An interventional study of Kaia Relief - Cycle System (Day and Night) in Premenstrual Syndrome, Menstrual Discomfort and Premenstrual Symptoms, sponsored by Vivance Group. Recruiting at 1 site in United States. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Vivance Group · Not applicable, Interventional, and Treatment
This is a single-group, open-label, decentralized clinical trial evaluating the effects of the Kaia Relief - Cycle System (a commercial dietary supplement consisting of Day and Night capsules) on premenstrual symptom severity, menstrual discomfort, and overall well-being in premenopausal women. Forty-five healthy premenopausal women aged 18-45 with regular menstrual cycles and self-reported recurrent premenstrual symptoms will be enrolled.
The study spans approximately 12 weeks across three consecutive menstrual cycles. Cycle 1 serves as a no-product baseline cycle during which participants complete validated questionnaires on Day 5. During Cycles 2 and 3, participants take two Day capsules each morning and two Night capsules each evening, beginning 7 days before their anticipated period and continuing through Day 2 of their cycle. Questionnaires are completed on Day 5 of each product cycle. All study activities are conducted remotely via the Citruslabs digital study platform; there are no in-person visits, blood draws, or laboratory procedures.
182 studies on the registry are indexed under Premenstrual Syndrome; 30 are open to participants now.
This study's planned enrollment of 45 is below the median of 70 across 157 interventional studies indexed under Premenstrual Syndrome.
Browse Premenstrual Syndrome studies →This is the only study on the registry with Vivance Group as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Dietary Supplement: Kaia Relief - Cycle System (Day and Night)
All enrolled participants receive the Kaia Relief - Cycle System (two Day capsules each morning and two Night capsules each evening with food) beginning 7 days before their anticipated period and continuing through Day 2 of their cycle, during Cycles 2 and 3.
Change in Premenstrual and Menstrual Discomfort Symptoms as Assessed by the Menstrual Symptom Questionnaire (MSQ)
Mean change in MSQ total score, calculated according to the Chesney \& Tasto method including applicable reverse-scoring, from Baseline (Day 5 of Cycle 1) to the end of Cycle 3 (Day 5 of Cycle 3)
Time frame: Baseline (Day 5 of Cycle 1) to Day 5 of Cycle 3 (each cycle is 28 days)
Change in Menstrual Pain Intensity as Assessed by the Numeric Pain Rating Scale (NPRS)
Mean change in NPRS score from Baseline (Day 5 of Cycle 1) to the end of Cycle 3 (Day 5 of Cycle 3)
Time frame: Baseline (Day 5 of Cycle 1) to Day 5 of Cycle 3 (each cycle is 28 days)
Participant-Perceived Effects on Premenstrual Symptoms
Participants' experience of their premenstrual symptoms and satisfaction with the product, assessed via questionnaires
Time frame: Baseline (Day 5 of Cycle 1) to Day 5 of Cycle 3 (each cycle is 28 days)
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.