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RecruitingNCT00921986Updated Sep 14, 2026

Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

An observational study in Arrhythmias, Cardiac, sponsored by The Cleveland Clinic. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by The Cleveland Clinic · Observational

From the registry’s dates

  • Started Mar 2009; still recruiting 17 years 8 months later.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
2,000
Ages
18 Years and older
Sex
All
01

Study summary

Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.

Read the detailed description

The long-term objective of this research is to find genes and biologic pathways causing arrhythmia syndromes and other diseases or conditions. In order to achieve this objective the investigators will collect comprehensive phenotypic data and corresponding blood and/or tissue samples into a biorepository registry of patients, presenting for cardiac arrhythmia evaluation and/or treatment, and control subjects without arrhythmias. This biorepository will be composed of two parts: 1) An Arrhythmia Biorepository of blood and tissue from patients undergoing arrhythmia procedures, cardiac surgery, or inpatient or outpatient evaluations for arrhythmias, and 2) A Collaborative Sample Biorepository for de-identified samples and data from outside institutions and clinical trials.

02

Conditions studied

  • Arrhythmias, Cardiac

Keywords

  • genetics
  • biorepository
  • cardiac death
  • atrial fibrillation
  • ventricular fibrillation
  • ventricular tachycardia
  • supraventricular tachycardias
  • premature ventricular complexes
  • premature atrial complexes
  • atrioventricular and intraventricular blocks
  • sinus node dysfunction
  • syncope
  • vasovagal reactivity
  • postural orthostatic tachycardia syndrome
03

In context

Arrhythmias, Cardiac

1,051 studies on the registry are indexed under Arrhythmias, Cardiac; 236 are open to participants now.

This study's planned enrollment of 2,000 is above the median of 200 across 467 observational studies indexed under Arrhythmias, Cardiac.

Browse Arrhythmias, Cardiac studies →

Lead sponsor

The Cleveland Clinic is the lead sponsor of 831 studies on the registry; 119 are open to participants now.

Of its 90 completed or terminated interventional studies of FDA-regulated products, 73 (81%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients undergoing arrhythmia procedures, cardiac surgery or inpatient or outpatient evaluations for arrhythmias at the Cleveland Clinic or from outside collaborative institutions or from other clinical trials.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male or female at least 18 years old
  • Subjects with a history of or current cardiac arrhythmia, family members of subjects with cardiac arrhythmias, or no cardiac arrhythmia if a Control Subject.

Exclusion criteria

Exclusion Criteria:

  • Subjects previously enrolled in the Arrhythmia BioBank
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
2,000 participants (estimated)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Arrhythmias

    Patients with arrhythmias

  • Control Subjects

    Subjects that do not have a history of cardiac arrhythmias.

06

What researchers measure

Primary outcomes

  1. Genetic variants associated with arrhythmias

    Genome-wide association study of arrhythmias

    Time frame: Baseline

07

Study locations

1 of 1 sites recruiting
  • Cleveland Clinic Foundation
    Cleveland, Ohio 44195, United States
    Recruiting
    • Mina K. Chung, MD · Principal investigator
    • David R. Van Wagoner, Ph.D. · Sub investigator
    • Jonathan D. Smith, Ph.D. · Sub investigator
    • John Barnard, Ph.D. · Sub investigator
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00921986
Responsible party
Mina Chung, MD (Principal Investigator, The Cleveland Clinic) — Principal investigator
First posted
Jun 17, 2009
Start date
Mar 2009
Primary completion
Dec 2035 (estimated)
Completion
Dec 2035 (estimated)
Last update
Sep 14, 2026

Study contacts

Mina K. Chung, MD
Contact
chungm@ccf.org
216.444.2290
Mina K. Chung, MD
principal investigator · The Cleveland Clinic

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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