Spastic Paraplegia, Hereditary clinical trials
The registry lists 51 studies for Spastic Paraplegia, Hereditary across more than 10 countries. 20 are recruiting or about to start. 36 of them are mainly about Spastic Paraplegia, Hereditary (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Status
Who runs them
IRCCS Eugenio Medea (4) · University Hospital Tuebingen (3) · Shanghai 6th People's Hospital (3) · Boston Children's Hospital (3) · IRCCS Fondazione Stella Maris (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Assistance Publique - Hôpitaux de Paris (3) · Radboud University Medical Center (2)
What is being tested here
Drugs under test in Spastic Paraplegia, Hereditary studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Leucovorin | 1 | 0 | 1 |
| Cycloserine | 0 | 0 | 1 |
| Chenodeoxycholic Acid | 0 | 0 | 1 |
| Resveratrol | 0 | 0 | 1 |
| Atorvastatin | 0 | 0 | 1 |
| 4-Aminopyridine | 0 | 0 | 1 |
| Miglustat | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Dec 202612-Week Strength and Functional Exercise Program for Hereditary Spastic Paraplegia Trial (HSPMOVE) · Hospital de Clinicas de Porto Alegre
- Dec 2026The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children · University of Alberta
- Dec 2026Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP) · IRCCS Eugenio Medea
- Dec 2026Natural History Study of Patients with HPDL Mutations · University of California, San Diego
- Jan 2027Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia · IRCCS Eugenio Medea
- Mar 2027Enhancement of Quality of Work And Life · Radboud University Medical Center
- Mar 2027A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP · Shanghai 6th People's Hospital
- Apr 2027Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) · Boston Children's Hospital
- Jun 2027Non-invasive Spinal Stimulation for Gait in Genetic Spasticity · University of Washington
Who these studies take
Of the 17 Spastic Paraplegia, Hereditary studies recruiting now, 10 (59%) set no upper age limit and 7 (41%) stop at 75 or younger. 13 (76%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 12 (71%) | 12 (71%) |
| 18 | 16 (94%) | 16 (94%) |
| 30 | 16 (94%) | 16 (94%) |
| 40 | 14 (82%) | 14 (82%) |
| 50 | 13 (76%) | 13 (76%) |
| 65 | 13 (76%) | 13 (76%) |
| 75 | 10 (59%) | 10 (59%) |
| 85 | 10 (59%) | 10 (59%) |
Across all 51 studies, recruiting or not: 33% stop at 75 or younger and 18% at 65; 57% take children; 2% are for women only and 4% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
- Rare Disease Registry Database for Movement Disorders in Southern Anhui ProvinceOct 23, 2026NCT07838883
Newly registered1
- Non-invasive Spinal Stimulation for Gait in Genetic SpasticityNov 12, 2026NCT07930481
Studies
Recruiting first, then most recently updated. Showing 50 of 51. Browse all 51 → or search them.
- Non-invasive Spinal Stimulation for Gait in Genetic SpasticityEnrolling by invitationNCT07930481Not applicable1 country
- Rare Disease Registry Database for Movement Disorders in Southern Anhui ProvinceRecruitingNCT078388831 country
- TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic AtaxiasRecruitingNCT077986749 countries
- 12-Week Strength and Functional Exercise Program for Hereditary Spastic Paraplegia Trial (HSPMOVE)Enrolling by invitationNCT07561359Not applicable1 country
- Neuromodulation to Enhance Motor Function in HSPRecruitingNCT07417943Not applicable1 country
- STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic StrategiesRecruitingNCT065720461 country
- Spastic Paraplegia - Centers of Excellence Research NetworkRecruitingNCT065539761 country
- Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)RecruitingNCT053546221 country
- Registry and Natural History Study for Early Onset Hereditary Spastic ParaplegiaRecruitingNCT047128121 country
- The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in ChildrenRecruitingNCT07090057Not applicable1 country
- Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic PathologyRecruitingNCT07136844Not applicable1 country
- Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)RecruitingNCT067287871 country
- Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)Not yet recruitingNCT06948019Phase 1/21 country
- A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSPRecruitingNCT069361631 country
- Natural History Study of Patients with HPDL MutationsRecruitingNCT058482711 country
- A Prospective Cohort Study of ITB Treatment for HSPRecruitingNCT068447341 country
- Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/SpastRecruitingNCT06229626Not applicable1 country
- Calcium Folinate Treatment of Spastic Paraplegia 56RecruitingNCT06478238Early Phase 11 country
- The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4RecruitingNCT03206190Not applicable1 country
- Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related DisordersRecruitingNCT039812763 countries
- Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular DiseaseActive, not recruitingNCT07478172Not applicable1 country
- Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic ParaplegiaActive, not recruitingNCT06742697Not applicable1 country
- Genetic and Physical Study of Childhood Nerve and Muscle DisordersCompletedNCT015686581 country
- Dental-Oral and Craniofacial Characteristics of Hereditary Spastic Paraplegia: A Preliminary StudyCompletedNCT077992331 country
- A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)TerminatedNCT05394064Phase 1/22 countries
- Enhancement of Quality of Work And LifeActive, not recruitingNCT06573866Not applicable1 country
- Phenotype, Genotype & Biomarkers in ALS and Related DisordersActive, not recruitingNCT023278453 countries
- Phenotype, Genotype and Biomarkers 2Active, not recruitingNCT048754162 countries
- Single and Multiple Ascending Dose Study of MTR-601 in Healthy IndividualsCompletedNCT06117020Phase 11 country
- D-Cycloserine for Serine Palmitoyltransferase InhibitionCompletedNCT07542548Phase 41 country
- Study of Disease Progression in Adults With Inherited Forms of Spastic ParaplegiaTerminatedNCT050088743 countries
- Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5CompletedNCT02314208Phase 21 country
- Assessment of the Psychophysical State During Rehabilitation Treatment With LokomatCompletedNCT057672681 country
- A Pilot Study of Shockwave Therapy in HSPWithdrawnNCT05411627Not applicable
- Identification of Modifying Factors in Hereditary Spastic ParaplegiaCompletedNCT053730821 country
- Imaging Biomarkers in Spastic Paraplegia Type 5CompletedNCT051744031 country
- Effect of Dalfampridine in Patients With Hereditary Spastic ParaplegiaCompletedNCT05613114Not applicable1 country
- Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11)CompletedNCT049126091 country
- Improving Gait Adaptability in Hereditary Spastic ParaplegiaCompletedNCT04180098Not applicable1 country
- Testing Miglustat Administration in Subjects With Spastic Paraplegia 11CompletedNCT04768166Phase 21 country
- Spinal Cord Stimulation Therapy for Hereditary Spastic Paraplegias PatientsStatus unknownNCT05196178Not applicable1 country
- SNAP: Measurement of the Subjective Perception of the Symptom in Hereditary Spastic Paraparesis (HSP)CompletedNCT04256681Not applicable1 country
- PCSK9 Inhibitor Treatment for Patients With SPG5Status unknownNCT04101643Phase 1/21 country
- Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and AdrenomyeloneuropathyCompletedNCT03627416Not applicable1 country
- Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31TerminatedNCT028594281 country
- Studying Cognition in SPG4CompletedNCT031040881 country
- A Patient Centric Motor Neuron Disease Activities of Daily Living ScaleCompletedNCT02852278
- Physiotherapy in Hereditary Spastic ParaplegiaCompletedNCT03961906Phase 21 country
- Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic ParaplegiaCompletedNCT02604186Phase 2/31 country
- Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT006777682 countries