An observational study in Postural Orthostatic Tachycardia Syndrome, sponsored by University of Texas Southwestern Medical Center. Recruiting at 1 site in United States. Open to participants aged 14 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-17.
Sponsored by University of Texas Southwestern Medical Center · Observational
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
This comprehensive multimodality deep phenotyping will improve the diagnostic approach, inform the development of new treatments, and allow the targeting of therapies to specific POTS patients. The investigators will further identify the diagnostic tools, biomarkers, and clinical outcome measures most relevant to defining the disorder in clinical practice.
The specific aim is to (1) Define clinical POTS classifications from multimodal clinical and laboratory data, (2) address exercise tolerance in POTS using metabolomic assessments, (3) evaluate novel POTS-specific patient outcome measures and (4) evaluate one year outcome data for POTS
Specific research tests will include blood work (for immunophenotyping and neurohormonal assessments), autonomic function testing, skin biopsy (to evaluate intraepidermal nerve fiber density), CO (Carbon Monoxide) rebreathing (for quantitative measurement of plasma volume and red blood cell mass), patient surveys (to characterize symptom profile and disease impact). Blood biosamples will be stored as a repository for future research questions.
131 studies on the registry are indexed under Postural Orthostatic Tachycardia Syndrome; 44 are open to participants now.
This study's planned enrollment of 350 is above the median of 100 across 31 observational studies indexed under Postural Orthostatic Tachycardia Syndrome.
Browse Postural Orthostatic Tachycardia Syndrome studies →University of Texas Southwestern Medical Center is the lead sponsor of 990 studies on the registry; 201 are open to participants now.
Of its 135 completed or terminated interventional studies of FDA-regulated products, 100 (74%) have results posted.
Counted across the registry records on this site, refreshed daily.
POTS patients and Normal Control
POTS Patients
Non-POTS Control Patients
Exclusion Criteria:
None of the following exclusion criteria:
Patients meeting clinical criteria for postural orthostatic tachycardia syndrome who meet other criteria for inclusion.
Diagnostic Test: multimodal diagnostic testing
Age and sex matched controls
Diagnostic Test: multimodal diagnostic testing
Serological testing, cardiac MRI, skin biopsy, cardiovascular testing, blood volume measurements
Phenotyping POTS
Assignment of participant to a phenotypic group(s) based on analysis of multimodal data
Time frame: 2 weeks
Natural history
Patient reported functional and subjective change. Surveys including COMPASS31 (Composite Autonomic Symptom Score-31) on a score of 0-100. Higher scores indicate more severe autonomic symptoms
Time frame: 1 year
Plan to share: Undecided
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Postural Orthostatic Tachycardia Syndrome→
University of Texas Southwestern Medical Center