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Alnylam Pharmaceuticals clinical trials
The registry lists 84 studies whose lead sponsor is Alnylam Pharmaceuticals. 19 are recruiting or about to start. Per ClinicalTrials.gov, last updated Oct 21, 2026.
Keep track of what changes. Save the Alnylam Pharmaceuticals studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesRegistry sponsor names on this page
Each name exactly as ClinicalTrials.gov lists it, and how it relates to Alnylam Pharmaceuticals.
- Alnylam Pharmaceuticals84 studiesSame company
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Focus areas
Conditions Alnylam Pharmaceuticals leads ten or more studies in, by study count. A broader condition is left out when almost all its studies are already in a narrower one listed here.
Studies
Recruiting first, then most recently updated. Showing 50 of 84. Browse all 84 →
- A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyEnrolling by invitationNCT06679946Phase 3
- A Study to Evaluate ALN-6222 in Participants With ObesityRecruitingNCT07624071Phase 1
- A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOADRecruitingNCT05231785Phase 1
- A Study to Evaluate ALN-4285 in Adult Healthy VolunteersRecruitingNCT07295717Phase 1
- TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With CardiomyopathyRecruitingNCT07052903Phase 3
- A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes MellitusRecruitingNCT07465224Phase 2
- A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's DiseaseRecruitingNCT06585449Phase 1
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular DiseaseRecruitingNCT07181109Phase 3
- ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)RecruitingNCT04561518
- A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)RecruitingNCT07636811Phase 2
- A Study to Evaluate ALN-2232 in Participants With ObesityRecruitingNCT07463846Phase 1/2
- DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World SettingRecruitingNCT07358078
- Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance ProgramRecruitingNCT05040373
- A Study to Evaluate ALN-5288 in Patients With Alzheimer's DiseaseRecruitingNCT07214727Phase 1
- A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With ZilebesiranRecruitingNCT07553442Phase 2
- TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyRecruitingNCT07223203Phase 3
- ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)RecruitingNCT04883905
- HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMBRecruitingNCT07575308Phase 2
- A Study to Evaluate ALN-BCAT in Patients With Hepatocellular CarcinomaRecruitingNCT06600321Phase 1
- A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid AngiopathyActive, not recruitingNCT06393712Phase 2
- A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DMActive, not recruitingNCT06845202Phase 1/2
- A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)Active, not recruitingNCT06659640Phase 1/2
- Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With PolyneuropathyActive, not recruitingNCT06360289
- A Study to Evaluate ALN-4915 in Adult Healthy VolunteersActive, not recruitingNCT07535606Phase 1
- BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)Active, not recruitingNCT04982393
- A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate HypertensionCompletedNCT06423352Phase 1/2
- APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)CompletedNCT03997383Phase 3
- Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)CompletedNCT06272487Phase 2
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy SubjectsCompletedNCT05661916Phase 1
- HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyActive, not recruitingNCT04153149Phase 3
- HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)CompletedNCT03759379Phase 3
- A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate HypertensionCompletedNCT04936035Phase 2
- Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)CompletedNCT05103332Phase 2
- A Study to Evaluate ALN-AGT01 RVR in Adult Healthy VolunteersCompletedNCT06675565Phase 1
- A Study to Evaluate Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1CompletedNCT04152200Phase 3
- A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DMTerminatedNCT05761301Phase 1/2
- A Study of Lumasiran in Infants and Young Children With Primary Hyperoxaluria Type 1CompletedNCT03905694Phase 3
- A Study to Evaluate Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1CompletedNCT03681184Phase 3
- A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)TerminatedNCT03841448Phase 2
- A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate LevelsTerminatedNCT05161936Phase 2
- Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)Approved for marketingNCT02939820
- Expanded Access Protocol of Givosiran for Patients With Acute Hepatic PorphyriaApproved for marketingNCT04056481
- A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)TerminatedNCT04565717Phase 1
- An Extension Study of an Investigational Drug, Lumasiran (ALN-GO1), in Participants With Primary Hyperoxaluria Type 1CompletedNCT03350451Phase 2
- APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated AmyloidosisCompletedNCT01960348Phase 3
- ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP)CompletedNCT03338816Phase 3
- Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver TransplantCompletedNCT03862807Phase 3
- Safety and Tolerability of Patisiran (ALN-TTR02) in Transthyretin (TTR) AmyloidosisCompletedNCT01617967Phase 2
- The Study of ALN-TTR02 (Patisiran) for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Who Have Already Been Treated With ALN-TTR02 (Patisiran)CompletedNCT01961921Phase 2
- A Study to Evaluate ALN-XDH in Healthy Subjects and Patients With GoutTerminatedNCT05256810Phase 1/2