Premature Ejaculation clinical trials
The registry lists 106 studies for Premature Ejaculation across more than 10 countries. 17 are recruiting or about to start. 83 of them are mainly about Premature Ejaculation (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
GlaxoSmithKline (6) · Sohag University (5) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5) · Janssen Research & Development, LLC (4) · Plethora Solutions Ltd (4) · Boston Medical Group (4) · Virility Medical Ltd. (3) · Alza Corporation, DE, USA (3)
What is being tested here
Drugs under test in Premature Ejaculation studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Paroxetine | 1 | 2 | 4 |
| Botulinum toxin type A | 1 | 0 | 3 |
| KH001 | 1 | 0 | 2 |
| Hyaluronic Acid | 1 | 1 | 2 |
| VV913 | 1 | 0 | 1 |
| Dapoxetine | 0 | 10 | 12 |
| IX-01 | 0 | 0 | 2 |
| Lidocaine | 0 | 0 | 2 |
| Epelsiban | 0 | 0 | 2 |
| Clomipramine | 0 | 1 | 2 |
Drug classes tested here SSRIs 2 open · Local anesthetics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Impact of Depression Severity on Sexual Dysfunction · Sohag University
- Dec 2026Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study · Benha University
- Mar 2027Pelvic Floor Therapies for Lifelong Premature Ejaculation · Tanta University
- May 2027Male Pelvic Floor Muscle Rehabilitation Exercises · Dream Video LLC
Who these studies take
Of the 9 Premature Ejaculation studies recruiting now, 2 (22%) set no upper age limit and 6 (67%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 8 (89%) for men only; 3 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 1 (11%) | 8 (89%) |
| 30 | 1 (11%) | 9 (100%) |
| 40 | 1 (11%) | 9 (100%) |
| 50 | 1 (11%) | 7 (78%) |
| 65 | 1 (11%) | 4 (44%) |
| 75 | 1 (11%) | 3 (33%) |
| 85 | 1 (11%) | 3 (33%) |
Across all 106 studies, recruiting or not: 68% stop at 75 or younger and 65% at 65; 4% take children; 2% are for women only and 93% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Premature Ejaculation studies take
Of 25 interventional studies with no phase under Premature Ejaculation, half reached primary completion within 9 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 9 mo4–39 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Dorsal Penile Nerve Cryoneurolysis for Lifelong PEOct 16, 2026NCT07879105
Studies
Recruiting first, then most recently updated. Showing 50 of 106. Browse all 106 → or search them.
- Male Pelvic Floor Muscle Rehabilitation ExercisesNot yet recruitingNCT07451808Not applicable
- Ejaculatory and Orgasmic Dysfunction RegistryRecruitingNCT066054691 country
- Study to Evaluate the Potential Effects of KH-001 on Intravaginal Ejaculatory Latency Time (IELT), Patient-Reported Outcomes, and Safety in Men With Lifelong Premature Ejaculation (LPE)RecruitingNCT07434271Phase 21 country
- Evaluate the Efficacy and Safety of VV913 Capsules in the Treatment of PENot yet recruitingNCT07722780Phase 21 country
- Pelvic Floor Therapies for Lifelong Premature EjaculationRecruitingNCT07627438Not applicable1 country
- Effect of Prostatic Urethra and Seminal Vesicle Morphometry on EjaculationNot yet recruitingNCT076148541 country
- The Effectiveness of Exercise in the Treatment of Erectile Dysfunction and Premature EjaculationRecruitingNCT07442396Not applicable1 country
- Effectiveness of Pelvic Floor Therapy for the Management of Erectile Dysfunction and Premature Ejaculation.RecruitingNCT06425211Not applicable1 country
- Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized StudyNot yet recruitingNCT07236632Not applicable
- Comparison of the Efficacy and Safety of Dapoxetine, Kegel Exercises, and Acupuncture in the Treatment of Premature Ejaculation: A Randomized, Double-Blind, Placebo-Controlled TrialNot yet recruitingNCT07067970Not applicable1 country
- Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus MonotherapyNot yet recruitingNCT07057011Not applicable1 country
- Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical TrialRecruitingNCT06570135Not applicable1 country
- Development and Validation of an Anxiety Disorder Prediction Model for Premature Ejaculation PatientsRecruitingNCT066778141 country
- Clinical Study to Reduce Premature Ejaculation in Healthy Adult MenNot yet recruitingNCT06571318Not applicable
- Effectiveness and Safety of TENS Therapy for Premature EjaculationRecruitingNCT06425224Phase 31 country
