An interventional study of Transcutaneous Auricular Vagus Nerve Stimulation in Premature Ejaculation, sponsored by Bahçeşehir University. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-04.
Sponsored by Bahçeşehir University · Not applicable, Interventional, and Treatment
Among 14 studies in Premature Ejaculation with a site in Turkey — 3 open to participants now, 3 under way, none of them phase 3. Premature Ejaculation · Turkey.
Among the 14 studies in Premature Ejaculation with a site in Turkey, this one is the 3rd largest by enrollment of the 10 interventional ones, is one of 3 that started in 2025, is one of 8 with no phase, and was the 9th registered.
106 studies on the registry are indexed under Premature Ejaculation; 17 are open to participants now.
This study's enrollment of 102 is above the median of 84 across 89 interventional studies indexed under Premature Ejaculation.
Browse Premature Ejaculation studies →3 of the 14 studies in Premature Ejaculation with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 9 Premature Ejaculation studies recruiting now, 2 (22%) set no upper age limit and 6 (67%) stop at 75 or younger; 0 take children under 18; 3 take healthy volunteers.
This study: 30 Years to 50 Years · male · healthy volunteers too.
The full table on the hub →14 studies; the count open now beside each. This study's row is marked.
First in 2016; this study’s year is marked. 3 started in 2025.
Median enrollment 67 across the 10 interventional studies, 102 across the 4 observational. Of the 10 that completed or were terminated, 0 (0%) have results posted.
2 of 14 have an industry lead sponsor. The 10 most frequent:
Bahçeşehir University is the lead sponsor of 128 studies on the registry; 26 are open to participants now.
Bahçeşehir University has 2 studies filed under Premature Ejaculation — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 14 studies in Premature Ejaculation with a site in Turkey, from their registry updates:
Introduction: Premature ejaculation (PE), one of the most common sexual dysfunctions in men, negatively affects sexual function and quality of life. Transcutaneous auricular vagal nerve stimulation (taVNS) provides autonomic regulation non-invasively by balancing the sympathetic and parasympathetic systems.
Objective: To investigate the effectiveness of taVNS on autonomic and sexual function in men with PE and to compare the effectiveness of different taVNS application methods.
Materials and Methods: This prospective, randomized, sham-controlled, single-blind (evaluator) study will be conducted on 102 men with PE. Physical, sociodemographic, and clinical characteristics will be evaluated. Heart rate variability will be assessed using the Polar H10 device, premature ejaculation status using the Premature Ejaculation Assessment Questionnaire, and sexual function using the International Index of Erectile Function. Participants will be randomized into two groups (intra-auricular taVNS and sham-taVNS). taVNS treatment will be administered to each group three days per week, with 20-minute sessions, for 12 weeks. For in-ear taVNS, bilateral ear sets with a 36-square-millimeter surface area will be used to stimulate the tragus and concha will be used to stimulate the tragus and concha for intra-auricular taVNS, while adhesive electrode pads with a similar surface area of 36 square millimeters (3 mm × 12 mm) will be used for retroauricular taVNS. The taVNS protocol includes bilateral auricular stimulation for 20 minutes, a stimulation frequency of 25 hertz (Hz), a pulse width of 250 μs, suprathreshold current (0.13-50 mA), and a biphasic mode. Sham group will also have the same specially designed electrodes placed inside the ear. The device will be turned on but set to 0 mA amplitude, so no electrical stimulation will be delivered.
Premature ejaculation (PE) is one of the most common sexual dysfunctions in men, profoundly affecting the quality of life of both the patient and their partner. Many of the proposed definitions for PE are not based on scientific data and lack diagnostic criteria. The International Society for Sexual Medicine (ISSM) defines PE (lifelong and acquired) as characterized by the following criteria: Ejaculation that occurs almost always or always before or within 1 minute of vaginal penetration (lifelong PE) or a clinically significant decrease in ejaculation latency time, typically to 3 minutes or less (acquired PE); Inability to delay ejaculation in almost all or all vaginal penetrations (lifelong and acquired PE); Negative personal consequences such as distress, anxiety, disappointment, and/or avoidance of sexual intimacy (lifelong and acquired PE). Epidemiological studies based on patient-reported outcome measures have found the prevalence of PE complaints in the male population to be as high as 20-30%. A review of the literature reveals that approaches such as behavioral therapy, exercise programs, neuromuscular electrical stimulation, and yoga are used in the treatment of premature ejaculation, in addition to pharmacological treatment. However, no study has been found that examines the effectiveness of transcutaneous auricular vagal nerve stimulation on autonomic function and PE in men with PE. Therefore, this study was designed to examine the effects of taVNS on autonomic function and PE in men with PE. Participants will be randomly assigned to two groups (intra-auricular taVNS and intra-auricular sham-taVNS). The taVNS will be administered to each group three days per week, with 20-minute session durations, for 12 weeks. The taVNS protocol includes bilateral auricular stimulation for 20 minutes, a stimulation frequency of 25 hertz (Hz), a pulse width of 250 μs, suprathreshold current (0.13-50 mA), and a biphasic mode. For intra-auricular taVNS, bilateral ear sets with a 36-square-millimeter surface area to stimulate the tragus and concha will be used for intra-auricular taVNS. Sham group will also have the same specially designed electrodes placed intra-auricularly. The device will be turned on but set to 0 mA amplitude, so no electrical stimulation will occur. Heart rate variability, Premature Ejaculation Assessment Questionnaire, International Index of Erectile Function will be assessed before and after treatment.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Transcutaneous auricular vagus nerve stimulation
Device: Transcutaneous Auricular Vagus Nerve Stimulation
Sham Stimulation
Device: Transcutaneous Auricular Vagus Nerve Stimulation
Non-invasive electrical stimulation of the vagus nerve via the tragus and conchae
Heart Rate Variability
Heart rate variability will be measured for 5 minutes over the chest using the Polar H10 device.
Time frame: Baseline and at the end of the 12th week
Plan to share: Undecided — A decision on this matter will be made later.
Ran from Dec 2025 to primary completion in Apr 2026, 4 months.
Of 25 interventional studies with no phase under Premature Ejaculation, half reached primary completion within 9 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 39. This study's 4 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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