An observational study in Polyneuropathies, Electromyography and Diagnostic Techniques, sponsored by Centre Hospitalier Universitaire de Nice. Not yet recruiting at 1 site in France. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-07-24.
Sponsored by Centre Hospitalier Universitaire de Nice · Observational
This retrospective single-center observational study will evaluate the impact of age on the diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR) in patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies. Clinical and electrophysiological data collected during routine care between January 2013 and July 2026 will be analyzed. Diagnostic performance will be assessed using receiver operating characteristic (ROC) curve analysis across predefined age groups to determine whether age-adjusted SRAR thresholds improve the differentiation between the two polyneuropathy phenotypes.
Peripheral sensory polyneuropathies are commonly classified as length-dependent (LDN) or non-length-dependent (NLDN) based on their clinical and electrophysiological features. This distinction is clinically important because it guides etiological investigations and therapeutic management. The sural-to-radial sensory nerve amplitude ratio (SRAR) is an electrophysiological marker that has been proposed to improve the diagnosis of sensory polyneuropathies and to help differentiate LDN from NLDN. Although the SRAR has traditionally been considered independent of demographic characteristics, recent evidence suggests that it decreases with aging, raising concerns about the use of a single diagnostic threshold across all age groups. The impact of age on the diagnostic performance of the SRAR, particularly in patients with non-length-dependent polyneuropathies, remains poorly characterized. This retrospective single-center study will analyze clinical and electrophysiological data from patients evaluated at the Peripheral Neuromuscular Rare Disease Reference Center of Nice University Hospital between January 2013 and July 2026. The study aims to determine whether age-adjusted SRAR thresholds improve the diagnostic discrimination between length-dependent and non-length-dependent peripheral polyneuropathies.
133 studies on the registry are indexed under Polyneuropathies; 33 are open to participants now.
This study's planned enrollment of 180 is above the median of 100 across 53 observational studies indexed under Polyneuropathies.
Browse Polyneuropathies studies →Centre Hospitalier Universitaire de Nice is the lead sponsor of 723 studies on the registry; 176 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients with peripheral sensory polyneuropathies evaluated at the Peripheral Neuromuscular Rare Disease Reference Center of Nice University Hospital between January 2013 and July 2026. Patients will be classified into length-dependent or non-length-dependent phenotypes and stratified into predefined age groups for analysis.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Other: Retrospective Medical Record Review
This observational study involves retrospective collection and analysis of routinely acquired clinical and electrophysiological data from approximately 180 patients with sensory polyneuropathy. Data extracted from medical records include demographic characteristics, clinical diagnosis, and nerve conduction study parameters, including sural and radial sensory nerve action potential amplitudes used to calculate the sural/radial amplitude ratio (SRAR). No additional diagnostic procedures, treatments, or study-specific assessments are performed. All data are obtained from standard clinical care.
Diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR)
To evaluate the diagnostic performance of the SRAR for differentiating length-dependent (LDN) from non-length-dependent (NLDN) peripheral sensory polyneuropathies according to age group, using receiver operating characteristic (ROC) curve analysis.
Time frame: Baseline (retrospective analysis of data collected between January 2013 and July 2026
Age-specific optimal SRAR diagnostic thresholds
To determine the optimal SRAR cutoff values for each predefined age group using the Youden index derived from ROC curve analysis.
Time frame: Baseline (retrospective analysis)
Comparison of SRAR values between LDN and NLDN
To compare SRAR values between patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies and to assess the influence of age on these values.
Time frame: Baseline (retrospective analysis)
Start is estimated for Sep 2026; primary completion for Sep 2026, 0 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centre Hospitalier Universitaire de Nice →