- The Study on the Effectiveness and Safety of Electroacupuncture at ST36 in Treating Primary Premature EjaculationRecruitingNCT06172855Not applicable1 country
- Efficacy and Safety of Toronto Association in the Treatment of Erectile Dysfunction and Premature EjaculationNot yet recruitingNCT05052879Phase 3
- Silicone Band Versus Prilocaine Spray for Lifelong Premature EjaculationCompletedNCT07820865Not applicable1 country
- Dorsal Penile Nerve Cryoneurolysis for Lifelong PECompletedNCT07879105Not applicable1 country
- A Phase I Study to Investigate KH-001 in Healthy MalesCompletedNCT07868237Phase 11 country
- Extracorporeal Magnetic Innervation Plus Pelvic Floor Muscle Training for Premature EjaculationCompletedNCT07385222Not applicable1 country
- Impact of Depression Severity on Sexual DysfunctionActive, not recruitingNCT076274771 country
- Vagus Nerve Stimulation in Premature EjaculationCompletedNCT07300774Not applicable1 country
- Transcutaneous Posterior Tibial Nerve Stimulation for Premature EjaculationCompletedNCT04207723Not applicable1 country
- Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature EjaculationCompletedNCT07426640Not applicable1 country
- Comparative Evaluation of Safety and Efficacy of Dapoxetine, Silodosin, and Citalopram in the Management of Premature EjaculationCompletedNCT07113145Phase 41 country
- On-demand Silodosin 4mg vs Dapoxetine 60mg in Treatment of Primary Premature EjaculationCompletedNCT07081659Phase 2/31 country
- THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMESCompletedNCT070364971 country
- Primary Premature Ejaculation GeneticsCompletedNCT02109302Not applicable1 country
- Safety and Efficacy of Botulinum Toxin-A Injection Into Ischiocavernosus Muscle for Premature EjaculationActive, not recruitingNCT06851598Phase 2/31 country
- A Comparative Study of Selective Dorsal Neurectomy, Pulsed Radiofrequency Neuromodulation, and Intragranular Hyaluronic Acid Injection for Premature EjaculationCompletedNCT06777199Not applicable1 country
- The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation TherapyCompletedNCT01063881Phase 33 countries
- Transcutaneous Electrical Nerve Stimulation for the Treatment of Premature EjaculationCompletedNCT06570512Not applicable1 country
- TPTNS for Treating Patients With Premature EjaculationCompletedNCT03204890Not applicable1 country
- The Effect of Behavioral Therapy Given to Men and Their Partners'CompletedNCT05964608Not applicable1 country
- The Prevalence of Erectile Dysfunction (ED) and Premature Ejaculation (PE) in PolandCompletedNCT054621711 country
- Brain Networks Implicated in Lifelong Premature Ejaculation PatientsCompletedNCT04850703Phase 1/21 country
- Precise Use of Lidocaine Cream to Treat Primary Premature EjaculationStatus unknownNCT05749614Not applicable1 country
- Effect of Respiratory Exercises On The Intravaginal Ejaculation Latency TimeCompletedNCT05517694Not applicable1 country
- Sildenafil Added Effect in Dapoxetine Non-responding Mono-symptomatic Premature Ejaculation (PE)Status unknownNCT05556083Phase 2
- PSD502 in Subjects With Premature EjaculationCompletedNCT03578783Phase 21 country
- The Safety of Dapoxetine/Tadalafil Combination TherapyStatus unknownNCT03177746Phase 41 country
- Combined On-demand Sildenafil Citrate and Tramadol Hydrochloride for Treatment of Premature EjaculationStatus unknownNCT05183334Phase 4
- Erectile Dysfunction, Psychological Disorders, and Sexual Performance Among Men Seeking Medical Help for FertilityStatus unknownNCT049416901 country
- Chronotype and Premature EjaculationCompletedNCT048413951 country
- Assessment of Serum Levels of Vitamin D, Vitamin B12 and Folic Acid Among Patients With Lifelong Premature Ejaculation and Non-responding to Dapoxetine Treatment.CompletedNCT04355949Not applicable1 country
- Effectiveness and Tolerability of the On-demand Use of Combined Dapoxetine With Tadalafil and Combined Dapoxetine With Lidocaine 5% Spray in Treatment of Patients With Lifelong Premature Ejaculation and Non-responding to Dapoxetine Alone.Status unknownNCT04703127Phase 31 country
- Consultations Reason for Genital, Urinary or Psychological Humans in General PracticeTerminatedNCT02378779Not applicable1 country
- Evaluation of the Safety and Effectiveness of the vPatch DeviceCompletedNCT03942367Not applicable2 countries
- IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE)CompletedNCT02232425Phase 22 countries