An observational study in Atopic Dermatitis, Pruritus and Chronic Pruritus of Unknown Origin, sponsored by Replior AB. Recruiting at 1 site in France. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-11-04.
Sponsored by Replior AB · Observational
Nocturnal scratching is a frequent and meaningful symptom in dermatological conditions such as atopic dermatitis. It may reflect underlying disease activity and can substantially disrupt overall sleep and quality of life. Existing approaches to characterizing Nocturnal Scratching-such as self-reports, sleep diaries, and video monitoring-are often subjective, labor-intensive, or lack scalability for widespread use.
Emerging wearable technologies offer an alternative, by enabling objective, continuous, and non- invasive signal related to scratch behavior during sleep.
The primary objective of this analytical validation study is to evaluate the characteristics of the Replior ScratchSense designed to detect and quantify Nocturnal Scratch behavior in users. This includes validating the accuracy, precision, specificity, and overall reliability of the ring's scratch detection algorithm in a controlled environment.
Sleep tracking as secondary objective. Replior ScratchSense ring (scratch and sleep research tracking)
1,591 studies on the registry are indexed under Dermatitis, Atopic; 286 are open to participants now.
This study's planned enrollment of 35 is below the median of 150 across 282 observational studies indexed under Dermatitis, Atopic.
Browse Dermatitis, Atopic studies →This is the only study on the registry with Replior AB as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Willing and able to wear two finger-worn sensors, one on each hand (on the index or middle finger), during sleep for three nights. Willing to undergo a video recording using thermal camera overnight in a controlled environment during sleep for three nights. Willing to wear the PSG system during sleep as part of the protocol during sleep for three nights.
Able and willing to follow all study instructions, including completing questionnaires and attending study visits. Written informed consent signed prior to selection, included specific thermal video recording consent.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Male / female participant, aged 18 to 65 years inclusive. Negative pregnancy test at screening for women. Presence of itch-related and/or scratching-inducing conditions: documented or self-reported history of nocturnal itching and scratching, due to conditions such as:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Childbearing potential
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Concerning Nocturnal Scratch, each participant will be equipped with two Replior ScratchSense rings, worn on the index or middle finger of each hand
Device: Scratch and sleep research tracking
Replior ScratchSense finger worn sensor in detecting and characterizing nocturnal scratching through motion and contact vibration signals and collecting signals associated with sleep related movement patterns and scratch-related intensity and pressure.
Number of Scratch bout
Scratch Bout: a group of one or more Scratch Events occurring in close temporal proximity.
Time frame: From enrollment to Night 3 (Visit3)
Total Sleep Time (TST)
Minutes of sleep across the night; the total minutes actually spent asleep during the night.
Time frame: From enrollment to Night 3
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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