healthy control participants. Early psychosis participants will have a clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis. Healthy control participants will be recruited from the community and must not meet DSM-5 criteria for psychotic or bipolar disorder or have a first-degree family history of psychotic or bipolar disorder. Participants will be 15 to 45 years old and will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
All participants:
Early Psychosis participants:
Exclusion Criteria:
All participants:
Early Psychosis participants:
- Presence of a major neurological disorder
Healthy Control participants:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Clinically significant
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants with a clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis. Participants will complete clinical interviews, self-report measures, cognitive/computerized tasks, and EEG assessments.
Community control participants without psychotic or bipolar disorder and without a first-degree family history of psychotic or bipolar disorder. Participants will complete clinical interviews, self-report measures, cognitive/computerized tasks, and EEG assessments.
Combined TOPX and TBT State Representation Parameter Score
Performance and computed parameters from the Translational Orientation Pattern Expectancy task and Translational Bandit Task will be combined to evaluate state estimation, state maintenance, and state learning processes. The Translational Orientation Pattern Expectancy task is a cognitive control task used to evaluate dysregulated expectancy through responses to expected and unexpected stimuli. The Translational Bandit Task is a reward learning task used to evaluate responses to rewards. Together, task-derived parameters will be combined into model-derived parameter scores reflecting state estimation, state maintenance, and state learning. Unit: model-derived parameter score
Time frame: Baseline study assessment, up to 8 weeks
P300 Amplitude During AX-CPT Task
P300 will be assessed during the AX-CPT task as a parietally maximal positive-going event-related potential component occurring approximately 300 to 600 milliseconds after stimulus presentation. Cue-locked P300 responses to A versus B cues and probe-locked P300 responses to AX versus AY probes will be used to assess attention allocation and context/state representation during proactive and reactive cognitive control. Unit: Microvolts
Time frame: Baseline study assessment, up to 8 weeks
Reward Positivity Amplitude During Translational Bandit Task
Reward positivity will be assessed during the Translational Bandit Task as a frontocentrally maximal event-related potential component occurring approximately 250 to 350 milliseconds after reward versus non-reward feedback. Reward positivity will be used to assess reward sensitivity and reinforcement learning. Unit: Microvolts
Time frame: Baseline study assessment, up to 8 weeks
Resting-State EEG Phase Synchrony
Phase synchrony will be assessed during resting-state EEG using measures of the consistency of phase relationships between electrode sites, such as phase-locking value or weighted phase-lag index. Resting-state EEG will include eyes-closed and eyes-open conditions and will be used to assess coordination of neural activity across distributed brain regions. Unit: phase-locking value
Time frame: Baseline study assessment, up to 8 weeks
Resting-State EEG Spectral Power Density Slope
The slope of spectral power density will be assessed during resting-state EEG as the aperiodic, 1/f-like component of the power spectrum. The slope will be estimated after separating periodic oscillatory activity from the aperiodic component and will be used to assess cortical excitation/inhibition balance and arousal state. Unit: aperiodic exponent
Time frame: Baseline study assessment, up to 8 weeks
Prefrontal and Parietal Theta Power
Prefrontal and parietal theta activity will be assessed using electroencephalography during computerized tasks and resting state as a neurophysiologic measure related to cognitive control and state representation. Unit: decibels
Time frame: Baseline study assessment, up to 8 weeks
Minnesota Symptoms Severity Questionnaire Score
Physical and mental well-being symptoms will be assessed using the 29-item Minnesota Symptoms Severity questionnaire. Items are scored from 1, absent, to 5, occurring nearly every day. Higher scores indicate higher frequency of physical and mental health symptoms. Unit: points
Time frame: Baseline study assessment, up to 8 weeks
Scale for the Assessment of Negative Symptoms Score
Negative symptoms will be assessed using the Scale for the Assessment of Negative Symptoms. Items are scored from 0, absent, to 5, severe. Higher scores indicate greater negative symptom severity. Unit: points
Time frame: Baseline study assessment, up to 8 weeks
Scale for the Assessment of Positive Symptoms Score
Positive symptoms will be assessed using the Scale for the Assessment of Positive Symptoms. Items are scored from 0, absent, to 5, severe. Higher scores indicate greater positive symptom severity. Unit: points
Time frame: Baseline study assessment, up to 8 weeks
Brief Psychiatric Rating Scale Score
Psychiatric symptoms will be assessed using the Brief Psychiatric Rating Scale. The scale assesses 24 psychiatric symptom constructs, with items scored from 1, absent, to 7, extremely severe. Higher scores indicate greater psychiatric symptom severity. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Schizotypal Personality Questionnaire-Brief Revised Score
Schizotypal traits will be assessed using the 32-item Schizotypal Personality Questionnaire-Brief Revised. Items are scored from 0, strongly disagree, to 4, strongly agree. Higher scores indicate greater schizotypal trait severity. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Intersectional Discrimination Index Score
Experiences of discrimination will be assessed using the 31-item Intersectional Discrimination Index. The measure uses multiple item response scales to assess experiences of, and worries about, discrimination. Higher scores indicate more frequent or more intense experiences or concerns related to discrimination. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Motivation and Pleasure Scale-Self Report Score
Motivation and pleasure will be assessed using the 15-item Motivation and Pleasure Scale-Self Report. Items are scored from 0 to 4. Lower scores indicate greater deficits in motivation and pleasure. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
World Health Organization Disability Assessment Schedule Score
Disability will be assessed using the 15-item World Health Organization Disability Assessment Schedule. Items are scored from 1, none, to 5, extreme or cannot do. Higher scores indicate greater disability. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Global Functioning Social Scale Score
Social functioning will be assessed using the Global Functioning Social scale. Scores range from 1, extreme social isolation, to 10, superior social functioning. Lower scores indicate worse social functioning. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Test My Brain Matrix Reasoning Score
Fluid cognitive ability and nonverbal reasoning will be assessed using the Matrix Reasoning assessment from Test My Brain. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Test My Brain Digit Symbol Matching Score
Processing speed and visual short-term memory will be assessed using the Digit Symbol Matching assessment from Test My Brain. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Test My Brain Verbal Paired Associates Memory Score
Verbal memory and episodic memory will be assessed using the Verbal Paired Associates Memory assessment from Test My Brain. Unit: points
Time frame: Baseline study assessment, up to 8 weeks
Test My Brain Multiracial Emotion Recognition Score
Face emotion perception and emotion identification will be assessed using the Multiracial Emotion Recognition assessment from Test My Brain. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Wechsler Test of Adult Reading Score
Verbal intelligence will be assessed using the Wechsler Test of Adult Reading. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Global Functioning Role Scale Score
Role functioning will be assessed using the Global Functioning Role scale. Scores range from 1, extremely poor role functioning, to 10, superior role functioning. Lower scores indicate worse occupational or role functioning. Unit: Points
Time frame: Baseline study assessment, up to 8 weeks
Started Oct 2025 (actual). Primary completion is estimated for Jun 2030, 56 months after the start.
Of 74 non-industry observational studies under Psychotic Disorders, half reached primary completion within 64 months of starting (the median), counting those still running; a quarter within 35 and three quarters within 124. This study's planned 56 months is below that.
Counting every sponsor, half of 76 studies reached it within 64 months; a quarter within 35 and three quarters within 124.
How these figures are worked out, and which studies are left out of them.
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