An interventional study of TCM fumigation nursing intervention and Routine care in Refractory Pruritus, sponsored by Second Affiliated Hospital of Nanchang University. Active, not recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-09.
Sponsored by Second Affiliated Hospital of Nanchang University · Not applicable, Interventional, and Supportive care
Objective: To investigate the application effect of traditional Chinese medicine (TCM) fumigation nursing intervention in uremic patients with refractory skin pruritus undergoing hemoperfusion treatment.
Methods: A total of 68 uremic patients with refractory skin pruritus admitted to the Department of Nephrology of a large hospital in Jiangxi, China, between May 2026 and May 2027 were enrolled as study subjects. All patients received routine hemodialysis combined with hemoperfusion treatment as prescribed by physicians. They were divided into a control group (n = 34) and an experimental group (n = 34) using a random number table method. The control group received routine nursing care, while the experimental group received additional TCM fumigation nursing intervention on the basis of the control group. The Visual Analogue Scale (VAS) score, Pittsburgh Sleep Quality Index (PSQI) score, 36-Item Short Form Health Survey (SF-36) score, and blood biochemical indicators (serum calcium, serum phosphorus, and high-sensitivity C-reactive protein) were compared between the two groups before intervention and after 8 weeks of intervention.
490 studies on the registry are indexed under Pruritus; 93 are open to participants now.
This study's planned enrollment of 80 is above the median of 60 across 422 interventional studies indexed under Pruritus.
Browse Pruritus studies →Second Affiliated Hospital of Nanchang University is the lead sponsor of 85 studies on the registry; 52 are open to participants now.
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Aged ≥18 years, with clear consciousness, and able to cooperate in completing scale assessments and treatment procedures; ② All patients met the diagnostic criteria for uremia;
Exclusion Criteria:
Complicated with severe cardiovascular and cerebrovascular diseases, such as unstable angina, recent myocardial infarction, or the acute phase of stroke;
A definite history of allergy to drugs or contactants, especially allergy to any component of the TCM fumigation prescription;
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
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You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Routine care
Drug: TCM fumigation nursing intervention · Other: Routine care
Before fumigation, a nephrologist completed the patient's condition assessment and ruled out fumigation-related contraindications. All fumigation procedures were performed by nursing staff who had received specialized TCM nursing training. The Chinese herbal decoction pieces used for fumigation in this study were uniformly purchased from the hospital's TCM pharmacy from the same batch number. The herbs were added to approximately 3000 mL of clean water and soaked for 30 min, then brought to a boil over high heat and decocted over low heat for 30 min. The decoction was filtered, and 2000 mL of water was added to the residue for a second decoction for 20 minutes. The two filtrates were combined and concentrated to approximately 2000 mL. The decoction was placed in a TCM fumigation therapeutic apparatus, and the fumigation temperature was set at 40-45°C. The patient was seated in the fumigation cabin with the whole-body skin exposed, and the fumigation duration was set at 25-30 min.
Explain to patients the triggers and predisposing factors of uremic pruritus and the key points of skin protection; provide dedicated medication guidance on phosphate binders; and guide patients to use mild, non-irritating bathing products. After bathing, instruct patients to apply moisturizer promptly, twice daily over the whole body, with the frequency increased as appropriate for pruritic areas. Dynamically observe the location and severity of pruritus and the condition of skin breakdown, and correct improper behaviors such as scratching the skin. Provide dietary health guidance based on the patient's calcium and phosphorus metabolism, and offer timely emotional counseling when the patient is in a poor mood.
Pruritus severity was assessed using the Visual Analogue Scale (VAS)
Time frame: From enrollment to the end of treatment at 8 weeks
Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI)
Time frame: From enrollment to the end of treatment at 8 weeks
Quality of life was assessed using the 36-Item Short Form Health Survey (SF-36)
Time frame: From enrollment to the end of treatment at 8 weeks
Started May 2026 (actual). Primary completion is estimated for May 2027, 12 months after the start.
Of 85 non-industry interventional studies with no phase under Pruritus, half reached primary completion within 7 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 14. This study's planned 12 months is above that.
Counting every sponsor, half of 101 studies reached it within 7 months; a quarter within 3 and three quarters within 13.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital of Nanchang University