An observational study in Metabolomics, Critical Care and Critical Illness, sponsored by Technical University of Munich. Recruiting at 3 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-03.
Sponsored by Technical University of Munich · Observational
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.
Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.
133 studies on the registry are indexed under Polyneuropathies; 33 are open to participants now.
This study's planned enrollment of 20 is below the median of 100 across 53 observational studies indexed under Polyneuropathies.
Browse Polyneuropathies studies →Technical University of Munich is the lead sponsor of 320 studies on the registry; 58 are open to participants now.
Compared within Polyneuropathies, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Critical Illness. The counts are of registry records indexed under each term, refreshed daily. How we classify →
mechanically ventilated postoperative high-risk patients who are admitted to intensive care
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Postoperative high-risk patients who have been admitted to intensive care after surgery
Elective operative patients where control blood samples and muscle ultrasound will be measured.
Metabolomics
Blood Metabolome will be isolated from blood samples. All samples will be screened for influence of Intensive Care Unit Acquired Weakness (ICUAW) using mass spectrometry.
Time frame: a median of 14 days
Muscle histology
Immunohistochemistry will be done in muscle samples. All samples will be screened for influence of Intensive Care Unit Acquired Weakness (ICUAW) and correlation with blood metabolome changes.
Time frame: a median of 14 days
Phosphoproteomics
Phosphoproteomics will be done in muscle samples using mass spectrometry. All samples will be screened for influence of Intensive Care Unit Acquired Weakness (ICUAW) and correlation with blood metabolome changes.
Time frame: a median of 14 days
Identify possible predictors of muscle wasting in the blood metabolome preoperatively
Among the blood metabolome that will be measured, identify metabolites or combinations of metabolites whose high or low concentration(s) preoperatively associate(s) with the amount of muscle loss. These metabolites are candidate biomarkers that could be used to identify individuals at risk of large muscle wasting and may give further insights into the mechanisms of muscle wasting.
Time frame: a median of 14 days
Identify possible predictors of muscle wasting in the blood metabolome at ICU admission
Among the blood metabolome that will be measured, identify metabolites or combinations of metabolites whose high or low concentration(s) at ICU admission associate(s) with the amount of muscle loss. These metabolites are candidate biomarkers that could be used to identify individuals at risk of large muscle wasting and may give further insights into the mechanisms of muscle wasting.
Time frame: a median of 14 days
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Plan to share: Undecided
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