Muscle Cramp clinical trials
The registry lists 65 studies for Muscle Cramp across more than 10 countries. 9 are recruiting or about to start. 34 of them are mainly about Muscle Cramp (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
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Who runs them
Chinese University of Hong Kong (2) · Flex Pharma, Inc. (2) · Mayo Clinic (2) · University of Michigan (2) · Purdue University (2) · National Institute of Mental Health (NIMH) (2) · University of Texas Southwestern Medical Center (2) · Yonsei University (2)
What is being tested here
Drugs under test in Muscle Cramp studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
Who these studies take
Of the 3 Muscle Cramp studies recruiting now, 2 (67%) set no upper age limit and 1 (33%) stop at 75 or younger. 1 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (67%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (33%) | 1 (33%) |
| 18 | 2 (67%) | 2 (67%) |
| 30 | 2 (67%) | 2 (67%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 3 (100%) | 3 (100%) |
| 75 | 3 (100%) | 3 (100%) |
| 85 | 2 (67%) | 2 (67%) |
Across all 65 studies, recruiting or not: 37% stop at 75 or younger and 31% at 65; 15% take children; 12% are for women only and 0% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Muscle Cramp studies take
Of 20 interventional studies with no phase under Muscle Cramp, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 8 mo3–11 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 65. Browse all 65 → or search them.
- The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg CrampsRecruitingNCT07651514Not applicable1 country
- Comparative Study Between Leg Massage and Vibration on Cramps and Comfort for Patients Undergoing HemodialysisNot yet recruitingNCT07777354Not applicable
- Kinesiotape Versus Compression Stockings on Pregnant Leg Cramps and Sleep QualityNot yet recruitingNCT07683494Not applicable1 country
- Efficacy of CL25216 on Hormonal Balance and Menstrual Health in Women With Primary Dysmenorrhea.Not yet recruitingNCT07529561Not applicable1 country
- Weighted Blanket in PregnancyNot yet recruitingNCT07309016Not applicable1 country
- Prevalence and Severity of Cramps in Chronic Kidney Disease PatientsNot yet recruitingNCT067370941 country
- The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron HyperexcitabilityRecruitingNCT05908214Not applicable1 country
- Effectiveness and Safety of Shaoyao Gancao Decoction With Addition on the Sleep-related Leg CrampsNot yet recruitingNCT05980637Phase 2/31 country
- Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With CirrhosisRecruitingNCT02423395Phase 31 country
- Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle DiseaseActive, not recruitingNCT036609692 countries
- The Effect of Home-Based Walking on Symptoms and Health Profile of Hemodialysis PatientsActive, not recruitingNCT07272070Not applicable1 country
- Compression Stockings for Prevention of Hemodialysis Muscle CrampsCompletedNCT07293182Not applicable1 country
- Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium LevelsCompletedNCT07565779Not applicable1 country
- Outcomes of a Higher vs. Lower Hemodialysate Magnesium Concentration (Dial-Mag)Active, not recruitingNCT04079582Not applicable1 country
- Effects of Telerehabilitation-based Motor Imagery and Exercise Combination in Individuals With Postural Kyphosis: A Randomized Controlled TrialCompletedNCT07122791Not applicable1 country
- The Relationship of the Joint Blockage and Muscle SpasmCompletedNCT07264530Not applicable1 country
- Stretching Exercises for Dialysis Patients to Reduce Muscle CrampsCompletedNCT07262879Not applicable1 country
- TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle CrampsCompletedNCT04998305Phase 1/21 country
- Ultrasonic Perfusion Estimation in Calf MuscleCompletedNCT047553351 country
- Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25CompletedNCT06227676Phase 2/31 country
- Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With CirrhosisCompletedNCT05724485Phase 41 country
- The RELAX Trial: Nonpharmaceutical Intervention for Nocturnal Muscle CrampsCompletedNCT05457322Not applicable1 country
- Treatment of Muscle Cramps in Patients With Liver CirrhosisCompletedNCT01495403Early Phase 11 country
- The Effect of Grounding During PregnancyStatus unknownNCT05557188Not applicable1 country
- 7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle EventsTerminatedNCT04507373Phase 41 country
- The Effect of Aromatherapy Massage Applied to Hemodialysis Patients With Muscle CrampCompletedNCT04874857Not applicable1 country
- 7 Tesla MRI Study in Patients With Statin Related Muscle ComplaintsCompletedNCT04575090Not applicable1 country
- Ropinirole for the Treatment of Muscle Cramps in Patients With CirrhosisCompletedNCT03176966Phase 41 country
- Effectiveness of Intradialytic Exercise on Reduction in Fatigue and Muscle CrampsCompletedNCT05382468Not applicable1 country
- Effect of Kinesio Tape Application and Stretching Exercises on Calf Cramps During PregnancyStatus unknownNCT05281289Not applicable1 country
- Tolperisone in Acute Muscle Spasm of the BackCompletedNCT03802565Phase 21 country
- Non-Pharmaceutical Intervention for Cirrhotic Cramps Reduction: The NICCles TrialCompletedNCT04650295Not applicable1 country
- The Effect of the Massage on Cramp Frequency, Cramp Severity, and Sleep QualityCompletedNCT04990661Not applicable1 country
- Intradialytic Stretching Exercises on Prevention and Reduction of Leg Muscle CrampsCompletedNCT04901832Not applicable1 country
- Prospective Cohort Study of Adolescents Living With HIV and Their Caregivers Attending a Psychosocial Programme in BotswanaCompletedNCT035715551 country
- Prevention of Leg Cramps Using Compression Stockings or Magnesium Supplements in the Age Group of 50 to 84Status unknownNCT04694417Not applicable
- Hot and Cold Compress in HemodialysisCompletedNCT04681521Not applicable1 country
- PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright SyndromeCompletedNCT02743377Phase 1/21 country
- Evaluate the Efficacy of Herbal Medicine (Shaoyao Gancao Decoction Jiawei) in Sleep-related Leg CrampsCompletedNCT04500730Not applicable1 country
- A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver CirrhosisCompletedNCT01271660Phase 31 country
- Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)TerminatedNCT03030391Phase 11 country
- Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal StenosisCompletedNCT02444351Not applicable1 country
- A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.TerminatedNCT03196375Phase 21 country
- A Study to Assess the Safety and Effectiveness of FLX-787 in Subjects With Charcot-Marie-Tooth Disease Experiencing Muscle Cramps.TerminatedNCT03254199Phase 21 country
- Calcium Metabolism in Mexican American AdolescentsCompletedNCT01277185Not applicable1 country
- The Summer Camp Study 2: Blood Glucose Control With a Bi-Hormonal Endocrine PancreasCompletedNCT02105324Not applicable1 country
- The Summer Camp Study: Blood Glucose Control With a Bi-Hormonal Bionic Endocrine PancreasCompletedNCT01833988Not applicable1 country
- Mexiletine for the Treatment of Muscle Cramps in ALSCompletedNCT01811355Phase 41 country
- Botulinum Toxin for Cramps in Diabetic NeuropathyCompletedNCT03238898Phase 2
- Diagnostic Evaluation of Patients With Neuromuscular DiseaseCompletedNCT000154701 country