GlaxoSmithKline: Pruritus trials

The registry lists 12 Pruritus studies with GlaxoSmithKline as lead sponsor. 2 are open to participants now and 4 have results posted.

Phase 1 4Phase 2 3Phase 3 4No phase 1(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• J-LINX: Japan LINerixibat eXtension StudyNot yet recruitingNCT07860710Phase 3
• Linerixibat Compassionate Use for Cholestatic Pruritus Adult Patients With Primary Biliary Cholangitis (PBC)AvailableNCT05448170
• Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)CompletedNCT04950127Phase 3Results posted
• Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary CholangitisCompletedNCT02966834Phase 2Results posted
• Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate CreamCompletedNCT02075632Phase 2Results posted
• Safety Study of Levocetirizine Oral Solution for Japanese PediatricsCompletedNCT01563081Phase 3Results posted
• Food Effect Study of Linerixibat Tablets in Healthy Adult ParticipantsCompletedNCT05435170Phase 1
• Phase I Study of Linerixibat in Adults With Moderate Hepatic Impairment and Healthy ControlsCompletedNCT05393076Phase 1
• Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Adult ParticipantsCompletedNCT05133830Phase 1
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of PruritusCompletedNCT01899703Phase 2
• Investigation of Topical SB705498 on Healthy VolunteersCompletedNCT01673529Phase 1
• Study Of Cutaneous Disease Accompanied With Pruritus In PediatricsCompletedNCT00257582Phase 3