Drug
Difelikefalin clinical trials
Also written CR845 and MR13A9.
- studies test it
- 28
- open now
- 2
- in phase 3
- 12
- first study started
- 2009
Keep track of what changes. Save the difelikefalin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Studies by the year they started
28 studies that test it; most in 2019 (7)
| Year | Studies |
|---|---|
| 2009 | 1 |
| 2011 | 1 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 1 |
| 2018 | 3 |
| 2019 | 7 |
| 2021 | 2 |
| 2022 | 3 |
| 2023 | 3 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 4
- Phase 2
- 14
- Phase 3
- 12
- No phase
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 27 · Other 1
Cara Therapeutics, Inc. (22) · Vifor Fresenius Medical Care Renal Pharma (3) · Kissei Pharmaceutical Co., Ltd. (2) · Chittagong Medical College (1)
Studies
Open first, then newest update. How each study uses difelikefalin is read from its arms, and is right about nine times in ten.
Testing it · 28
- Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe PruritusRecruitingPhase 2Vifor Fresenius Medical Care Renal PharmaNCT06593392Written as Difelikefalin
- Difelikefalin for Itching in Hemodialysis Patients With Chronic Kidney DiseaseNot yet recruitingNot applicableChittagong Medical CollegeNCT07526324Written as Difelikefalin Injection
- A Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus.CompletedPhase 2Kissei Pharmaceutical Co., Ltd.NCT03802617Written as MR13A9
- Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe PruritusCompletedPhase 3Vifor Fresenius Medical Care Renal PharmaNCT05885737Written as Difelikefalin Injection
- A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus.CompletedPhase 3Kissei Pharmaceutical Co., Ltd.NCT04711603Written as MR13A9
- Pharmacokinetics of Intravenous Difelikefalin in Chinese Adult Subjects on HaemodialysisCompletedPhase 1Vifor Fresenius Medical Care Renal PharmaNCT05885763Written as Difelikefalin Injection
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia ParestheticaTerminatedPhase 2/3Cara Therapeutics, Inc.NCT05978063Written as difelikefalin 2.0 mg tablets
- CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe PruritusTerminatedPhase 3Cara Therapeutics, Inc.NCT05356403Written as Difelikefalin 1 mg Oral Tablet
- A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe PruritusTerminatedPhase 3Cara Therapeutics, Inc.NCT05342623Written as Difelikefalin 1 mg Oral Tablet
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid for Moderate to Severe Pruritus in Subjects With Atopic DermatitisTerminatedPhase 3Cara Therapeutics, Inc.NCT05387707Written as difelikefalin 0.25 mg
- A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe PruritusCompletedPhase 2Cara Therapeutics, Inc.NCT03617536Written as CR845 0.25 mg Oral Tablet
- Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe PruritusTerminatedPhase 2Cara Therapeutics, Inc.NCT03995212Written as CR845 1.0 mg
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)CompletedPhase 2Cara Therapeutics, Inc.NCT04706975Written as difelikefalin 2.0 mg
- CR845-100303: Study to Assess the Potential of Physical Withdrawal From Intravenous CR845 (Difelikefalin) in Hemodialysis PatientsCompletedPhase 1Cara Therapeutics, Inc.NCT05533008Written as CR845 0.5 mcg/kg
- CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusCompletedPhase 3Cara Therapeutics, Inc.NCT03636269Written as CR845 0.5 mcg/kg
- A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)CompletedPhase 3Cara Therapeutics, Inc.NCT03422653Written as CR845 0.5 mcg/kg
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic DermatitisCompletedPhase 2Cara Therapeutics, Inc.NCT04018027Written as difelikefalin 0.25 mg
- CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusCompletedPhase 3Cara Therapeutics, Inc.NCT03998163Written as CR845 0.5 mcg/kg
- Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusCompletedPhase 3Cara Therapeutics, Inc.NCT03281538Written as CR845
- A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or KneeCompletedPhase 2Cara Therapeutics, Inc.NCT02944448Written as CR845 tablet 1 mg
See all 28 studies that test difelikefalin →
As the comparator · 1 — what is tested is compared with difelikefalin
Codes
What other systems call difelikefalin · ClinicalTrials.gg INT001262
- MeSH (NLM) C000657129difelikefalinConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) NA1U919MRODIFELIKEFALINConfirmed FDA, NLM, Wikidata
- RxNorm 2569089One source FDA
- Wikidata Q21098992difelikefalinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C174752DifelikefalinOne source FDA
- DrugBank DB11938One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000657129 | difelikefalin | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | NA1U919MRO | DIFELIKEFALIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2569089 | — | One source FDA |
| Wikidata | Q21098992 | difelikefalin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C174752 | Difelikefalin | One source FDA |
| DrugBank | DB11938 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.